Igf1 - insulin-like growth factor 1 Gene

Also Known as Igf-1; Igf-I; C730016P09Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16000

Summary

This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. This gene is predominantly expressed in the liver and the encoded protein undergoes proteolytic processing to generate a disulfide-linked mature polypeptide. Transgenic disruption of this gene in mice results in reduced postnatal survival and severe growth retardation. Mice lacking the encoded protein exhibit generalized organ hypoplasia including underdevelopment of the central nervous system and developmental defects in bone, muscle and reproductive systems. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

Igf1 Products (5)

mRNA	Protein	Name
NM_001111274.1	NP_001104744.1	insulin-like growth factor I isoform 3 precursor
NM_001111275.2	NP_001104745.1	insulin-like growth factor I isoform 4 preproprotein
NM_001111276.1	NP_001104746.1	insulin-like growth factor I isoform 5 precursor
NM_001314010.1	NP_001300939.1	insulin-like growth factor I isoform 4 preproprotein
NM_010512.5	NP_034642.2	insulin-like growth factor I isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables insulin receptor binding	IDA IDA: Inferred from direct assay	21677284	MGI
enables insulin-like growth factor receptor binding	IPI IPI: Inferred from physical interaction	14566968	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7679139	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	35647546	MGI
enables receptor ligand activity	IGI IGI: Inferred from genetic interaction	32697974	MGI
enables transmembrane receptor protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	35647546	MGI
enables transmembrane receptor protein tyrosine kinase activator activity	IGI IGI: Inferred from genetic interaction	32697974	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18827067	MGI
acts upstream of or within blood vessel remodeling	IGI IGI: Inferred from genetic interaction	16691571	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	16691571	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	15059953	MGI
acts upstream of or within cell development	IMP IMP: Inferred from mutant phenotype	10465256	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	16691571	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16691571	MGI
acts upstream of or within cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	21677284	MGI
acts upstream of or within cellular response to insulin-like growth factor stimulus	IMP IMP: Inferred from mutant phenotype	21677284	MGI
acts upstream of cerebellar granule cell precursor proliferation	IDA IDA: Inferred from direct assay	10027293	MGI
acts upstream of or within chondroitin sulfate proteoglycan biosynthetic process	IDA IDA: Inferred from direct assay	17644814	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	20685873	MGI
acts upstream of or within exocrine pancreas development	IMP IMP: Inferred from mutant phenotype	12101187	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	12431371	MGI
acts upstream of or within glial cell differentiation	IMP IMP: Inferred from mutant phenotype	12574418	MGI
acts upstream of or within inner ear development	IDA IDA: Inferred from direct assay	21795542	MGI
acts upstream of or within insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	12805218	MGI
involved in insulin-like growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	8402901	MGI
acts upstream of or within lung alveolus development	IGI IGI: Inferred from genetic interaction	16691571	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	16691571	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	16691571	MGI
acts upstream of or within lung lobe morphogenesis	IGI IGI: Inferred from genetic interaction	16691571	MGI
acts upstream of or within lung lobe morphogenesis	IMP IMP: Inferred from mutant phenotype	16691571	MGI
acts upstream of or within lung vasculature development	IGI IGI: Inferred from genetic interaction	16691571	MGI
acts upstream of or within lung vasculature development	IMP IMP: Inferred from mutant phenotype	16691571	MGI
acts upstream of or within mammary gland development	IMP IMP: Inferred from mutant phenotype	15059953	MGI
acts upstream of or within multicellular organism growth	IDA IDA: Inferred from direct assay	12865332	MGI
acts upstream of or within myotube differentiation	IDA IDA: Inferred from direct assay	24722207	MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	16691571	MGI
acts upstream of or within negative regulation of androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18827067	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12904469	MGI
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	18977203	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	16691571	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16691571	MGI
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	19933931	MGI
acts upstream of or within negative regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	21677284	MGI
involved in negative regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	18977203	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	12574418	MGI
involved in osteoblast differentiation	IEP IEP: Inferred from expression pattern	16311053	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	21413931	MGI
acts upstream of or within positive regulation of cerebellar granule cell precursor proliferation	IDA IDA: Inferred from direct assay	10027293	MGI
involved in positive regulation of myelination	IDA IDA: Inferred from direct assay	28963396	MGI
acts upstream of or within positive regulation of myoblast proliferation	IMP IMP: Inferred from mutant phenotype	21406500	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	19208758	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15322112	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16691571	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16691571	MGI
acts upstream of or within positive regulation of type B pancreatic cell proliferation	IGI IGI: Inferred from genetic interaction	17636024	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	28683263	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	28683263	MGI
acts upstream of or within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP IMP: Inferred from mutant phenotype	10218945	MGI
acts upstream of or within prostate gland epithelium morphogenesis	IMP IMP: Inferred from mutant phenotype	17138659	MGI
acts upstream of or within prostate gland growth	IDA IDA: Inferred from direct assay	17138659	MGI
acts upstream of or within prostate gland growth	IMP IMP: Inferred from mutant phenotype	18827067	MGI
acts upstream of or within prostate gland stromal morphogenesis	IMP IMP: Inferred from mutant phenotype	17138659	MGI
acts upstream of or within regulation of establishment or maintenance of cell polarity	IDA IDA: Inferred from direct assay	7848824	MGI
acts upstream of or within regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	21677284	MGI
acts upstream of or within regulation of protein metabolic process	IGI IGI: Inferred from genetic interaction	7510770	MGI
acts upstream of or within regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	19744960	MGI
acts upstream of type B pancreatic cell proliferation	IGI IGI: Inferred from genetic interaction	17636024	MGI
acts upstream of or within type I pneumocyte differentiation	IMP IMP: Inferred from mutant phenotype	16691571	MGI
acts upstream of or within type II pneumocyte differentiation	IMP IMP: Inferred from mutant phenotype	16691571	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in exocytic vesicle	IDA IDA: Inferred from direct assay	21496647	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	7510770	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28683263	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	28683263	MGI
is active in neuronal dense core vesicle lumen	IDA IDA: Inferred from direct assay	28683263	MGI
is active in neuronal dense core vesicle lumen	IMP IMP: Inferred from mutant phenotype	28683263	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
insulin-like growth factor I	somatomedin

