F2 - coagulation factor II, thrombin Gene
Also Known as PT; THPH1; RPRGL2
Species: Homo sapiens
About F2
This gene has 5 transcripts (splice variants), 87 orthologues, 1 paralogue and is associated with 7 phenotypes. Restricted expression toward liver (RPKM 385.8).
Summary
This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease Thrombin. The activated Thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure. [provided by RefSeq, May 2020]
F2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000506.5 | NP_000497.1 | prothrombin preproprotein |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables heparin binding |
IDA
IDA: Inferred from direct assay
|
20421939 | GOA |
| enables lipopolysaccharide binding |
IDA
IDA: Inferred from direct assay
|
20421939 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
2013320 | GOA |
| enables receptor ligand activity |
IDA
IDA: Inferred from direct assay
|
10761923 | GOA |
| enables serine-type endopeptidase activity |
IDA
IDA: Inferred from direct assay
|
1672265 | GOA |
| enables signaling receptor binding |
IPI
IPI: Inferred from physical interaction
|
8626514 | GOA |
| enables thrombospondin receptor activity |
IDA
IDA: Inferred from direct assay
|
2435757 | GOA |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| colocalizes with external side of plasma membrane |
IDA
IDA: Inferred from direct assay
|
20421939 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
9639571 | GOA |
F2 Protein Structure
Gla: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain (48 - 88)
Kringle: Kringle domain (108 - 186)
Kringle: Kringle domain (213 - 291)
Thrombin_light: Thrombin light chain (315 - 363)
Trypsin: Trypsin (364 - 613)
- 0
- 100
- 200
- 300
- 400
- 500
- 622 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
prothrombin |
|
F2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
F2 | P00734 | APP | Homo sapiens | P05067 | 32814053 | |
|
Intra
|
F2 | P00734 | APP | Homo sapiens | P05067 | 32814053 | |
|
Intra
|
F2 | P00734 | APP | Homo sapiens | P05067 | 32814053 | |
|
Intra
|
F2 | P00734 | THBD | Homo sapiens | P07204 | 14691232 | |
|
Cross
|
F2 | P00734 | q846v4_staau | Staphylococcus aureus | Q846V4 | 16230339 | |
|
Cross
|
F2 | P00734 | q846v4_staau | Staphylococcus aureus | Q846V4 | 16230339 |
F2 Antibodies
| Art. -Nr. | Produktname | Anwendung | Reactivity |
|---|---|---|---|
| HY-P81243 | F2 Antibody | WB, IP | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Prothrombin Deficiency, Congenital |
|
|
| Thrombophilia Due To Thrombin Defect |
|
|
| Pregnancy Loss, Recurrent 2 |
|
|
| Stroke, Ischemic |
|
|
| Prothrombin Deficiency |
|
|
| Thrombosis |
|
|
| Alcoholic Hepatitis |
|
|
| Vitamin K Deficiency Bleeding |
|
|
| Hepatic Encephalopathy |
|
|
| Cerebral Sinovenous Thrombosis |
|
|
| Portal Vein Thrombosis |
|
|
| Liver Disease |
|
|
| Hypersplenism |
|
|
| Antiphospholipid Syndrome |
|
|
| Hemorrhagic Disease |
|
|
| Acute Liver Failure |
|
|
| Disseminated Intravascular Coagulation |
|
|
| Thrombophilia |
|
|
| Pulmonary Embolism |
|
|
| Hepatorenal Syndrome |
|
|
| Hepatic Coma |
|
|
| Factor Vii Deficiency |
