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カンプトテシン

(別名: Camptothecin; CPT)
70 Cited Publications
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Based on 70 publication(s) in Google Scholar

Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.

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  • 純度: 99.77%
  • CAS 番号: 7689-03-4
  • 分子式: C20H16N2O4
  • 分子量:348.35
  • 保管条件:

    4°C, protect from light

    * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

  • Camptothecin Chemical Structure
    Camptothecin 構造式
  • Experimental Validation Results for Camptothecin
  • Experimental Validation Results for Camptothecin
  • Experimental Validation Results for Camptothecin
  • Experimental Validation Results for Camptothecin
CAS 番号: 7689-03-4
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  • Camptothecin Chemical Structure
    Camptothecin Chemical Structure
    1/16
  • 1/16

    Camptothecin purchased from MedChemExpress. Usage Cited in: Arch Cancer Res. 2023 Jan 30.

    Customer Validation
     Camptothecin (CPT; 10-5 -10-10 M; 72 h) demonstrates a strong antitumor activity and an inhibitory of proliferation (IC50 = 25.36 nM) in U937 cells.

  • 1/16

    Camptothecin purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2020 Nov;27(11):3162-3176. [Abstract]

    Customer Validation
     293T cells transfected with Flag-TopBP1 and GFP-tagged RBMX and its domain (RRM, RBM1CTR, and C-RBD) are treated with 100 nM CPT for 24 h and subjected to immunoprecipitation with Flag-beads. Immunoprecipitates are immunoblotted with Flag and GFP antibodies, respectively.

  • 1/16

    Camptothecin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761. [Abstract]

    Customer Validation
     Genotoxic stress-induced β-catenin signaling is activated via a TCF- or FOXO-independent mechanism. Representative images of the subcellular localization of β-catenin in the indicated cells treated with CPT (10 μM, 1 h), IR (10 Gy), and CDDP (10 μM, 1 h), as analyzed by immunofluorescence staining.

  • 1/16

    Camptothecin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Oct 8;9(1):4139. [Abstract]

    Customer Validation
     One hour after treated with UV or 2 h after treated with MMS, Camptothecin (CPT) (10 μM), or Doxorubicin (DOX; 0.5 μM), HEK293T cells expressing HA-SUMO2 and His-RhoB are subjected to sumoylation assay to detect the SUMO2 conjugation of RhoB.

  • Camptothecin