GC - GC vitamin D binding protein Gene

Also Known as DBP; VDB; GRD3; VDBG; VDBP; GcMAF; DBP/GC; Gc-MAF; DBP-maf; HEL-S-51

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2638

About GC

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:71,741,693-71,805,520 (from NCBI)

This gene has 8 transcripts (splice variants), 140 orthologues and 3 paralogues. Restricted expression toward liver (RPKM 1264.0).

Summary

The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

GC Products (3)

mRNA	Protein	Name
NM_000583.4	NP_000574.2	vitamin D-binding protein isoform 1 precursor
NM_001204306.1	NP_001191235.1	vitamin D-binding protein isoform 1 precursor
NM_001204307.1	NP_001191236.1	vitamin D-binding protein isoform 3 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IPI IPI: Inferred from physical interaction	12119014	GOA
enables calcidiol binding	IDA IDA: Inferred from direct assay	11799400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GC Protein Structure

Serum_albumin

VitD-bind_III

0
100
200
300
400
474 a.a.

Protein Preferred Names	Protein Names
vitamin D-binding protein	epididymis secretory protein Li 51

Recombinant GC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71068	Vitamin D-binding protein/GC Protein, Human (HEK293, His)	P02774-1 (L17-L474)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71736	Vitamin D-binding protein/GC Protein, Human (P.pastoris, His-SUMOstar)	P02774-1 (R19-L474)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72202	Vitamin D-binding protein/GC Protein, Human (His)	P02774-1 (R19-L474)	≥ 90%, as determined by reducing SDS-PAGE.

GC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80930	Vitamin D Binding Protein Antibody (YA009)	WB, ICC/IF	Human, Mouse, Rat
HY-P80930A	Vitamin D Binding Protein Antibody (YA009)(PBS only)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Rickets	Vitamin D Deficiency Vitamin D Active Rickets Hypovitaminosis D Nutritional Rickets Vitamin D Deficiency Disease Vitamin-D Deficiency Rickets Vitamin D-Dependent Rickets Avitaminosis D Infantile Osteomalacia Juvenile Osteomalacia
Blastomycosis	Gilchrist'S Disease North American Blastomycosis Blastomyces Dermatitidis Infection Blastomycotic Infection Infection By Blastomyces Dermatitidis Gilchrist Disease Chicago Disease Chicago Disease Or Disorder Blastomycosis, Unspecified Blastomyces Infection
Hepatic Encephalopathy	Encephalopathy, Hepatic Portal-Systemic Encephalopathy Hepatoencephalopathy He - [Hepatic Encephalopathy] Hepatic Encephalopathy Nos Hepatic Encephalopathy, Stage Unspecified Hepatic Coma Hepatocerebral Encephalopathy Hepatocerebral Intoxication
Osteoporosis, Juvenile	Idiopathic Juvenile Osteoporosis Idiopathic Osteoporosis Juvenile Osteoporosis Ijo
Osteomalacia	Adult Rickets
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Hyperparathyroidism	Hyperparathyroidism And Other Disorders Of Parathyroid Gland Parathyroid Hyperfunction Hpth - [Hyperparathyroidism] Parathyroid Gland Hyperfunction Parathyroid Glandular Hyperfunction
Cystinosis	Cystine Storage Disease Cystine Diathesis Cystine Disease Cystinoses Protein Defect Of Cystin Transport Cystin Transport, Protein Defect Of Nephropathic Cystinosis Protein Defect Of Cystine Transport
Pulmonary Tuberculosis	Tuberculosis, Pulmonary PTB Tuberculosis Pulmonary
Anteroseptal Myocardial Infarction
Donnai-Barrow Syndrome	Faciooculoacousticorenal Syndrome Dbs/Foar Syndrome Foar Syndrome Diaphragmatic Hernia-Exomphalos-Hypertelorism Syndrome Facio-Oculo-Acoustico-Renal Syndrome Diaphragmatic Hernia, Exomphalos, Absent Corpus Callosum, Hypertelorism, Myopia, Sensorineural Deafness, And Proteinuria Diaphragmatic Hernia-Hypertelorism-Myopia-Deafness Syndrome Holmes-Schepens Syndrome Syndrome Of Ocular And Facial Anomalies, Telecanthus And Deafness DBS Diaphragmatic Hernia Exomphalos Absent Corpus Callosum Hypertelorism Myopia Sensorineural Deafness And Proteinuria Diaphragmatic Hernia-Exomphalos-Corpus Callosum Agenesis Diaphragmatic Hernia-Hypertelorism-Myopia-Hearing Loss Syndrome Syndrome Of Ocular And Facial Anomalies, Telecanthus And Hearing Loss Donnai Barrow Syndrome
Hypervitaminosis D	Vitamin D Hyperalimentation
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Parathyroid Gland Disease	Parathyroid Diseases Disease Of Parathyroid Glands Parathyroid Disease
Vitamin D-Dependent Rickets	Vddr
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Diabetes Mellitus	Diabetes
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Mineral Metabolism Disease	Mineral Metabolism Disorder Disorder Of Mineral Metabolism
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Scoliosis
Analbuminemia	ANALBA Congenital Analbuminemia Hypoalbuminemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0561	Spironolactone		99.81%	Yes
HY-13693	Mometasone furoate	Agonist	99.90%	Yes
HY-108741	Plecanatide	Agonist	99.93%	Unkown
HY-17569	Difluprednate	Inhibitor	99.63%	Yes
HY-108741A	Plecanatide acetate	Agonist	99.70%	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-141642	Triheptadecanoin		98.0%	Phase 4
HY-109110	Avasopasem manganese		96.07%	Phase 3
HY-14823	Sobetirome	Agonist	99.91%	Phase 2
HY-13336	Imisopasem manganese		96.33%	Phase 2
HY-P0118	Disitertide		98.03%	Phase 2
HY-14181A	Cinaciguat hydrochloride	Activator	98.90%	Phase 2
HY-132829	Rucosopasem manganese		/	Phase 2
HY-10498A	Lexibulin dihydrochloride		/	Phase 2
HY-145381	11β-HSD1-IN-6	Inhibitor	/	Phase 2
HY-P3499	Dolcanatide	Agonist	99.20%	Phase 1
HY-12946A	BI 653048 phosphate	Inhibitor	/	Phase 1