|
|
| Antithrombin Iii Deficiency |
|
|
| Papilledema |
|
|
| Portal Hypertension |
|
|
| Protein S Deficiency |
|
|
| Viral Hepatitis |
|
|
| Protein C Deficiency |
|
|
| Factor X Deficiency |
|
|
| Varicose Veins |
|
|
| Esophageal Varix |
|
|
| Liver Cirrhosis |
|
|
| Thrombophlebitis |
|
|
| Thrombophilia Due To Activated Protein C Resistance |
|
|
| Endocarditis |
|
|
| Hemophilia A |
|
|
| Afibrinogenemia, Congenital |
|
|
| Factor Xi Deficiency |
|
|
| Hemophilia B |
|
|
| Venous Insufficiency |
|
|
| Sagittal Sinus Thrombosis |
|
|
| Cerebral Palsy |
|
|
| Factor V Deficiency |
|
|
| Alcoholic Liver Cirrhosis |
|
|
| Vein Disease |
|
|
| Heparin-Induced Thrombocytopenia |
|
|
| Scott Syndrome |
|
|
| Retinal Artery Occlusion |
|
|
| Hemophilia |
|
|
| Nonarteritic Anterior Ischemic Optic Neuropathy |
|
|
| Choledocholithiasis |
|
|
| Purpura Fulminans |
|
|
| Hepatitis |
|
|
| Hepatitis B |
|
|
| Autoimmune Hepatitis |
|
|
| Bernard-Soulier Syndrome |
|
|
| Retinal Vein Occlusion |
|
|
| Kwashiorkor |
|
|
| Leptospirosis |
|
|
| Hepatic Vascular Disease |
|
|
| Livedoid Vasculitis |
|
|
| Thrombocytosis |
|
|
| Budd-Chiari Syndrome |
|
|
| Hepatitis A |
|
|
| Cholecystitis |
|
|
| Hemopericardium |
|
|
| Blood Coagulation Disease |
|
|
| Atrial Fibrillation |
|
|
| Thrombocytopenia |
|
|
| Purpura |
|
|
| Von Willebrand'S Disease |
|
|
| Sneddon Syndrome |
|
|
| Giant Hemangioma |
|
|
| Femoral Neuropathy |
|
|
| Gastroschisis |
|
|
| Pulmonary Artery Disease |
|
|
| Covid-19 |
|
|
| Hepatitis C |
|
|
| Intracranial Sinus Thrombosis |
|
|
| Hepatitis E |
|
|
| Cholestasis |
|
|
| Nonbacterial Thrombotic Endocarditis |
|
|
| Cholangitis |
|
|
| Active Peptic Ulcer Disease |
|
|
| Splenic Abscess |
|
|
| Hemoglobinuria |
|
|
| Osteonecrosis |
|
|
| Ascending Cholangitis |
|
|
| Pulmonary Edema |
|
|
| Hemopneumothorax |
|
|
| Pre-Eclampsia |
|
|
| Hellp Syndrome |
|
|
| Coumarin Resistance |
|
|
| Placental Insufficiency |
|
|
| Cerebrovascular Disease |
|
|
| Peritonitis |
|
|
| Thrombasthenia |
|
|
| Patent Foramen Ovale |
|
|
| Urolithiasis |
|
|
| Post-Thrombotic Syndrome |
|
|
| Intermittent Claudication |
|
|
| Acute Cholangitis |
|
|
| Sick Sinus Syndrome |
|
|
| Bilirubin Metabolic Disorder |
|
|
| Waterhouse-Friderichsen Syndrome |
|
|
| Hemolytic-Uremic Syndrome |
|
|
| Autoimmune Disease Of Cardiovascular System |
|
|
| Emphysematous Cholecystitis |
|
|
| Splenic Infarction |
|
|
| Eclampsia |
|
|
| Thoracic Outlet Syndrome |
|
|
| Alpha-1-Antitrypsin Deficiency |
|
|
| Compartment Syndrome |
|
|
| Hereditary Angioedema |
|
|
| Blood Protein Disease |
|
|
| Typhoid Fever |
|
|
| Intracranial Embolism |
|
|
| Cholesterol Embolism |
|
|
| Drug-Induced Hepatitis |
|
|
| Hyperhomocysteinemia |
|
|
| Hepatic Infarction |
|
|
| Homocysteinemia |
|
|
| Metabolic Acidosis |
|
|
| Acalculous Cholecystitis |
|
|
| Migraine With Aura |
|
|
| Intracranial Hypotension |
|
|
| Anterior Spinal Artery Syndrome |
|
|
| Dysfibrinogenemia, Congenital |
|
|
| Pericardium Disease |
|
|
| Endocardium Disease |
|
|
| Analbuminemia |
|
|
| Schistosomiasis |
|
|
| Biliary Atresia |
|
|
