Referencia número: HY-N3377

Liriodendrin

Name: Liriodendrin
Brand: MedChemExpress
SKU: HY-N3377
Price: 435.00 USD
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Liriodendrin is an orally effective lignan compound with anti-inflammatory, antioxidant, and anti-platelet aggregation activities. Liriodendrin is isolated and extracted from Sargentodoxae caulis and Linaria vulgaris. Liriodendrin regulates the expression of genes related to inflammation and cellular metabolism by inhibiting the NF-κB, PI3K/Akt, and TLR4 signaling pathways, or by activating the PI3K-DDX18 pathway. Liriodendrin increases the expression of HSF1 and HSP27 without cytotoxicity. Liriodendrin is used in studies on ulcerative colitis, myocardial ischemia-reperfusion injury, sepsis-induced acute lung injury, and chronic endometritis.

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Pureza : 99.02%
No. CAS: 573-44-4
Fòrmula: C₃₄H₄₆O₁₈
Peso molecular:742.72

Almacenamiento:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Liriodendrin Chemical Structure

No. CAS: 573-44-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]^[2]

HSF1

TLR4

Ver todos los productos específicos de isoformas HSP :

Ver todos los productos específicos de isoformas NF-κB :

Ver todos los productos específicos de isoformas PI3K :

Ver todos los productos específicos de isoformas Akt :

Ver todos los productos específicos de isoformas Toll-like Receptor (TLR) :

Ver todos los productos específicos de isoformas Endogenous Metabolite :

Cellular Effect

Cell Line	Type	Value	Description	References
L132	IC₅₀	>5 μM	Cytotoxicity against human L132 cells assessed as reduction in cell viability by MTT assay. Cytotoxicity against human L132 cells assessed as reduction in cell viability by MTT assay.	39134870

In Vitro

Innate ImmunityCytokines & ChemokinesCell Cycle RegulationMitochondrial FunctionOxidative StressOthers

Innate Immunity

Cytokines & Chemokines

Liriodendrin (20-100 μM; pretreatment for 2 h) inhibits LPS (HY-D1056)-stimulated production of pro-inflammatory cytokines and suppresses NF-κB activation in RAW 264.7 macrophages, but does not affect Akt phosphorylation^[5].

Cell Cycle Regulation

Liriodendrin (0.45-2.25 mM; 24 h) dose-dependently promotes cell proliferation, promotes cell cycle transition, and increases milk protein synthesis in bovine mammary epithelial cells (MECs)^[6].

Innate Immunity

Mitochondrial Function

Liriodendrin (20-100 μM; 24 h) protects mitochondrial morphology, inhibits apoptosis, and suppresses NF-κB signaling pathway activation in rat cardiomyocytes H9C2 under hypoxia/reoxygenation conditions^[3].

Innate Immunity

Oxidative Stress

Liriodendrin (50 μM) inhibits pro-inflammatory cytokine secretion, reduces reactive oxygen species (ROS) production, and suppresses NF-κB (p65) phosphorylation in mouse macrophage RAW 264.7 cells^[4].

Others

Liriodendrin (3 μM; 12 h) induces HSF1 and HSP27 protein expression in L132 human lung fibroblasts^[1].
Liriodendrin shows no cytotoxicity in L132 human lung fibroblasts at concentrations up to 5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[5]

Cell Line:

RAW 264.7
Concentration:

20 μM, 50 μM, 100 μM
Incubation Time:

2 h pre-treatment prior to LPS exposure for 4 h
Result:

Decreased the mRNA levels of TNF-α, IL-6, and IL-1β, and had no significant effect on ERβ mRNA expression.

Western Blot Analysis^[5]

Cell Line:

RAW 264.7
Concentration:

20 μM, 50 μM, 100 μM
Incubation Time:

2 h pre-treatment prior to LPS exposure for 4 h
Result:

Significantly reduced the phosphorylation of NF-κB and IκBα.
Had no effect on the phosphorylation of Akt.

Cell Cycle Analysis^[6]

Cell Line:

Primary bovine mammary epithelial cells (MECs)
Concentration:

0.45 mM, 0.9 mM, 1.35 mM, 1.8 mM, 2.25 mM
Incubation Time:

24 h
Result:

Reduced the proportion of cells in the G1 phase and increased the proportion of cells in the S and G2/M phases.

Cell Proliferation Assay^[6]

Cell Line:

Primary bovine mammary epithelial cells (MECs)
Concentration:

0.45 mM, 0.9 mM, 1.35 mM, 1.8 mM, 2.25 mM
Incubation Time:

24 h
Result:

Increased cell number and promoted cell proliferation in a dose-dependent manner, peaking at 1.35 mM.