Recombinant Igf1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7070	IGF-I/IGF-1 Protein, Mouse	P05017-1 (G49-A118)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70698	IGF-I/IGF-1 Protein, Mouse (His)	P05017-1 (G49-A118)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74843	IGF-I/IGF-1 Protein, Mouse (P.pastoris)	P05017-1 (G49-A118)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70698AF	Animal-Free IGF-I/IGF-1 Protein, Mouse (His)	P05017-1 (G49-A118)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70698A	IGF-I/IGF-1 Protein, Mouse (N-His)	P05017-1 (G49-A118)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15656	Ceritinib	Inhibitor	99.95%	Yes
HY-15656A	Ceritinib dihydrochloride	Inhibitor	99.90%	Yes
HY-B0025	Voglibose	Inhibitor	98.0%	Unkown
HY-15656AR	Ceritinib dihydrochloride (Standard)	Inhibitor	/	Unkown
HY-15656R	Ceritinib (Standard)	Inhibitor	99.72%	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99165	Teprotumumab	Inhibitor	99.46%	Unkown
HY-P990084	Veligrotug		99.25%	Unkown

Clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15656B	Ceritinib mesylate	Inhibitor	/	Phase 4
HY-10191	Linsitinib	Inhibitor	99.90%	Phase 3
HY-15494	Picropodophyllin		99.85%	Phase 2
HY-10200	BMS-754807	Inhibitor	99.42%	Phase 2
HY-10199A	Ibutamoren	Agonist	99.84%	Phase 2
HY-153485	Cimdelirsen	Inhibitor	/	Phase 2
HY-153485A	Cimdelirsen sodium	Inhibitor	/	Phase 2
HY-19565	KW-2450 tosylate		/	Phase 2
HY-B0794	AZ7550	Inhibitor	97.09%	Phase 1
HY-15749	XL228	Inhibitor	99.64%	Phase 1
HY-13326	ASP3026		99.88%	Phase 1
HY-135749	BN201	Activator	99.89%	Phase 1
HY-113402B	Gamma-glutamylcysteine ammonium		/	Phase 1
HY-114913	Fenarimol	Inhibitor	99.78%	Phase 1

