Cyproheptadine-d3
Cyproheptadine-d3 is the d3-labeled Cyproheptadine (HY-B1622). Cyproheptadine acts as a p38 MAP kinase activator, CHK2 activator, histamine H1 receptor inhibitor and serotonin receptor inhibitor. Cyproheptadine mediates cell cycle arrest via G1 phase arrest, G1/S transition arrest, G0/G1 phase arrest, reduced expression of cyclins D1/D2/D3, upregulated expression of HBP1, p16, p21, p27, and decreased phosphorylation of retinoblastoma protein. Cyproheptadine induces Apoptosis by increasing PARP and cleaved PARP, as well as activating the mitochondrial caspase pathway. Cyproheptadine inhibits tumor growth with extremely low toxicity to normal cells. Cyproheptadine can be used in research related to hepatocellular carcinoma, multiple myeloma and acute myeloid leukemia.
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- CAS. Nr.: 2712455-05-3
- Formel: C21H18D3N
- Molecular Weight:290.42
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
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H1 Receptor |
Chk2 |
CDK1 |
CDK2 |
CDK3 |
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 2712455-05-3
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Unlabeled CAS 129-03-3
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Molecular Weight 290.42
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Formel C21H18D3N
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SMILES
[2H]C([2H])([2H])N1CC/C(CC1)=C2C3=CC=CC=C3C=CC4=CC=CC=C/24
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Feng YM, et al. Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinase. BMC Cancer. 2015;15:134. Published 2015 Mar 17. [Content Brief]
[2]. Mao X, et al. Cyproheptadine displays preclinical activity in myeloma and leukemia. Blood. 2008;112(3):760-769. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cyproheptadine-d3 Related Classifications
HY-B1622S Related Classifications
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Keywords
- Cyproheptadine-d3
- 2712455-05-3
- Isotope-Labeled Compounds
- p38 MAPK
- Checkpoint Kinase (Chk)
- Histamine Receptor
- 5-HT Receptor
- CDK
- PARP
- Apoptosis
- CHK2
- histamine H1 receptor
- LP-1
- hepatocellular carcinoma
- acute myeloid leukemia
- human hematopoietic stem cells
- p38 MAP kinase
- serotonin receptor
- multiple myeloma
- MDAY-D2 cells
- Inhibitor
- inhibitor
- inhibit