Csf1 - colony stimulating factor 1 (macrophage) Gene

Also Known as op; Csfm; MCSF; BAP025; Mhdabap25

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12977

Summary

Enables macrophage colony-stimulating factor receptor binding activity and protein homodimerization activity. Involved in several processes, including macrophage colony-stimulating factor signaling pathway; microglial cell proliferation; and positive regulation of gene expression. Acts upstream of or within several processes, including mammary gland development; osteoclast proliferation; and positive regulation of myeloid leukocyte differentiation. Located in extracellular space. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and hindlimb long bone. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Csf1 Products (3)

mRNA Protein Name
NM_001113529.1 NP_001107001.1 macrophage colony-stimulating factor 1 isoform 2 precursor
NM_001113530.1 NP_001107002.1 macrophage colony-stimulating factor 1 isoform 1 precursor
NM_007778.4 NP_031804.3 macrophage colony-stimulating factor 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
22902366 MGI
enables macrophage colony-stimulating factor receptor binding IPI
IPI: Inferred from physical interaction
2408759 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16267818 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
19017797 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of Ras protein signal transduction IDA
IDA: Inferred from direct assay
17053831 MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
10804170 MGI
involved in developmental process involved in reproduction IMP
IMP: Inferred from mutant phenotype
16237150 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: Inferred from mutant phenotype
9215625 MGI
involved in macrophage colony-stimulating factor signaling pathway IDA
IDA: Inferred from direct assay
19017797 MGI
acts upstream of macrophage differentiation IMP
IMP: Inferred from mutant phenotype
9215625 MGI
acts upstream of or within macrophage homeostasis IMP
IMP: Inferred from mutant phenotype
9215625 MGI
acts upstream of or within mammary duct terminal end bud growth IMP
IMP: Inferred from mutant phenotype
10804170 MGI
acts upstream of or within mammary gland fat development IMP
IMP: Inferred from mutant phenotype
10804170 MGI
involved in microglial cell proliferation IGI
IGI: Inferred from genetic interaction
23392676 MGI
acts upstream of monocyte differentiation IMP
IMP: Inferred from mutant phenotype
9215625 MGI
acts upstream of or within monocyte homeostasis IMP
IMP: Inferred from mutant phenotype
9215625 MGI
acts upstream of myeloid leukocyte migration IGI
IGI: Inferred from genetic interaction
17053831 MGI
acts upstream of or within neutrophil homeostasis IMP
IMP: Inferred from mutant phenotype
9215625 MGI
acts upstream of or within osteoclast differentiation IDA
IDA: Inferred from direct assay
17442941 MGI
acts upstream of osteoclast differentiation IGI
IGI: Inferred from genetic interaction
17053831 MGI
acts upstream of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
9215625 MGI
acts upstream of or within osteoclast proliferation IDA
IDA: Inferred from direct assay
22451653 MGI
acts upstream of or within positive regulation of Ras protein signal transduction IDA
IDA: Inferred from direct assay
17053831 MGI
acts upstream of or within positive regulation of cell-matrix adhesion IGI
IGI: Inferred from genetic interaction
17053831 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
30687013 MGI
acts upstream of or within positive regulation of leukocyte migration IGI
IGI: Inferred from genetic interaction
17053831 MGI
acts upstream of or within positive regulation of macrophage differentiation IMP
IMP: Inferred from mutant phenotype
9215625 MGI
acts upstream of or within positive regulation of monocyte differentiation IMP
IMP: Inferred from mutant phenotype
9215625 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
12865350 MGI
acts upstream of or within positive regulation of odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
12865350 MGI
acts upstream of or within positive regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
15657444 MGI
acts upstream of or within positive regulation of osteoclast differentiation IGI
IGI: Inferred from genetic interaction
17053831 MGI
acts upstream of or within positive regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
9215625 MGI
acts upstream of or within positive regulation of protein kinase activity IGI
IGI: Inferred from genetic interaction
17053831 MGI
acts upstream of or within regulation of ossification IMP
IMP: Inferred from mutant phenotype
12865350 MGI
Cellular Component GO Annotation Evidence References Source
part of CSF1-CSF1R complex IDA
IDA: Inferred from direct assay
19017797 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

