Igf1 - insulin-like growth factor 1 Gene

Also Known as IGF

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24482

Summary

Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of cell death; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); congenital diaphragmatic hernia; folic acid deficiency anemia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (Insulin like growth factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Igf1 Products (4)

mRNA Protein Name
NM_001082477.2 NP_001075946.2 insulin-like growth factor I isoform a preproprotein
NM_001082478.1 NP_001075947.1 insulin-like growth factor I isoform c preproprotein
NM_001082479.1 NP_001075948.1 insulin-like growth factor I isoform d preproprotein
NM_178866.4 NP_849197.3 insulin-like growth factor I isoform b preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone activity IDA
IDA: Inferred from direct assay
16083987 RGD
enables insulin-like growth factor receptor binding IDA
IDA: Inferred from direct assay
16083987 RGD
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
17023532 RGD
enables steroid binding IDA
IDA: Inferred from direct assay
16083987 RGD
Biological Process GO Annotation Evidence References Source
involved in bone development IEP
IEP: Inferred from expression pattern
24735836 RGD
involved in cardiac atrium development IEP
IEP: Inferred from expression pattern
15486038 RGD
involved in cellular response to Thyroglobulin triiodothyronine IEP
IEP: Inferred from expression pattern
8674839 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
19853640 RGD
involved in cellular response to electrical stimulus IEP
IEP: Inferred from expression pattern
18661273 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
17531559 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
20013160 RGD
involved in cellular response to nicotine IEP
IEP: Inferred from expression pattern
23454400 RGD
involved in cellular response to progesterone stimulus IEP
IEP: Inferred from expression pattern
19853640 RGD
involved in cellular response to zinc ion starvation IEP
IEP: Inferred from expression pattern
21893222 RGD
involved in cranial suture morphogenesis IEP
IEP: Inferred from expression pattern
10597685 RGD
involved in detection of mechanical stimulus involved in sensory perception IMP
IMP: Inferred from mutant phenotype
21037532 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
17123939 RGD
involved in insulin-like growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
16083987 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
16650607 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
17103039 RGD
involved in negative regulation of cholangiocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
17531559 RGD
involved in negative regulation of extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
17023532 RGD
involved in negative regulation of immune system process IMP
IMP: Inferred from mutant phenotype
8575560 RGD
involved in negative regulation of muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16699953 RGD
involved in negative regulation of oligodendrocyte apoptotic process IDA
IDA: Inferred from direct assay
17577243 RGD
involved in negative regulation of smooth muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
20724525 RGD
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
20724525 RGD
involved in positive regulation of blood vessel endothelial cell migration IGI
IGI: Inferred from genetic interaction
28315330 RGD
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
15544842 RGD
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
16869890 RGD
involved in positive regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
16897348 RGD
involved in positive regulation of glial cell proliferation IDA
IDA: Inferred from direct assay
24262632 RGD
involved in positive regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
16897348 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
17023532 RGD
involved in positive regulation of steroid hormone biosynthetic process IDA
IDA: Inferred from direct assay
17023532 RGD
involved in positive regulation of vascular endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
28315330 RGD
involved in regulation of calcium ion transport IDA
IDA: Inferred from direct assay
16763033 RGD
involved in regulation of cell population proliferation IDA
IDA: Inferred from direct assay
16083987 RGD
involved in regulation of translation IMP
IMP: Inferred from mutant phenotype
15544842 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
19382144 RGD
involved in response to caffeine IEP
IEP: Inferred from expression pattern
22995397 RGD
involved in response to epidermal growth factor IEP
IEP: Inferred from expression pattern
2003595 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
11201330 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
17645580 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
24239160 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
19359918 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
21750148 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
19766709 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19180987 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
11834488 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
23454400 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
2383530 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
17626604 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19327374 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
7524339 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
15917159 RGD
involved in response to thyroid hormone IEP
IEP: Inferred from expression pattern
8532765 RGD
involved in retinal cell apoptotic process IDA
IDA: Inferred from direct assay
10973501 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
15990634 RGD
located in interstitial matrix IDA
IDA: Inferred from direct assay
15544842 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
21037532 RGD
located in platelet alpha granule IDA
IDA: Inferred from direct assay
9449625 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin-like growth factor I

