Jun - jun proto-oncogene Gene

Also Known as AP-1; Junc; c-jun

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16476

About Jun

Chromosome 4: 94,937,271-94,940,459 reverse strand.GRCm39:CM000997.3

This gene has 1 transcript (splice variant), 226 orthologues, 2 paralogues and is associated with 63 phenotypes.

Summary

Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in cellular response to anisomycin and positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus. Acts upstream of or within several processes, including animal organ development; negative regulation of protein autophosphorylation; and positive regulation of cell population proliferation. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; long bone; and sensory organ. Used to study pulmonary emphysema. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Jun Products (1)

mRNA Protein Name
NM_010591.2 NP_034721.1 transcription factor Jun

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA binding IDA
IDA: Inferred from direct assay
10076871 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
20442316 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
2138707 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
19303854 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
16847049 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
10352021 MGI
acts upstream of or within axon regeneration IMP
IMP: Inferred from mutant phenotype
15233917 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
16007074 MGI
involved in cellular response to anisomycin IDA
IDA: Inferred from direct assay
19584270 MGI
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
19303854 MGI
acts upstream of or within eyelid development in camera-type eye IMP
IMP: Inferred from mutant phenotype
25224220 MGI
acts upstream of or within leading edge cell differentiation IMP
IMP: Inferred from mutant phenotype
12791271 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
10352021 MGI
acts upstream of or within microglial cell activation IMP
IMP: Inferred from mutant phenotype
15233917 MGI
acts upstream of or within monocyte differentiation IMP
IMP: Inferred from mutant phenotype
18326819 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
10352021 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
16007074 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15233917 MGI
acts upstream of or within negative regulation of protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
16916642 MGI
acts upstream of or within outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
10352021 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
25224220 MGI
acts upstream of or within positive regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16847049 MGI
acts upstream of or within positive regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
25224220 MGI
acts upstream of or within positive regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
17182846 MGI
acts upstream of or within positive regulation of fibroblast proliferation IGI
IGI: Inferred from genetic interaction
17182846 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12798298 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19584270 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19303854 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
11818961 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
11818961 MGI
acts upstream of or within response to muscle stretch IDA
IDA: Inferred from direct assay
20442316 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
9098922 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in nucleus IDA
IDA: Inferred from direct assay
12050152 MGI
part of transcription factor AP-1 complex IPI
IPI: Inferred from physical interaction
1631061 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
12798298 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
17182846 MGI
part of transcription repressor complex IPI
IPI: Inferred from physical interaction
17182846 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Jun Protein Structure

Jun

Jun: pfam03957 (5 - 242)

bZIP_Jun

bZIP_Jun: cd14696 (256 - 316)

bZIP_Jun

bZIP_Jun: cd14696 (257 - 308)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

transcription factor Jun

  • AH119

  • AP1

  • Jun oncogene

  • V-jun avian sarcoma virus 17 oncogene homolog

  • activator protein 1

  • immediate early

  • jun A

  • proto-oncogene c-jun

  • transcription factor AP-1

  • transcription factor AP-1 subunit Jun

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-B1198 Piperonyl butoxide Inhibitor 98.0% Unkown
HY-B1451A Imidapril Inhibitor 99.0% Yes
HY-B1451 Imidapril hydrochloride Inhibitor 99.91% Yes
HY-B1198R Piperonyl butoxide (Standard) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (7)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-107600 IQ-3 Inhibitor 99.61% Phase 4
HY-145601 Tinengotinib Inhibitor 99.57% Phase 3
HY-14604 Xaliproden hydrochloride 98.40% Phase 3
HY-119820 Xaliproden free base / Phase 3
HY-12270 T-5224 Inhibitor 99.59% Phase 2
HY-138304 CC-90001 Inhibitor 99.98% Phase 2
HY-114250 Cantrixil Inducer 99.32% Phase 1