macrophage colony-stimulating factor 1

  • osteopetrosis

Recombinant Csf1 Proteins

Cat. No. Product Name Accession Purity
HY-P7085 M-CSF Protein, Mouse P07141-1 (K33-P187) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7085A M-CSF Protein, Mouse (CHO) P07141-1 (K33-P187) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70553 M-CSF Protein, Mouse (HEK293) P07141-1 (K33-E262) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700222AF Animal-Free M-CSF Protein, Mouse (His) P07141-1 (K33-P187) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70263A M-CSF Protein, Mouse (HEK293, C-His) P07141-1 (K33-E262) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16749 Pexidartinib 99.64% Yes
HY-16749A Pexidartinib hydrochloride 99.82% Yes
HY-12297 Sulfatinib Inhibitor 99.52% Unkown

Clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-132166 Velzatinib Inhibitor 99.40% Phase 3
HY-109190 Seralutinib Inhibitor 99.94% Phase 3
HY-145601 Tinengotinib Inhibitor 99.57% Phase 3
HY-124526 Chiauranib Inhibitor 98.97% Phase 3
HY-153920A Pimicotinib hydrochloride Inhibitor / Phase 3
HY-D3284 CSF1 / Phase 3
HY-12768 Sotuletinib Inhibitor 99.97% Phase 2
HY-109086 Edicotinib Inhibitor 99.68% Phase 2
HY-19772 GSK3117391 Inhibitor 99.40% Phase 2
HY-159838 Enrupatinib Inhibitor 98.90% Phase 2
HY-161025 SYHA1813 Inhibitor 99.46% Phase 2
HY-136362 ARRY-382 Inhibitor 99.95% Phase 2
HY-159503A Segigratinib hydrochloride Inhibitor / Phase 2
HY-114153A PLX5622 hemifumarate Inhibitor 99.93% Phase 1
HY-111787 Elzovantinib Inhibitor 99.93% Phase 1
HY-101768 PRN1371 Inhibitor 99.78% Phase 1
HY-10204 OSI-930 98.33% Phase 1
Inhibitory Antibodies (6)
Cat. No. Product Name Effect
Purity Phase
HY-P99245 Emactuzumab Inhibitor 97.60% Phase 3
HY-P990043 Iluzanebart 98.63% Phase 2
HY-P99452 Axatilimab Inhibitor 99.59% Phase 2
HY-P99259 Cabiralizumab Inhibitor 99.73% Phase 2
HY-P99368 Lacnotuzumab Inhibitor 99.9% Phase 2
HY-P991048 AMG-820 Inhibitor 98% Phase 2

