Neral

Neral (6.6-66 μM; 24 h) promotes J774A.1 cell proliferation at the concentration of 66 μM^[1].
Neral (0-100 μM; 30 min preincubation followed by 6 h LPS stimulation) dose-dependently inhibits LPS-induced secretion of TNF-α and IL-6, suppresses the expression of iNOS, COX-2 and NLRP-3, and significantly reduces the expression of pro-IL-1β^[1] in J774A.1 mouse macrophages.
Neral (6.6-66 μM; 30 min preincubation, followed by 5.5 h LPS stimulation and 30 min ATP stimulation) inhibits the activation of NLRP-3 inflammasome in J774A.1 mouse macrophages, and reduces the production of caspase-1 p10 and the secretion of IL-1β^[1].
Neral (66 μM; 30 min preincubation followed by 10-60 min LPS stimulation) inhibits LPS-induced phosphorylation of p38 and IκB in J774A.1 murine macrophages, slightly reduces the level of phosphorylated ERK1/2, and exerts no effect on phosphorylated JNK1/3^[1].
Neral (6.6-66 μM; 30 min preincubation with neral and CM-DCFH-DA, followed by 0-60 min LPS stimulation) inhibits LPS-induced intracellular ROS production in J774A.1 mouse macrophages^[1].
Neral (9.9 μM, micelle-encapsulated) inhibits the proliferation of 4T1 breast cancer cells, with an IC₅₀ of 9.9 μM^[2].
Neral (20 mg/L; 72 h, co-applied with 0.35 mg/L fenoxaprop-p-ethyl) significantly promotes root elongation of 'Mianyou 838' rice, resulting in a root length 1.8 times that of plants treated with fenoxaprop-p-ethyl (HY-B2013) alone^[3].
Neral (20 mg/L; 24 h) induces 895 uniquely up-regulated genes in the roots of 'Mianyou 838' rice, and these genes are significantly enriched in plant hormone synthesis and signaling pathways; it also up-regulates 93 transcription factor genes, mainly from the AP2/ERF-ERF and bHLH families^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.