Western Blot Analysis^[3]

Cell Line:

H9C2 cardiomyocytes
Concentration:

20, 50, 100 μM
Incubation Time:

24 h
Result:

Decreased protein expression levels of p-NF-κB and p-IκBα at all concentrations.
At 100 μM, decreased Bax protein expression levels and increased Bcl-2 protein expression.

ELISA Assay^[4]

Cell Line:

RAW 264.7
Concentration:

50 μM
Incubation Time:

pre-treated for 6 h before LPS stimulation, co-treated with LPS for 18 h
Result:

Reduced the secretion of TNF-α, IL-1β, MCP-1, and IL-6.

Western Blot Analysis^[1]

Cell Line:

L132 human embryonic lung fibroblast cells
Concentration:

3 μM
Incubation Time:

12 h
Result:

Induced an increase in the protein expression of HSF1 and HSP27

Real Time qPCR^[3]

Cell Line:

Rat H9C2 cardiomyocytes
Concentration:

100 μM
Incubation Time:

24 h
Result:

Decreased the mRNA transcriptional activities of Bax and Caspase-3, and increased the Bcl-2/Bax ratio.

In Vivo

Oxidative StressCytokines & ChemokinesInnate ImmunityApoptosisRegulation of Cardiac Pump FunctionOthers

Oxidative Stress

Cytokines & Chemokines

Innate Immunity

Liriodendrin (100 mg/kg; p.o.; once daily; 10 days) ameliorates the disease activity index, increases antioxidant enzyme activity, and inhibits Akt and NF-κB signaling pathways in a 3% DSS (HY-116282C)-induced ulcerative colitis model in male BALB/c mice^[5].

Apoptosis

Oxidative Stress

Regulation of Cardiac Pump Function

Liriodendrin (100 mg/kg; p.o.; once daily; from 5 days before surgery to 3 days after surgery) ameliorates ventricular remodeling, inhibits inflammatory cytokines, and attenuates cardiomyocyte apoptosis in a male Wistar rat model of myocardial ischemia-reperfusion injury induced by left anterior descending coronary artery ligation^[3].

Innate Immunity

Liriodendrin (20 mg/kg; i.p.; administered at 0 and 6 h after CLP, days 1-5) improves survival, alleviates lung histopathological injury, and inhibits pro-inflammatory mediator production in a cecal ligation and puncture (CLP)-induced acute lung injury model of sepsis in male C57BL/6 mice^[4].
Liriodendrin (50-200 mg/kg; p.o.; once daily; 21 days) alleviates uterine inflammation, modulates gut microbiota, and inhibits the L-arginine/NO metabolic pathway in a chronic endometritis model of female Sprague-Dawley rats^[2].

Others

Liriodendrin (1.45-13.05 mg/kg/d; p.o.; once daily; for 7 days) promotes β-casein and DDX18 expression in mammary tissue and increases the body weight of offspring mice in a maternal ICR mouse model on lactation day 10^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (6-week-old, male, 20 ± 2 g)^[5]
Dosage:

100 mg/kg
Administration:

p.o.; once daily; pretreated 3 days before DSS treatment and continued during the 7-day DSS treatment period
Result:

Decreased the disease activity index (DAI) compared with the DSS group.
Significantly reversed the shortening in colon length induced by DSS.
Attenuated pathological changes induced by DSS treatment and markedly inhibited inflammation scores compared with the DSS group.
Significantly reduced the DSS-induced increase in MPO activity.
Significantly reduced the levels of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β.
Significantly attenuated the decrease in the activities of antioxidant enzymes SOD and GPx induced by DSS treatment and significantly counteracted the DSS-induced elevated malondialdehyde (MDA).
Led to a significant reduction in the phosphorylation of NF-κB and Akt, and blocked the phosphorylation of IκBα in the colon.
Significantly up-regulated the mRNA expression of ERβ in the colon compared to the DSS group.

Animal Model:

ICR (11-week-old lactating mothers)^[6]
Dosage:

1.45 mg/kg/d; 4.35 mg/kg/d; 13.05 mg/kg/d
Administration:

p.o.; once daily; for 7 d
Result:

Produced higher expression of β-casein and DDX18 in mouse mammary gland and greater weight gain of offspring mice at 4.35 mg/kg/d than the normal feeding group and the 1.45 mg/kg/d group.
Showed reduced effects at 13.05 mg/kg/d compared with the 4.35 mg/kg/d group.

Animal Model:

Wistar rats (male, 8 weeks old, 200 g)^[3]
Dosage:

100 mg/kg
Administration:

intragastric; daily; 5 days before surgery to 3 days after surgery
Result:

Decreased I/R-induced elevation of CKMB and cTnT levels.
Reversed I/R-induced elevation of EDV and LVIDd.
Lowered EF, LVIDs, and ESV compared with the I/R group.
Reduced inflammatory cell infiltration and pathological alterations.
Decreased MCP-1 expression and ROS levels.
Increased SOD levels in peripheral blood.
Decreased expression of Bax and cleaved caspase-3.
Increased expression of Bcl-2.
Markedly decreased apoptosis index (AI), though not statistically significant.
Increased Bcl-2 protein expression and decreased Bax and cleaved caspase-3 protein expression.
Decreased expression of p-NF-κB and p-IκBα.