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99693	Lenvervimab	Inhibitor	≥99%	Phase 3
HY-P99013	Codrituzumab	Inhibitor	99.07%	Phase 2
HY-P99020	Fresolimumab	Inhibitor	99.51%	Phase 2
HY-P991571	GC1118	Inhibitor	99.22%	Phase 2
HY-P991582	BI-1607	Antagonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (82)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108314A	GC7 Sulfate	Inhibitor	98.0%	Unkown
HY-D1020	7-Aminoactinomycin D	Inhibitor	≥99.0%	Unkown
HY-136684	BrBzGCp2	Inhibitor	99.00%	Unkown
HY-111798	Heme Oxygenase-1-IN-1	Inhibitor	99.13%	Unkown
HY-141513	NH-3	Antagonist	99.41%	Unkown
HY-100721	GC376 sodium	Inhibitor	99.53%	Unkown
HY-W127512	5β-Cholanic acid		99.87%	Unkown
HY-111798A	Heme Oxygenase-1-IN-1 hydrochloride	Inhibitor	99.03%	Unkown
HY-13963	ZCL278	Inhibitor	98.49%	Unkown
HY-111208	CCT129957	Inhibitor	99.16%	Unkown
HY-P0118B	Disitertide diammonium		99.00%	Unkown
HY-W040129	Chromomycin A3		99.66%	Unkown
HY-108628	SU16f	Inhibitor	99.36%	Unkown
HY-D1191	SYBR green I chloride		98.09%	Unkown
HY-10498	Lexibulin		99.10%	Unkown
HY-132184	5,6-Epoxyeicosatrienoic acid	Inhibitor	99.9%	Unkown
HY-W089645	2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide		98.79%	Unkown
HY-W004290	Methyl heptadecanoate		99.69%	Unkown
HY-I0450	Anticancer agent 265		99.64%	Unkown
HY-W004290S	Methyl heptadecanoate-d33		99.52%	Unkown
HY-152038	SPEN-IN-1	Inhibitor	97.25%	Unkown
HY-130189	S-Phenylmercapturic acid		99.38%	Unkown
HY-113422	Tetrahydrocorticosterone		99.90%	Unkown
HY-149453	MCUF-651	Modulator	99.85%	Unkown
HY-131389	Cholesteryl heptadecanoate		98.0%	Unkown
HY-DY1099	7-Aminoactinomycin D (solution)	Inhibitor	/	Unkown
HY-12946	BI 653048	Inhibitor	99.84%	Unkown
HY-114043	NCGC00092410	Inhibitor	98.10%	Unkown
HY-160178	Glucocorticoid receptor agonist-3 Ala-Ala-Mal		99.70%	Unkown
HY-155789	C17 Globotriaosylceramide (d18:1/17:0)		≥99.0%	Unkown
HY-108314	GC-7	Inhibitor	/	Unkown
HY-151482	SARS-CoV-2 Mpro-IN-2	Inhibitor	98.96%	Unkown
HY-107547	BPIPP	Inhibitor	98.3%	Unkown
HY-113422S	Tetrahydrocorticosterone-d5		97.45%	Unkown
HY-114577	Palifosfamide tromethamine	Chemical	98.74%	Unkown
HY-B0561S4	Spironolactone-d6-1		99.26%	Unkown
HY-N6651	Isocryptotanshinone		≥98.0%	Unkown
HY-P0118A	Disitertide TFA		/	Unkown
HY-123023	12(S)-HETE-d8	Inducer	98.00%	Unkown
HY-N10220	Paraherquamide E		95.0%	Unkown
HY-101282	Glutaminyl Cyclase Inhibitor 3	Inhibitor	/	Unkown