Pre-clinical Phase

Bioactive Molecules (71)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114153 PLX5622 Inhibitor 99.95% Unkown
HY-50905 Dovitinib Inhibitor 99.88% Yes
HY-12768A Sotuletinib hydrochloride Inhibitor 99.43% Unkown
HY-153920 Pimicotinib Inhibitor 99.92% Unkown
HY-10408 Ki20227 Inhibitor 99.51% Unkown
HY-101774 CSF1R-IN-1 Inhibitor 98.04% Unkown
HY-159108 AZ683 Inhibitor 98.57% Unkown
HY-117244 AZD7507 Inhibitor 99.57% Unkown
HY-147615 CSF1R-IN-12 98.75% Unkown
HY-122906 JTE-952 Inhibitor 99.86% Unkown
HY-152830 Adrixetinib 99.55% Unkown
HY-126297 c-Fms-IN-10 Inhibitor 98.63% Unkown
HY-139990 CSF1R-IN-3 Inhibitor 98.10% Unkown
HY-145809 FASN-IN-5 Inhibitor 99.98% Unkown
HY-112451 cFMS Receptor Inhibitor II Inhibitor 99.88% Unkown
HY-132935 BPR1R024 Inhibitor 98.50% Unkown
HY-160842 CSF1R-IN-24 Inhibitor 98.10% Unkown
HY-117273 AZ304 Inhibitor 99.77% Unkown
HY-119942 c-Fms-IN-8 Inhibitor 99.50% Unkown
HY-152830A Adrixetinib TFA 99.82% Unkown
HY-101526 GENZ-882706 Inhibitor / Unkown
HY-13075 c-Fms-IN-3 Inhibitor 98.83% Unkown
HY-132935A BPR1R024 mesylate Inhibitor / Unkown
HY-RS03228 CSF1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13493 AC710 Inhibitor 99.57% Unkown
HY-13496 JNJ-28312141 Inhibitor / Unkown
HY-RS16853 Csf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101034 CHMFL-ABL/KIT-155 / Unkown
HY-12768B Sotuletinib dihydrochloride Inhibitor / Unkown
HY-174366 JMC14 Inhibitor / Unkown
HY-10109A AS-605240 potassium Inhibitor / Unkown
HY-109086A Edicotinib hydrochloride Inhibitor / Unkown
HY-112446 ST638 Inhibitor / Unkown
HY-13496A JNJ-28312141 hydrochloride Inhibitor / Unkown
HY-144040 CSF1R-IN-4 / Unkown
HY-144041 CSF1R-IN-5 Inhibitor / Unkown
HY-144042 CSF1R-IN-6 / Unkown
HY-147608 CSF1R-IN-7 Inhibitor / Unkown
HY-147609 CSF1R-IN-8 Inhibitor / Unkown
HY-147610 CSF1R-IN-9 Inhibitor / Unkown
HY-147611 CSF1R-IN-10 Inhibitor / Unkown
HY-147616 CSF1R-IN-13 / Unkown
HY-147617 CSF1R-IN-14 / Unkown
HY-153012 Axl/Mer/CSF1R-IN-1 Inhibitor / Unkown
HY-153243 IACS-9439 Inhibitor / Unkown
HY-153277 Axl/Mer/CSF1R-IN-2 Inhibitor / Unkown
HY-155001 CSF1R-IN-15 Inhibitor / Unkown
HY-155550 CSF1R-IN-17 Antagonist / Unkown
HY-157422 CSF1R-IN-19 Inhibitor / Unkown
HY-157996 CSF1R-IN-21 Inhibitor / Unkown
HY-158050 PXB17 Inhibitor / Unkown
HY-158148 CSF1R-IN-23 Inhibitor / Unkown
HY-158363 CSF1R-IN-25 Inhibitor / Unkown
HY-161084 CSF1R-IN-18 Inhibitor / Unkown
HY-162309 CSF1R-IN-20 Inhibitor / Unkown
HY-162415 CSF1R-IN-22 / Unkown
HY-168954 CSF1R-IN-26 / Unkown
HY-176194 Antifibrotic agent 1 / Unkown
HY-183569 CSF1R-IN-27 Inhibitor / Unkown
HY-183931 NPA101.3 Inhibitor / Unkown
HY-187340 CSF1R/c-Kit-IN-1 Inhibitor / Unkown
HY-187341 CSF1R/c-Kit-IN-2 Inhibitor / Unkown
HY-D3217 Ctrl-CSF1 / Unkown
HY-RS03227 CSF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03229 Csf1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03230 Csf1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13493A AC710 Mesylate Inhibitor / Unkown
HY-164529 SJ-C1044 Inhibitor 98.63% Unkown
HY-174606 Human IL34 mRNA / Unkown
HY-174734 Human CSF1 mRNA / Unkown
HY-RS23294 Csf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990125 Anti-Mouse CSF1R/CD115 Antibody (AFS98) 99.38% Unkown
HY-P990257 Anti-Mouse CSF1 Antibody (5A1) Inhibitor 96.799% Unkown
HY-P990849 Anti-CSF1R/CD115 Antibody (2-4A5-4) Inhibitor / Unkown
HY-P991313 PD-360324 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Csf1 NCBI NCBI:1435