Inhibitory Antibodies (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99294	Ganitumab	Inhibitor	96.00%	Phase 3
HY-P99197	Figitumumab	Inhibitor	≥99.0%	Phase 3
HY-P99189	Cixutumumab	Inhibitor	99.63%	Phase 2
HY-P99274	Xentuzumab	Antagonist	99.71%	Phase 2
HY-P99284	Dalotuzumab		97.43%	Phase 2
HY-P99218	Robatumumab	Inhibitor	98.00%	Phase 2
HY-P99712	Lonigutamab		95.00%	Phase 2
HY-P99672	Istiratumab	Inhibitor	98.45%	Phase 2
HY-P991253	BIIB022	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (87)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108477	TMPyP4 tosylate	Inhibitor	98.0%	Unkown
HY-113402	Gamma-glutamylcysteine		98.53%	Unkown
HY-116624	MAZ51		99.96%	Unkown
HY-50866	NVP-AEW541		99.71%	Unkown
HY-W015924	2-Hydroxyisobutyric acid		98.0%	Unkown
HY-10262	BMS-536924		99.83%	Unkown
HY-15609	AZD-3463		99.31%	Unkown
HY-13203	NVP-TAE 226		99.77%	Unkown
HY-N7922	Urolithin M5	Inhibitor	97.31%	Unkown
HY-10252	NVP-ADW742		99.30%	Unkown
HY-10253	AG1024		99.50%	Unkown
HY-W074890	Palmitoylglycine	Modulator	99.84%	Unkown
HY-N0908	Ginsenoside Rg5		99.88%	Unkown
HY-10524	GSK1904529A		99.03%	Unkown
HY-113402A	Gamma-glutamylcysteine TFA		96.68%	Unkown
HY-N1990	Gypenoside XLIX		99.88%	Unkown
HY-P5133	Synstatin (92-119)	Inhibitor	97.61%	Unkown
HY-P3226	JB-1		99.63%	Unkown
HY-19820A	NSC45586 sodium		98.0%	Unkown
HY-100349	SU4312	Inhibitor	99.74%	Unkown
HY-B0794B	AZ7550 Mesylate	Inhibitor	98.70%	Unkown
HY-135436	AG 538	Inhibitor	98.99%	Unkown
HY-P5438	Srctide	Substrate	99.71%	Unkown
HY-135680	I-OMe-Tyrphostin AG 538	Inhibitor	98.03%	Unkown
HY-18785	Indirubin Derivative E804	Inhibitor	98.54%	Unkown
HY-P10044	IGF1Rtide		99.53%	Unkown
HY-W112938	TMPyP tetrachloride	Inhibitor	98.30%	Unkown
HY-113402R	Gamma-glutamylcysteine (Standard)		98.14%	Unkown
HY-130687A	Psicose		99.90%	Unkown
HY-139783	3-Campholenyl-2-butanol	Inducer	98.0%	Unkown
HY-145110	IGF-1R inhibitor-2	Inhibitor	98.07%	Unkown
HY-P2090A	Angiopeptin TFA		99.01%	Unkown
HY-158315	NZ-97	Inhibitor	99.43%	Unkown
HY-RS06614	IGF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-156914	IGF-1R/SRC-IN-1	Inhibitor	99.86%	Unkown
HY-177760	PrCP-7414		/	Unkown
HY-125102	AZ12253801	Inhibitor	/	Unkown
HY-135562	Ascofuranone	Inhibitor	96%	Unkown
HY-15656S	Ceritinib-d7	Inhibitor	98.00%	Unkown
HY-B0794A	AZ7550 hydrochloride	Inhibitor	98.66%	Unkown
HY-113402AR	Gamma-glutamylcysteine TFA (Standard)		95.17%	Unkown
