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SCLY - selenocysteine lyase Gene

Also Known as SCL; hSCL

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 51540

About SCLY

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:238,061,001-238,099,413 (from NCBI)

This gene has 21 transcripts (splice variants), 196 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 6.4), liver (RPKM 4.7) and 25 other tissues.

Summary

Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]

SCLY Products (1)

mRNA	Protein	Name
NM_016510.7	NP_057594.5	selenocysteine lyase

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCLY Protein Structure

Aminotran_5

0
100
200
300
400
453 a.a.

Protein Preferred Names	Protein Names
selenocysteine lyase

SCLY Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SCLY	Q96I15	LNX2	Homo sapiens	Q8N448	Y2H Array	29892012
Intra	SCLY	Q96I15	LNX2	Homo sapiens	Q8N448	Y2H Array	31515488
Intra	SCLY	Q96I15	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SCLY Proteins

製品番号	製品名	アクセッション番号	純度
HY-P71280	SCLY Protein, Human (His)	Q96I15-1 (M1-A445)	≥ 95%, as determined by reducing SDS-PAGE.

Diseases	Alias
Glomerulonephritis	Bright'S Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (15)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-B0361	Aspartame		99.70%	Unkown
HY-17474	Parecoxib	Inhibitor	99.29%	Yes
HY-132587	Fitusiran		98.70%	Unkown
HY-17474A	Parecoxib Sodium	Inhibitor	99.82%	Yes
HY-B0561R	Spironolactone (Standard)		98.55%	Unkown
HY-17509	Deracoxib		99.96%	Unkown
HY-132587A	Fitusiran sodium		95.08%	Unkown
HY-B0455A	Lomefloxacin		99.99%	Unkown
HY-B0318A	Metronidazole hydrochloride		98.44%	Yes
HY-B1341	Norethynodrel	Activator	90.53%	Unkown
HY-132587C	Fitusiran sodium scrambled negative control	Activator	/	Unkown
HY-132587D	FAM labled Fitusiran sodium		/	Unkown
HY-132587E	Cy3 labled Fitusiran sodium		/	Unkown
HY-B0455AR	Lomefloxacin (Standard)	Inhibitor	/	Unkown
HY-B0455B	Lomefloxacin (aspartate)	Inhibitor	/	Unkown

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-P99590	Sotatercept		99.94%	Unkown

Clinical Phase

Bioactive Molecules (16)

製品番号	製品名	製品効果	純度	Phase
HY-14718	Resminostat	Inhibitor	99.44%	Phase 4
HY-14398GL	Celecoxib (GMP Like)	Inhibitor	/	Phase 4
HY-170554	ABBV-706	Inhibitor	99.71%	Phase 3
HY-132257	Rovalpituzumab tesirine	Inhibitor	97.47%	Phase 3
HY-U00232	Bidisomide	Ligand	99.62%	Phase 3
HY-136657	SC-43		99.01%	Phase 2
HY-16012	Domatinostat tosylate		99.66%	Phase 2
HY-106395	Telinavir	Inhibitor	98.16%	Phase 2
HY-100934	SC-9	Activator	99.33%	Phase 2
HY-14908A	Vidofludimus hemicalcium		/	Phase 2
HY-19046	AGN-2979 hydrochloride	Inhibitor	/	Phase 2
HY-19080	SC-45662	Inhibitor	/	Phase 2
HY-19500	SC-75416	Inhibitor	/	Phase 2
HY-16451	SC-49483		/	Phase 2
HY-19897	4SC-203	Inhibitor	98.98%	Phase 1
HY-112739	SC-41930	Agonist	/	Phase 1