HY-108353S	Isoprenaline-d7 acetate		/	Unkown
HY-111442	GC 14	Antagonist	/	Unkown
HY-113422S1	Tetrahydrocorticosterone-d3		/	Unkown
HY-113422S2	Tetrahydrocorticosterone-d3-1		/	Unkown
HY-118274	ADDA		/	Unkown
HY-130229	(±)5,6-DHET lactone		/	Unkown
HY-13963S	ZCL278-13C		/	Unkown
HY-141717	α-cis-Bergamotene		/	Unkown
HY-146398	AMPK activator 6	Activator	/	Unkown
HY-14823G	Sobetirome (GMP)	Agonist	/	Unkown
HY-148392	Neu5Gcα(2-6) N-Glycan-Asn		/	Unkown
HY-149774	GC-78-HCl		/	Unkown
HY-156020	Glucocerebrosidase-IN-2	Inhibitor	/	Unkown
HY-157001	7-Deaza-dGTP tetralithium		/	Unkown
HY-160180	Glucocorticoid receptor agonist-4 Ala-Ala-Mal		/	Unkown
HY-162293	CDK8-IN-14	Inhibitor	/	Unkown
HY-166965	Neu5Gc(α2,6)N-Acetylgalactosamine		/	Unkown
HY-17569S2	Difluprednate-d3-1	Inhibitor	/	Unkown
HY-178738	GC-072	Inhibitor	/	Unkown
HY-179535	Axl-IN-21	Inhibitor	/	Unkown
HY-N15629	Melicopicine		/	Unkown
HY-N15820	C18:0 GM1(Neu5Gc) Ceramide (d18:1/18:0)		/	Unkown
HY-N15822	C18:0 GM3(Neu5Gc) Ceramide (d18:1/18:0)		/	Unkown
HY-N15823	C18:0 GM2(Neu5Gc) Ceramide (d18:1/18:0)		/	Unkown
HY-N18337	Salidroside 3-O-glucopyranoside		/	Unkown
HY-P10786	LinTT1 peptide	Inhibitor	/	Unkown
HY-P1911	CEF27, Epstein-Barr Virus BRLF-1 lytic (148-156)		/	Unkown
HY-RS05316	GC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W127357	Tripelargonin		/	Unkown
HY-W127496	Methyl 13-methyltetradecanoate		/	Unkown
HY-W130478S	1-Phenylhexane-d5		/	Unkown
HY-120410	DL-4662		/	Unkown
HY-154171	Deoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one		99.87%	Unkown
HY-165420	GC-IN-2	Inhibitor	/	Unkown
HY-183956	GC813	Inhibitor	/	Unkown
HY-N10626	Neu5Gcα(2-6) N-Glycan		/	Unkown
HY-RS16765	Gc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20039	Il2rg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20738	Gba1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23205	Gc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W099771	4-Propylanisole		99.05%	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991302	KL-A289	Inhibitor	/	Unkown
HY-P990844	Anti-GC1q R/C1QBP Antibody (60.11)	Inhibitor	/	Unkown
HY-P991482	ADI-42898	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GC	MGD	MGI:95669
Felis catus	GC	VGNC	VGNC:62485
Canis familiaris	GC	VGNC	VGNC:41136
Bos taurus	GC	VGNC	VGNC:29277
Macaca mulatta	GC	VGNC	VGNC:72897
Rattus norvegicus	GC	RGD	RGD:2667
Others	GC	NCBI