TL13-112
Based on 2 publication(s) in Google Scholar
TL13-112 is a ALK PROTAC degrader. TL13-112 degrades the NPM-ALK protein by recruiting the CRBN E3 ligase, thereby blocking oncogenic signal transduction such as STAT3, ERK and AKT, and relieving the transcriptional repression of CD45, CCR7 and PI3Kδ. TL13-112 can be used in related research on anaplastic large cell lymphoma.
(Pink: Anaplastic lymphoma kinase (ALK) ligand (HY-15656); Blue: Cereblon ligand (HY-41547); Black: linker).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.01%
- CAS 番号: 2229037-19-6
- 分子式: C49H60ClN9O10S
- 分子量:1002.57
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 TL13-112
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生物活性
製品説明
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p110δ |
STAT3 |
CCR7 |
Cereblon |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SR | IC50 |
5.9 nM
Compound: Cpd 11
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Antiproliferative activity against ALK positive human SR cells
Antiproliferative activity against ALK positive human SR cells
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[PMID: 33751979] |
体外実験
TL13-112 (100 nM; 12 h) induces potent degradation of ALK protein in TS and JB6 cells and specifically reduces the interaction between NPM-ALK and PTPN1/PTPN2[1].
TL13-112 (10-50 nM; 8-48 h) significantly degrades ALK protein in a time-dependent manner in TS, SU-DHL1 and JB6 cells, inhibits the level of downstream pALK (Y1604), and upregulates the cell surface expression and mRNA transcription levels of CD45 and CD45RO[2].
TL13-112 (50-100 nM; 8-72 h) degrades ALK protein in KARPAS-299, DEL, COST, and SU-DHL1 cells, upregulates the expression of PI3Kδ (p110δ) protein, and significantly upregulates the cell surface expression of CCR7 mRNA and protein, as well as the cell surface fluorescence intensity of CCR7[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TS, SU-DHL1, JB6 cells
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Concentration:10, 25, 50 nM
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Incubation Time:8 h, 16 h, 24 h, 48 h
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Result:Significantly degraded ALK protein in a time-dependent manner and inhibited downstream pALK (Y1604) levels.
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Cell Line:TS and JB6 cells
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Concentration:10, 25, 50 nM
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Incubation Time:8 h
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Result:Upregulated CD45 and CD45RO mRNA transcription levels.
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Cell Line:KARPAS-299, DEL, COST cells
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Concentration:100 nM
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Incubation Time:8 h, 16 h
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Result:Degraded ALK protein and upregulated PI3Kδ (p110δ) and CCR7 protein expression.
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Cell Line:KARPAS-299, DEL, COST cells
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Concentration:100 nM
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Incubation Time:8 h, 16 h
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Result:Significantly upregulated CCR7 mRNA.
化学情報
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CAS 番号 2229037-19-6
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性状 Solid
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分子量 1002.57
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分子式 C49H60ClN9O10S
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Color Light yellow to yellow
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SMILES
O=C(NCCOCCOCCN1CCC(C2=CC(OC(C)C)=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)C=C2C)CC1)CNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Sci Transl Med
Targeting CCR7-PI3Kγ overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma. [Abstract]2023 Jun 28;15(702):eabo3826. PMID: 37379367 -
bioRxiv
2025 Nov 30:2025.11.26.690562. PMID: 41394586
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (99.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Karaca Atabay E, et al. Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma. Blood. 2022 Feb 3;139(5):717-731. [Content Brief]
[3]. Mastini C, et al. Targeting CCR7-PI3Kγ overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma. Science translational medicine. 2023 Jun 28;15(702):eabo3826. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9974 mL | 4.9872 mL | 9.9744 mL | 24.9359 mL |
| 5 mM | 0.1995 mL | 0.9974 mL | 1.9949 mL | 4.9872 mL | |
| 10 mM | 0.0997 mL | 0.4987 mL | 0.9974 mL | 2.4936 mL | |
| 15 mM | 0.0665 mL | 0.3325 mL | 0.6650 mL | 1.6624 mL | |
| 20 mM | 0.0499 mL | 0.2494 mL | 0.4987 mL | 1.2468 mL | |
| 25 mM | 0.0399 mL | 0.1995 mL | 0.3990 mL | 0.9974 mL | |
| 30 mM | 0.0332 mL | 0.1662 mL | 0.3325 mL | 0.8312 mL | |
| 40 mM | 0.0249 mL | 0.1247 mL | 0.2494 mL | 0.6234 mL | |
| 50 mM | 0.0199 mL | 0.0997 mL | 0.1995 mL | 0.4987 mL | |
| 60 mM | 0.0166 mL | 0.0831 mL | 0.1662 mL | 0.4156 mL | |
| 80 mM | 0.0125 mL | 0.0623 mL | 0.1247 mL | 0.3117 mL |
TL13-112 関連分類
HY-123919 関連分類
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