NL13
NL13 is a Polo-like kinase 4 (PLK4) inhibitor with an IC50 value of 2.32 μM. NL13 can inhibit the viability of PC3 and DU145 prostate cancer cells, with IC50 values of 3.51 μM and 2.53 μM, respectively. NL13 can lead to the inactivation of the AKT signaling pathway by downregulating CCNB1/CDK1, inducing G2/M cell cycle arrest, and triggering apoptosis through the cleavage of caspase-9/caspase-3. In prostate cancer mice, NL13 can inhibit tumor growth.
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- 화학식: C22H19Cl2NO2
- 분자량:400.30
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
Chemical Information
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분자량 400.30
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화학식 C22H19Cl2NO2
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SMILES
ClC1=C(/C=C2CN(C(CC)=O)C/C(C\2=O)=C\C3=CC=CC=C3Cl)C=CC=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NL13 Related Classifications
HY-162895 Related Classifications
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