| Qualitative Platelet Defect |
|
|
| Splenic Sequestration |
|
|
| Polycythemia |
|
|
| Cardiac Tamponade |
|
|
| Toxoplasmosis |
|
|
| Internal Hemorrhoid |
|
|
| Common Bile Duct Disease |
|
|
| Ectodermal Dysplasia 12, Hypohidrotic/Hair/Tooth/Nail Type |
|
|
| Factor Viii Deficiency |
|
|
| Achenbach Syndrome |
|
|
| Acquired Von Willebrand Syndrome |
|
|
| Crimean-Congo Hemorrhagic Fever |
|
|
| Hemarthrosis |
|
|
| Epidural Abscess |
|
|
| Blue Toe Syndrome |
|
|
| Orbital Osteomyelitis |
|
|
| Hematocele Of Tunica Vaginalis Testis |
|
|
| Hemangioma |
|
|
| Nephrosclerosis |
|
|
| Beta-Thalassemia |
|
|
| Mastoiditis |
|
|
| Factor Xiii Deficiency |
|
|
| Central Retinal Artery Occlusion |
|
|
| Alpha-2-Plasmin Inhibitor Deficiency |
|
|
| Cavernous Sinus Thrombosis |
|
|
| Infective Endocarditis |
|
|
| Lemierre'S Syndrome |
|
|
| Primary Biliary Cholangitis |
|
|
| Polycythemia Vera |
|
|
| Hyperthyroidism |
|
|
| Abducens Palsy |
|
|
| Speech And Communication Disorders |
|
|
| Thalassemia |
|
|
| Branch Retinal Artery Occlusion |
|
|
| Synovial Angioma |
|
|
| Cecal Disease |
|
|
| Mitral Valve Stenosis |
|
|
| Maxillonasal Dysplasia, Binder Type |
|
|
| Heart Disease |
|
|
| Turner Syndrome |
|
|
| Angioedema |
|
|
| Vascular Disease |
|
|
| Mitral Valve Disease |
|
|
| Hepatic Tuberculosis |
|
|
| Splenic Disease |
|
|
| Intracranial Thrombosis |
|
|
| Subclavian Steal Syndrome |
|
|
| Arthritis |
|
|
| Subdural Empyema |
|
|
| Nephrolithiasis |
|
|
| Placental Abruption |
|
|
| Villonodular Synovitis |
|
|
| Systemic Lupus Erythematosus |
|
|
| Retinal Vascular Occlusion |
|
|
| Aortic Aneurysm |
|
|
| Kidney Cortex Necrosis |
|
|
| Paralytic Ileus |
|
|
| Acute Myocardial Infarction |
|
|
| Central Retinal Vein Occlusion |
|
|
| Ischemic Colitis |
|
|
| Cavernous Hemangioma |
|
|
| Uterine Inversion |
|
|
| Anuria |
|
|
| Blood Platelet Disease |
|
|
| Mediastinitis |
|
|
| Myocarditis |
|
|
| Hepatocellular Carcinoma |
|
|
| Splenic Artery Aneurysm |
|
|
| Tricuspid Valve Disease |
|
|
| Peptic Ulcer Disease |
|
|
| Primary Thrombocytopenia |
|
|
| Factor Xii Deficiency |
|
|
| Aspiration Pneumonia |
|
|
| Heart Conduction Disease |
|
|
| Tricuspid Valve Insufficiency |
|
|
| Intracranial Hypertension |
|
|
| Dieulafoy Lesion |
|
|
| Lateral Sinus Thrombosis |
|
|
| Pericardial Effusion |
|
|
| Ureteric Orifice Cancer |
|
|
| Pleural Empyema |
|
|
| Pyuria |
|
|
| Buerger Disease |
|
|
| Obstructive Jaundice |
|
|
| Angiodysplasia |
|
|
| Cranial Nerve Palsy |
|
|
| Acute Kidney Failure |
|
|
| Libman-Sacks Endocarditis |
|
|
| Volvulus Of Midgut |
|
|
| Abdominal Tuberculosis |
|
|
| Hypertensive Encephalopathy |
|
|
| Leech Infestation |
|
|
| Hypothyroidism |
|
|
| Aortic Valve Insufficiency |
|
|
| Hemorrhoid |
|
|
| Epstein-Barr Virus Hepatitis |
|
|
| Exanthem |
|
|
| Vertical Talus, Congenital |
|
|
| Atrial Heart Septal Defect |
|
|
| Severe Pre-Eclampsia |
|
|
| Klatskin'S Tumor |
|
|
| Mitral Valve Insufficiency |
|
|
| Pyridoxine Deficiency Anemia |
|
|
| Non-Severe Covid-19 |
|
|
| Myocardial Infarction |
|
|
| Acute Cor Pulmonale |
|
|
| Femoral Vein Thrombophlebitis |
