Art. -Nr.: HY-128393

Trilinolein

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Trilinolein is an orally active triglyceride that inhibits the PI3K/Akt, Ras/MEK/ERK signaling pathways, and MMP-2. Trilinolein can reduce oxidative stress, induce apoptosis, and inhibit cell migration. Trilinolein can be used in the research fields of cardiovascular disease, cerebrovascular disease (such as cerebral ischemia), and non-small cell lung cancer.

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Reinheit: 98.0%
CAS. Nr.: 537-40-6
Formel: C₅₇H₉₈O₆
Molecular Weight:879.38

Speicherung:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Trilinolein Chemical Structure

CAS. Nr.: 537-40-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

MMP-2

Alle PI3K Isoform-spezifische Produkte anzeigen :

Alle ERK Isoform-spezifische Produkte anzeigen :

Alle MEK Isoform-spezifische Produkte anzeigen :

Alle Akt Isoform-spezifische Produkte anzeigen :

Alle MMP Isoform-spezifische Produkte anzeigen :

In Vitro

Trilinolein (10 μM; 24 h) can increase the cell viability of endothelial cells stimulated by ox-LDL (HY-NP135), reduce apoptosis, inhibit ICAM-1 and E-selectin mRNA expression, and enhance antioxidant activity (increased SOD and GPX, decreased MDA)^[1].
Trilinolein (3.12-100 μg/mL; 24-48 h) inhibits the viability of A549, A498 and MKN-45 cells, induces apoptosis and G₀/G₁ phase arrest in A549 cells, downregulates the PI3K/Akt pathway, and increases intracellular ROS^[2].
Trilinolein (5-20 μM; 24-72 h) inhibits PDGF-BB-stimulated A7r5 vascular smooth muscle cell migration and reduces the protein levels of Ras, MEK, p-MEK, p-ERK, and MMP-2^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]^[2]

Cell Line:

Endothelial cells; A549 cells
Concentration:

10 μmol/L (for endothelial cells); 25, 50, 75, 100 μg/mL (for A549 cells)
Incubation Time:

24 h (endothelial cells); 24-48 h (A549 cells)
Result:

Reduced apoptosis (19%) compared to ox-LDL group (23%) in endothelial cells.
In A549 cells, increased sub-G1 population in a dose- and time-dependent manner, with 20.32% apoptotic cells at 75 μg/mL for 48 h.

In Vivo

Trilinolein (50, 100, 200 mg/kg; oral; single dose; 1 hour before ischemia, 24 hours after reperfusion) can reduce cerebral infarction area, neurological deficits and TUNEL-positive neuronal apoptosis in the Sprague-Dawley rat model of cerebral ischemia-reperfusion^[3].
Trilinolein (100, 200 mg/kg; oral; once a day; 28 days) can reduce the intima/media ratio and PCNA-positive cells in the carotid artery ligation-induced intimal hyperplasia model of ICR mice, and reduce intimal hyperplasia^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male ICR mice (22-25 g) with carotid artery ligation-induced intimal hyperplasia model (ligation of left common carotid artery)^[3]
Dosage:

100, 200 mg/kg
Administration:

Oral administration (gastric gavage), once daily, 28 days (starting from the second day after ligation)
Result:

Significantly reduced the intima/media ratio and decreased the percentage of PCNA-positive cells, ameliorating intimal hyperplasia.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 537-40-6
Appearance Liquid (Density: 0.9184 g/cm³)
Molecular Weight 879.38
Formel C₅₇H₉₈O₆
Color Colorless to light yellow
SMILES

CCCCC/C=C\C/C=C\CCCCCCCC(OCC(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Journal Impact Factor

Toxicol Appl Pharmacol

The skin photoprotective effect of trilinolein: Induction of cellular autophagy via the AMPK-mTOR signaling pathway. [Abstract]

2024 Feb:483:116836. PMID: 38272316

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (113.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1372 mL

5.6858 mL

11.3716 mL

5 mM

0.2274 mL

1.1372 mL

2.2743 mL

10 mM

0.1137 mL

0.5686 mL

1.1372 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (2.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (2.84 mM); Suspended solution

This protocol yields a suspended solution of ≥ 2.5 mg/mL (saturation unknown). Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Luo T, et al. Triolein and trilinolein ameliorate oxidized low-density lipoprotein-induced oxidative stress in endothelial cells. Lipids. 2014 May;49(5):495-504. [Content Brief]

[2]. Chou PY, et al. Trilinolein inhibits proliferation of human non-small cell lung carcinoma A549 through the modulation of PI3K/Akt pathway. Am J Chin Med. 2011;39(4):803-15. [Content Brief]

[3]. Chen YF, et al. Trilinolein, a Natural Triacylglycerol, Protects Cerebral Ischemia through Inhibition of Neuronal Apoptosis and Ameliorates Intimal Hyperplasia via Attenuation of Migration and Modulation of Matrix Metalloproteinase-2 and RAS/MEK/ERK Signaling Pathway in VSMCs. Int J Mol Sci. 2022 Oct 24;23(21):12820. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.1372 mL	5.6858 mL	11.3716 mL	28.4291 mL
	5 mM	0.2274 mL	1.1372 mL	2.2743 mL	5.6858 mL
	10 mM	0.1137 mL	0.5686 mL	1.1372 mL	2.8429 mL
	15 mM	0.0758 mL	0.3791 mL	0.7581 mL	1.8953 mL
	20 mM	0.0569 mL	0.2843 mL	0.5686 mL	1.4215 mL
	25 mM	0.0455 mL	0.2274 mL	0.4549 mL	1.1372 mL
	30 mM	0.0379 mL	0.1895 mL	0.3791 mL	0.9476 mL
	40 mM	0.0284 mL	0.1421 mL	0.2843 mL	0.7107 mL
	50 mM	0.0227 mL	0.1137 mL	0.2274 mL	0.5686 mL
	60 mM	0.0190 mL	0.0948 mL	0.1895 mL	0.4738 mL
	80 mM	0.0142 mL	0.0711 mL	0.1421 mL	0.3554 mL
	100 mM	0.0114 mL	0.0569 mL	0.1137 mL	0.2843 mL

Keywords

Trilinolein

1 Cited Publications

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Trilinolein

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Publications Citing Use of MedChemExpress (MCE) Trilinolein

Alle PI3K Isoform-spezifische Produkte anzeigen

Alle ERK Isoform-spezifische Produkte anzeigen

Alle MEK Isoform-spezifische Produkte anzeigen

Alle Akt Isoform-spezifische Produkte anzeigen

Alle MMP Isoform-spezifische Produkte anzeigen

Biologische Aktivität