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Cat. No.: HY-155570

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Anticancer agent 137

Anticancer agent 137 (8q) is a potent PI3k inhibitor. Anticancer agent 137 has broad-spectrum anticancer activity. Anticancer agent 137 induces G2/M cell cycle arrest and apoptosis. Anticancer agent 137 increases cleaved PARP, caspase 3, and 7. Anticancer agent 137 can be used in research of cancer.

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Formule: C₂₆H₂₇NO₆
Masse moléculaire:449.50

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Anticancer agent 137 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform PI3K :

Voir tous les produits spécifiques à Isoform Caspase :

Voir tous les produits spécifiques à Isoform PARP :

Cellular Effect

Cell Line	Type	Value	Description	References
A498	GI₅₀	1.38 μM Compound: 8q	Growth inhibition of human A498 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human A498 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
ACHN	GI₅₀	4.27 μM Compound: 8q	Growth inhibition of human ACHN cells measured after 24 to 72 hrs by SRB method Growth inhibition of human ACHN cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
COLO 205	GI₅₀	2.4 μM Compound: 8q	Growth inhibition of human COLO 205 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human COLO 205 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
DU-145	GI₅₀	2.95 μM Compound: 8q	Growth inhibition of human DU-145 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human DU-145 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
IGROV-1	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human IGROV-1 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human IGROV-1 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
KM12	GI₅₀	3.47 μM Compound: 8q	Growth inhibition of human KM12 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human KM12 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
MDA-MB-435	GI₅₀	0.52 μM Compound: 8q	Growth inhibition of human MDA-MB-435 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human MDA-MB-435 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
NCI/ADR-RES	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human NCI-ADR-RES cells measured after 24 to 72 hrs by SRB method Growth inhibition of human NCI-ADR-RES cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
OVCAR-3	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human OVCAR-3 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human OVCAR-3 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
OVCAR-4	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human OVCAR-4 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human OVCAR-4 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
OVCAR-5	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human OVCAR-5 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human OVCAR-5 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
OVCAR-8	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human OVCAR-8 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human OVCAR-8 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
PC-3	GI₅₀	1.58 μM Compound: 8q	Growth inhibition of human PC-3 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human PC-3 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
SF-268	GI₅₀	5.13 μM Compound: 8q	Growth inhibition of human SF-268 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human SF-268 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
SF-295	GI₅₀	2.51 μM Compound: 8q	Growth inhibition of human SF-295 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human SF-295 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
SK-MEL-28	GI₅₀	4.07 μM Compound: 8q	Growth inhibition of human SK-MEL-28 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human SK-MEL-28 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
SK-OV-3	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human SK-OV-3 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human SK-OV-3 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]

Chemical Information

Masse moléculaire 449.50
Formule C₂₆H₂₇NO₆
SMILES

COC1=C(C(OC)=CC2=C1CCC(O2)C3=CC=CC(C(NC4=CC=C(C=C4)OC)=O)=C3)OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hassan AHE, et, al. Scaffold hopping of N-benzyl-3,4,5-trimethoxyaniline: 5,6,7-Trimethoxyflavan derivatives as novel potential anticancer agents modulating hippo signaling pathway. Eur J Med Chem. 2023 Aug 5;256:115421. [Content Brief]

Calculators

Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Références

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Anticancer agent 137

Voir tous les produits spécifiques à Isoform PI3K

Voir tous les produits spécifiques à Isoform Caspase

Voir tous les produits spécifiques à Isoform PARP

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Anticancer agent 137 Related Classifications

HY-155570 Related Classifications