Animal Model:

C57BL/6 mice (male, 6-8 weeks old)^[4]
Dosage:

20 mg/kg
Administration:

i.p.; dose at 0 and 6 h after CLP (mortality study); 20 mg/kg for the 24-h lung injury study
Result:

Improved survival rate to 30%.
Mitigated lung hemorrhage, edema, fibrin deposition, and neutrophil accumulation at 24 h.
Reduced CLP-induced increase in lung MPO activity.
Significantly reduced albumin content in BAL fluids.
Lowered levels of TNF-α, IL-1β, MCP-1, and IL-6 in BAL fluids at 24 h.
Suppressed expression of VEGF and phosphorylation of NF-kB (p65) in septic lungs.

Animal Model:

Sprague-Dawley (Female, 200-220 g, 15% hydroxybenzene mucilage-induced chronic endometritis)^[2]
Dosage:

50 mg/kg ; 100 mg/kg; 200 mg/kg
Administration:

p.o.; once daily; 21 days
Result:

Suppressed CE-induced pathological changes in uterus tissues and decreased the number of inflammatory cells.
Did not adversely affect the tissue morphology or exert toxic effects on the liver and kidney.
Mitigated the CE-induced upregulation of TLR4 and P-p65 protein levels in uterine tissues.
Suppressed the CE-induced upregulation of Tlr4, Tnf-α, Il-1β, and Il-6 mRNA levels and downregulation of Il-10 mRNA levels in the uterus tissues.
Decreased the CE-induced upregulation of the Firmicutes/Bacteroidetes ratio.
Downregulated the abundances of Campilobacterota and Bacteroidetes and downregulated the abundances of Actinobacteria and Candidatus_Saccharibacteria in CE rats.
Mitigated the CE-induced upregulation of Lachnospiraceae_unclassified and Clostridiales_unclassified abundances, and suppressed the CE-induced downregulation of Ruminococcaceae_unclassified and Muribaculaceae_unclassified relative abundances.
Downregulated Arg-2 levels in a dose-dependent manner.
Mitigated the CE-induced downregulation of NO, eNOS, and L-arginine in the uterus tissues.

Related Protocols :

Chemical Information

No. CAS 573-44-4
Appearance Solid
Peso molecular 742.72
Fòrmula C₃₄H₄₆O₁₈
Color White to off-white
SMILES

COC1=C(O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)C(OC)=CC([C@@H]3[C@]4([H])[C@@](CO3)([H])[C@@H](C5=CC(OC)=C(C(OC)=C5)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)OC4)=C1
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Journal Impact Factor

Int J Mol Med

Liriodendrin alleviates myocardial ischemia‑reperfusion injury via partially attenuating apoptosis, inflammation and mitochondria damage in rats. [Abstract]

2025 Apr;55(4):65. PMID: 39981888

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (316 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Nam JW, et al. Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents. Chemistry & biodiversity. 2013 Jul;10(7):1322-7. [Content Brief]

[2]. Cheng F, et al. Liriodendrin exerts protective effects against chronic endometritis in rats by modulating gut microbiota composition and the arginine/nitric oxide metabolic pathway. International immunopharmacology. 2024 Jan 05;126:111235.

[3]. Li B, et al. Liriodendrin alleviates myocardial ischemia‑reperfusion injury via partially attenuating apoptosis, inflammation and mitochondria damage in rats. International journal of molecular medicine. 2025 Apr;55(4):65. [Content Brief]

[4]. Yang L, et al. Protective Role of Liriodendrin in Sepsis-Induced Acute Lung Injury. Inflammation. 2016 Oct;39(5):1805-13.

[5]. Zhang Z, et al. Protective role of liriodendrin in mice with dextran sulphate sodium-induced ulcerative colitis. International immunopharmacology. 2017 Nov;52:203-210.

[6]. Qiu Y, et al. Liriodendrin stimulates proliferation and milk protein synthesis of mammary epithelial cells via the PI3K-DDX18 signaling. In vitro cellular & developmental biology. Animal. 2024 Sep;60(8):949-958.

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Liriodendrin

1 Cited Publications

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Liriodendrin

Publications Citing Use of MedChemExpress (MCE) Liriodendrin

Ver todos los productos específicos de isoformas HSP

Ver todos los productos específicos de isoformas NF-κB

Ver todos los productos específicos de isoformas PI3K

Ver todos los productos específicos de isoformas Akt

Ver todos los productos específicos de isoformas Toll-like Receptor (TLR)

Ver todos los productos específicos de isoformas Endogenous Metabolite