  • IGF-I

  • somatomedin

Recombinant Igf1 Proteins

Cat. No. Product Name Accession Purity
HY-P7203 IGF-I/IGF-1 Protein, Rat P08025 (G49-A118) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15656 Ceritinib Inhibitor 99.95% Yes
HY-15656A Ceritinib dihydrochloride Inhibitor 99.90% Yes
HY-B0025 Voglibose Inhibitor 98.0% Unkown
HY-15656AR Ceritinib dihydrochloride (Standard) Inhibitor / Unkown
HY-15656R Ceritinib (Standard) Inhibitor 99.72% Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99165 Teprotumumab Inhibitor 99.46% Unkown
HY-P990084 Veligrotug 99.25% Unkown

Clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Phase
HY-15656B Ceritinib mesylate Inhibitor / Phase 4
HY-10191 Linsitinib Inhibitor 99.90% Phase 3
HY-15494 Picropodophyllin 99.85% Phase 2
HY-10200 BMS-754807 Inhibitor 99.42% Phase 2
HY-10199A Ibutamoren Agonist 99.84% Phase 2
HY-153485 Cimdelirsen Inhibitor / Phase 2
HY-153485A Cimdelirsen sodium Inhibitor / Phase 2
HY-19565 KW-2450 tosylate / Phase 2
HY-B0794 AZ7550 Inhibitor 97.09% Phase 1
HY-15749 XL228 Inhibitor 99.64% Phase 1
HY-13326 ASP3026 99.88% Phase 1
HY-135749 BN201 Activator 99.89% Phase 1
HY-113402B Gamma-glutamylcysteine ammonium / Phase 1
HY-114913 Fenarimol Inhibitor 99.78% Phase 1
Inhibitory Antibodies (9)
Cat. No. Product Name Effect
Purity Phase
HY-P99294 Ganitumab Inhibitor 96.00% Phase 3
HY-P99197 Figitumumab Inhibitor ≥99.0% Phase 3
HY-P99189 Cixutumumab Inhibitor 99.63% Phase 2
HY-P99274 Xentuzumab Antagonist 99.71% Phase 2
HY-P99284 Dalotuzumab 97.43% Phase 2
HY-P99218 Robatumumab Inhibitor 98.00% Phase 2
HY-P99712 Lonigutamab 95.00% Phase 2
HY-P99672 Istiratumab Inhibitor 98.45% Phase 2
HY-P991253 BIIB022 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (87)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108477 TMPyP4 tosylate Inhibitor 98.0% Unkown
HY-113402 Gamma-glutamylcysteine 98.53% Unkown
HY-116624 MAZ51 99.96% Unkown
HY-50866 NVP-AEW541 99.71% Unkown
HY-W015924 2-Hydroxyisobutyric acid 98.0% Unkown
HY-10262 BMS-536924 99.83% Unkown
HY-15609 AZD-3463 99.31% Unkown
HY-13203 NVP-TAE 226 99.77% Unkown
HY-N7922 Urolithin M5 Inhibitor 97.31% Unkown
HY-10252 NVP-ADW742 99.30% Unkown
HY-10253 AG1024 99.50% Unkown
HY-W074890 Palmitoylglycine Modulator 99.84% Unkown
HY-N0908 Ginsenoside Rg5 99.88% Unkown
HY-10524 GSK1904529A 99.03% Unkown
HY-113402A Gamma-glutamylcysteine TFA 96.68% Unkown
HY-N1990 Gypenoside XLIX 99.88% Unkown
HY-P5133 Synstatin (92-119) Inhibitor 97.61% Unkown
HY-P3226 JB-1 99.63% Unkown
HY-19820A NSC45586 sodium 98.0% Unkown
HY-100349 SU4312 Inhibitor 99.74% Unkown
HY-B0794B AZ7550 Mesylate Inhibitor 98.70% Unkown
HY-135436 AG 538 Inhibitor 98.99% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-135680 I-OMe-Tyrphostin AG 538 Inhibitor 98.03% Unkown
HY-18785 Indirubin Derivative E804 Inhibitor 98.54% Unkown
HY-P10044 IGF1Rtide 99.53% Unkown
HY-W112938 TMPyP tetrachloride Inhibitor 98.30% Unkown
HY-113402R Gamma-glutamylcysteine (Standard) 98.14% Unkown
