Stem bromelain
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Stem bromelain (EC 3.4.22.32) is a cysteine protease and antibacterial agent. Stem bromelain can be isolated from the stem of the pineapple (Ananas comosus). Stem bromelain induces dose-dependent secretion of IL-12p70, and IL-6, induces Apoptosis, causes cleavage of full-length PARP protein, Caspase 3, and Caspase 9, increases Bax, and decreases Bcl-2. Stem bromelain possesses various fibrinolytic, antiedema, antithrombotic, and anti-inflammatory activities. Stem bromelain also exhibits in vivo antitumor and antileukemic activities, as well as antimetastatic effects. Stem bromelain has antimycobacterial activity. Stem bromelain provides protection against lead poisoning.
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- No. CAS: 37189-34-7
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Caspase 9 |
Caspase 3 |
Bax |
Bcl-2 |
IL-6 |
Stem bromelain (10-50 μg/mL; 12 h) causes Apoptosis, increases the expression of CD80, CD86, results in the dose-dependent secretion of IL-12p70, TNF-α, and IL-6 in peritoneal macrophages[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Peritoneal macrophages
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Concentration:10, 25, 50 μg/mL
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Incubation Time:12 h
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Result:Induced apoptosis and cleavage of full-length PARP protein.
Showed fragments of cleaved caspase 3 and cleaved caspase 9.
Increased the expression of Bax and decreased the expression of Bcl-2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
3.4.22.32
≥300U/mg soild
One unit is defined as the amount of enzyme that the absorbance of the trichloroacetic acid soluble from hydrolyzed casein per min product at 275 nm is comparable to that of 1 μg of tyrosine
Chemical Information
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No. CAS 37189-34-7
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Appearance Solid
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Color Off-white to light yellow
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SMILES
[Stem bromelain]
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Pavan R, et al. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. [Content Brief]
[2]. Báez R, et al. In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain. Planta Med. 2007 Oct;73(13):1377-83. [Content Brief]
[3]. Mahajan S, et al. Stem bromelain-induced macrophage apoptosis and activation curtail Mycobacterium tuberculosis persistence. J Infect Dis. 2012 Aug 1;206(3):366-76. [Content Brief]
[4]. Al-Otaibi WR, et al. Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats. Acta Biol Hung. 2015 Jun;66(2):149-60. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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