|
|
| Transient Cerebral Ischemia |
|
|
| Coronavirus Infectious Disease |
|
|
| Cellulitis |
|
|
| Liver Leiomyosarcoma |
|
|
| Gastrointestinal Tuberculosis |
|
|
| Severe Covid-19 |
|
|
| Factitious Disorder |
|
|
| Nephrotic Syndrome |
|
|
| Malaria |
|
|
| Korean Hemorrhagic Fever |
|
|
| Suppurative Cholangitis |
|
|
| Drug Allergy |
|
|
| Acute Pulmonary Heart Disease |
|
|
| Ankylosing Spondylitis 1 |
|
|
| Late Congenital Syphilis |
|
|
| Arteriovenous Malformation |
|
|
| Protein-Deficiency Anemia |
|
|
| Neural Tube Defects |
|
|
| Ureterolithiasis |
|
|
| Critical Covid-19 |
|
|
| Nutritional Deficiency Disease |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Necrotizing Fasciitis |
|
|
| Heart Valve Disease |
|
|
| Thrombocytopenic Purpura, Autoimmune |
|
|
| Chronic Venous Insufficiency |
|
|
| Cardiomyopathy, Familial Hypertrophic, 20 |
|
|
| Wilson Disease |
|
|
| Autoimmune Disease Of Blood |
|
|
| Heart Septal Defect |
|
|
| Sclerosing Cholangitis |
|
|
| Hypersensitivity Vasculitis |
|
|
| Viral Pneumonia |
|
|
| Early Congenital Syphilis |
|
|
| Deficiency Anemia |
|
|
| Peliosis Hepatis |
|
|
| Reye Syndrome |
|
|
| Dic In Newborn |
|
|
| Bile Duct Disease |
|
|
| Protein-Losing Enteropathy |
|
|
| Intestinal Perforation |
|
|
| Cauda Equina Syndrome |
|
|
| Metal Metabolism Disorder |
|
|
| Aortic Dissection |
|
|
| Urinary Tract Infection |
|
|
| Plasma Protein Metabolism Disease |
|
|
| Biliary Tract Disease |
|
|
| Peripheral Vascular Disease |
|
|
| Supine Hypotensive Syndrome |
|
|
| Intestinal Obstruction |
|
|
| Alcohol Use Disorder |
|
|
| Hypertension, Essential |
|
|
| Klippel-Trenaunay-Weber Syndrome |
|
|
| Pleural Disease |
|
|
| Moyamoya Disease 1 |
|
|
| Amino Acid Metabolic Disorder |
|
|
| Central Nervous System Origin Vertigo |
|
|
| Chickenpox |
|
|
| Inflammatory Bowel Disease |
|
|
| Renal Pelvis Squamous Cell Carcinoma |
|
|
| Placenta Disease |
|
|
| Aortic Valve Disease 1 |
|
|
| Gastric Hemangioma |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Diabetes Mellitus |
|
|
| Autoimmune Disease Of Gastrointestinal Tract |
|
|
| Substance Abuse |
|
|
| Conjunctival Vascular Disease |
|
|
| Cholangitis, Primary Sclerosing |
|
|
| Respiratory Failure |
|
|
| Necrotizing Gastritis |
|
|
| Puerperal Pulmonary Embolism |
|
|
| Inguinal Hernia |
|
|
| Sclerosing Hepatic Carcinoma |
|
|
| Cortical Deafness |
|
|
| Hemoglobinopathy |
|
|
| Sickle Cell Anemia |
|
|
| Gilbert Syndrome |
|
|
| Pancytopenia |
|
|
| Splenic Tuberculosis |
|
|
| Behcet Syndrome |
|
|
| Hemolytic Uremic Syndrome, Atypical 1 |
|
|
| Acute Hemorrhagic Encephalitis |
|
|
| Patent Ductus Arteriosus 1 |
|
|
| Hemochromatosis, Type 1 |
|
|
| Intracranial Berry Aneurysm |
|
|
| Migraine With Or Without Aura 1 |
|
|
| Nervous System Disease |
|
|
| Skin Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | F2 | VGNC | VGNC:72464 |
| Felis catus | F2 | VGNC | VGNC:62023 |
| Rattus norvegicus | F2 | RGD | RGD:61996 |
| Canis familiaris | F2 | VGNC | VGNC:40547 |
| Mus musculus | F2 | MGD | MGI:88380 |
| Bos taurus | F2 | VGNC | VGNC:28682 |
| Others | F2 | NCBI |