HY-130687A Psicose 99.90% Unkown
HY-139783 3-Campholenyl-2-butanol Inducer 98.0% Unkown
HY-145110 IGF-1R inhibitor-2 Inhibitor 98.07% Unkown
HY-P2090A Angiopeptin TFA 99.01% Unkown
HY-158315 NZ-97 Inhibitor 99.43% Unkown
HY-RS06614 IGF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156914 IGF-1R/SRC-IN-1 Inhibitor 99.86% Unkown
HY-177760 PrCP-7414 / Unkown
HY-125102 AZ12253801 Inhibitor / Unkown
HY-135562 Ascofuranone Inhibitor 96% Unkown
HY-15656S Ceritinib-d7 Inhibitor 98.00% Unkown
HY-B0794A AZ7550 hydrochloride Inhibitor 98.66% Unkown
HY-113402AR Gamma-glutamylcysteine TFA (Standard) 95.17% Unkown
HY-15494R Picropodophyllin (Standard) 99.70% Unkown
HY-174655 Human IGF1 mRNA / Unkown
HY-21291 SU-4313 Modulator 99.31% Unkown
HY-B0794S AZ7550-d5 Inhibitor / Unkown
HY-N6611 Chimaphilin Inhibitor 99.80% Unkown
HY-50866B NVP-AEW541 dihydrochloride / Unkown
HY-100038 AZD9362 Inhibitor / Unkown
HY-10252A cis-NVP-ADW742 Inhibitor / Unkown
HY-10438 BMS-577098 Inhibitor / Unkown
HY-108230 ALK-IN-12 Inhibitor / Unkown
HY-118046 GSK2163632A Inhibitor / Unkown
HY-13312A GTx-134 / Unkown
HY-15494S Picropodophyllin-d3 / Unkown
HY-15494S1 Picropodophyllin-d6 / Unkown
HY-162506 IGF-1R inhibitor-3 Inhibitor / Unkown
HY-167854 KW-2450 free base Inhibitor / Unkown
HY-169572 IGF-1R inhibitor-5 Inhibitor / Unkown
HY-169600 IGF-1R inhibitor-4 Inhibitor / Unkown
HY-17603A (E)-Belizatinib Inhibitor / Unkown
HY-177622 Cibrigirsen Inhibitor / Unkown
HY-177622A Cibrigirsen sodium Inhibitor / Unkown
HY-178460 BRK/PTK6-IN-1 Inhibitor / Unkown
HY-179732 PROTAC ALK degrader-4 / Unkown
HY-180972 PROTAC EML4-ALK Degrader-2 Inhibitor / Unkown
HY-182264 Masoprocol tetrapivalate Inhibitor / Unkown
HY-187257S [U-15N]-IGF-1 / Unkown
HY-187258S [U-13C,15N]-IGF-1 / Unkown
HY-402309 IGF-1R modulator 1 Modulator / Unkown
HY-E70730 INSR Recombinant Human Active Protein Kinase / Unkown
HY-P11431 Cyclo(Gly-Pro) / Unkown
HY-P2090 Angiopeptin / Unkown
HY-RS06615 IGF1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06616 Igf1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06617 Igf1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100349A cis-SU4312 Inhibitor / Unkown
HY-117885 PF-5177624 Inhibitor / Unkown
HY-119112A LY 379196 Inhibitor / Unkown
HY-138257A (R)-Indeloxazine benzenesulfonate Inhibitor / Unkown
HY-14357 BMS 695735 Inhibitor / Unkown
HY-168616 CL-A3-7 Inhibitor / Unkown
HY-174654 Human IGF1R mRNA / Unkown
HY-174721 Human EGFR mRNA / Unkown
HY-180210 Ghrelin receptor full agonist-3 Agonist / Unkown
HY-RS16528 Igf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22959 Igf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W749516 Voglibose-13C3 Inhibitor / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991042 Anti-IGFBP2 Antibody (M14) Antagonist ≥99.0% Unkown
HY-P991134 Elegrobart Inhibitor 95.27% Unkown
HY-P990966 Redalsomatropin alfa / Unkown
HY-P991255 VRDN-002 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Igf1 NCBI NCBI:3479