HY-15494R	Picropodophyllin (Standard)		99.70%	Unkown
HY-174655	Human IGF1 mRNA		/	Unkown
HY-21291	SU-4313	Modulator	99.31%	Unkown
HY-B0794S	AZ7550-d5	Inhibitor	/	Unkown
HY-N6611	Chimaphilin	Inhibitor	99.80%	Unkown
HY-50866B	NVP-AEW541 dihydrochloride		/	Unkown
HY-100038	AZD9362	Inhibitor	/	Unkown
HY-10252A	cis-NVP-ADW742	Inhibitor	/	Unkown
HY-10438	BMS-577098	Inhibitor	/	Unkown
HY-108230	ALK-IN-12	Inhibitor	/	Unkown
HY-118046	GSK2163632A	Inhibitor	/	Unkown
HY-13312A	GTx-134		/	Unkown
HY-15494S	Picropodophyllin-d3		/	Unkown
HY-15494S1	Picropodophyllin-d6		/	Unkown
HY-162506	IGF-1R inhibitor-3	Inhibitor	/	Unkown
HY-167854	KW-2450 free base	Inhibitor	/	Unkown
HY-169572	IGF-1R inhibitor-5	Inhibitor	/	Unkown
HY-169600	IGF-1R inhibitor-4	Inhibitor	/	Unkown
HY-17603A	(E)-Belizatinib	Inhibitor	/	Unkown
HY-177622	Cibrigirsen	Inhibitor	/	Unkown
HY-177622A	Cibrigirsen sodium	Inhibitor	/	Unkown
HY-178460	BRK/PTK6-IN-1	Inhibitor	/	Unkown
HY-179732	PROTAC ALK degrader-4		/	Unkown
HY-180972	PROTAC EML4-ALK Degrader-2	Inhibitor	/	Unkown
HY-182264	Masoprocol tetrapivalate	Inhibitor	/	Unkown
HY-187257S	[U-15N]-IGF-1		/	Unkown
HY-187258S	[U-13C,15N]-IGF-1		/	Unkown
HY-402309	IGF-1R modulator 1	Modulator	/	Unkown
HY-E70730	INSR Recombinant Human Active Protein Kinase		/	Unkown
HY-P11431	Cyclo(Gly-Pro)		/	Unkown
HY-P2090	Angiopeptin		/	Unkown
HY-RS06615	IGF1R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06616	Igf1r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06617	Igf1r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-100349A	cis-SU4312	Inhibitor	/	Unkown
HY-117885	PF-5177624	Inhibitor	/	Unkown
HY-119112A	LY 379196	Inhibitor	/	Unkown
HY-138257A	(R)-Indeloxazine benzenesulfonate	Inhibitor	/	Unkown
HY-14357	BMS 695735	Inhibitor	/	Unkown
HY-168616	CL-A3-7	Inhibitor	/	Unkown
HY-174654	Human IGF1R mRNA		/	Unkown
HY-174721	Human EGFR mRNA		/	Unkown
HY-180210	Ghrelin receptor full agonist-3	Agonist	/	Unkown
HY-RS16528	Igf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22959	Igf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W749516	Voglibose-13C3	Inhibitor	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991042	Anti-IGFBP2 Antibody (M14)	Antagonist	≥99.0%	Unkown
HY-P991134	Elegrobart	Inhibitor	95.27%	Unkown
HY-P990966	Redalsomatropin alfa		/	Unkown
HY-P991255	VRDN-002	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Igf1	NCBI	NCBI:3479