Pre-clinical Phase

Bioactive Molecules (86)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-13241 Ralimetinib dimesylate 99.97% Unkown
HY-162723 FOSL1 degrader 1 Degrader 99.66% Unkown
HY-13866 Ro 31-8220 mesylate 99.57% Unkown
HY-107598 JNK Inhibitor VIII Inhibitor 99.58% Unkown
HY-N2593 Isorhapontigenin 99.82% Unkown
HY-128326 ZAK-IN-1 Inhibitor 98.43% Unkown
HY-148510 HKB99 99.65% Unkown
HY-11010 AS601245 Inhibitor 98.19% Unkown
HY-114332 GNE-8505 Inhibitor 99.53% Unkown
HY-160469 INY-05-040 Degrader 98.54% Unkown
HY-W010983 SC-236 99.59% Unkown
HY-N5048 Galloylpaeoniflorin Inhibitor 98.30% Unkown
HY-N6983 Licoricesaponin G2 99.87% Unkown
HY-W020952 Palladium(Ⅱ) acetylacetonate 98.2% Unkown
HY-152142 DN-1289 Inhibitor 99.63% Unkown
HY-A0299 H-Gly-Pro-Hyp-OH Inhibitor 99.48% Unkown
HY-N0863 Methyl protodioscin 99.67% Unkown
HY-107599 AEG3482 Inhibitor 99.79% Unkown
HY-141582 Ceramide 3 Inhibitor 98.0% Unkown
HY-P10506 CMX-8933 Activator 99.77% Unkown
HY-W050000 OR-1855 Inhibitor 98.31% Unkown
HY-157403 Jun12682 Inhibitor 99.60% Unkown
HY-114331 DLK-IN-1 Inhibitor 98.27% Unkown
HY-P1190 c-JUN peptide 99.60% Unkown
HY-125838 J30-8 Inhibitor 99.51% Unkown
HY-107621 U0124 98.0% Unkown
HY-13866B Ro 31-8220 formic 99.76% Unkown
HY-169021 JNK-1-IN-3 Inhibitor 98.44% Unkown
HY-101287 MPT0B392 99.63% Unkown
HY-172920 Wnt/β-catenin-IN-6 98.34% Unkown
HY-B1198S Piperonyl butoxide-d9 Inhibitor 98.68% Unkown
HY-134975 NY2267 Inhibitor 98.53% Unkown
HY-10851 JNK-9L Inhibitor 98.06% Unkown
HY-118529 JUN-1111 Inhibitor 98.57% Unkown
HY-121683 (E)-2-Hexadecenal 99.9% Unkown
HY-168895 c-Fos-IN-1 97.24% Unkown
HY-171980 OZO-H 97.07% Unkown
HY-RS07054 JUN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07055 Jun Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13866A Ro 31-8220 / Unkown
HY-141582S Ceramide 3-d3 Inhibitor 98.0% Unkown
HY-113443 12(S)-HPETE Activator / Unkown
HY-12270S T-5224-d8 / Unkown
HY-151928 JNK3 inhibitor-3 Inhibitor / Unkown
HY-155593 JNK-1-IN-2 Inhibitor / Unkown
HY-162922 MAP4K4-IN-6 Inhibitor / Unkown
HY-164111 JNK-IN-17 Inhibitor / Unkown
HY-168337 SET-171 Inhibitor / Unkown
HY-168859 JNK3 inhibitor-9 Inhibitor / Unkown
HY-168895A (E,E)-c-Fos-IN-1 / Unkown
HY-168916 Jun13296 Inhibitor / Unkown
HY-169177 JNK-1-IN-4 Inhibitor / Unkown
HY-169314 JNK-IN-19 Inhibitor / Unkown
HY-176213 JNK2/3-IN-1 Inhibitor / Unkown
HY-178692 JNK-IN-25 Inhibitor / Unkown
HY-181263 Jun13698 Inhibitor / Unkown
HY-181556 JNK3-IN-10 / Unkown
HY-181662 DLK-IN-2 Inhibitor / Unkown
HY-181812 JNK2/MKK7 PPI-IN-1 Inhibitor / Unkown
HY-181993 JNK3-IN-11 Inhibitor / Unkown
HY-183010 VP1 ligand-1 / Unkown
HY-183011 CRBN ligand-901 / Unkown
HY-183014 VP1 ligand-Linker Conjugate 1 Ligand / Unkown
HY-183252 ICA-1S / Unkown
HY-184396 GR2-128 / Unkown
HY-D2898 Jun14157 Ligand / Unkown
HY-E70837 JNK2 Recombinant Human Active Protein Kinase / Unkown
HY-N1326 Santamarine 98.85% Unkown
HY-N1961 Ophiopogonin B 99.90% Unkown
HY-P10048 TAT-JIP Inhibitor / Unkown
HY-P11650 HE4-1 leech peptide Inhibitor / Unkown
HY-P4699 (Thr17)-c-Jun (11-23) / Unkown
HY-P6177 SGP8 Inhibitor / Unkown
HY-RS07056 Jun Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107091R Aspartyl-alanyl-diketopiperazine (Standard) Inhibitor / Unkown
HY-11010A AS601245 TFA Inhibitor / Unkown
HY-138844 3-AP-Me Activator / Unkown
HY-157305 Jun11165 Inhibitor / Unkown
HY-158751 Jun9-72-2 Inhibitor / Unkown
HY-159985 Jun13728 Inhibitor / Unkown
HY-174814 Jun15716 Inhibitor / Unkown
HY-174815 Jun15799 Inhibitor / Unkown
HY-175165 Jun6504 Inhibitor / Unkown
HY-182924 Jun15702 Inhibitor / Unkown
HY-B1451S Imidapril-d3 hydrochloride Inhibitor / Unkown
HY-P10401 TAT-GluR6-9c Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jun NCBI NCBI:3725