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Cat. No.: HY-155570

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Anticancer agent 137

Anticancer agent 137 (8q) is a potent PI3k inhibitor. Anticancer agent 137 has broad-spectrum anticancer activity. Anticancer agent 137 induces G2/M cell cycle arrest and apoptosis. Anticancer agent 137 increases cleaved PARP, caspase 3, and 7. Anticancer agent 137 can be used in research of cancer.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₇NO₆
Molecular Weight:449.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Anticancer agent 137 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PI3K Isoforms :

All Caspase Isoforms :

All PARP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A498	GI₅₀	1.38 μM Compound: 8q	Growth inhibition of human A498 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human A498 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
ACHN	GI₅₀	4.27 μM Compound: 8q	Growth inhibition of human ACHN cells measured after 24 to 72 hrs by SRB method Growth inhibition of human ACHN cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
COLO 205	GI₅₀	2.4 μM Compound: 8q	Growth inhibition of human COLO 205 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human COLO 205 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
DU-145	GI₅₀	2.95 μM Compound: 8q	Growth inhibition of human DU-145 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human DU-145 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
IGROV-1	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human IGROV-1 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human IGROV-1 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
KM12	GI₅₀	3.47 μM Compound: 8q	Growth inhibition of human KM12 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human KM12 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
MDA-MB-435	GI₅₀	0.52 μM Compound: 8q	Growth inhibition of human MDA-MB-435 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human MDA-MB-435 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
NCI/ADR-RES	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human NCI-ADR-RES cells measured after 24 to 72 hrs by SRB method Growth inhibition of human NCI-ADR-RES cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
OVCAR-3	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human OVCAR-3 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human OVCAR-3 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
OVCAR-4	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human OVCAR-4 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human OVCAR-4 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
OVCAR-5	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human OVCAR-5 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human OVCAR-5 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
OVCAR-8	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human OVCAR-8 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human OVCAR-8 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
PC-3	GI₅₀	1.58 μM Compound: 8q	Growth inhibition of human PC-3 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human PC-3 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
SF-268	GI₅₀	5.13 μM Compound: 8q	Growth inhibition of human SF-268 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human SF-268 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
SF-295	GI₅₀	2.51 μM Compound: 8q	Growth inhibition of human SF-295 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human SF-295 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
SK-MEL-28	GI₅₀	4.07 μM Compound: 8q	Growth inhibition of human SK-MEL-28 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human SK-MEL-28 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
SK-OV-3	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human SK-OV-3 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human SK-OV-3 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]

Chemical Information

Molecular Weight 449.50
Formula C₂₆H₂₇NO₆
SMILES

COC1=C(C(OC)=CC2=C1CCC(O2)C3=CC=CC(C(NC4=CC=C(C=C4)OC)=O)=C3)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hassan AHE, et, al. Scaffold hopping of N-benzyl-3,4,5-trimethoxyaniline: 5,6,7-Trimethoxyflavan derivatives as novel potential anticancer agents modulating hippo signaling pathway. Eur J Med Chem. 2023 Aug 5;256:115421. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Anticancer agent 137

All PI3K Isoforms

All Caspase Isoforms

All PARP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Anticancer agent 137 Related Classifications

HY-155570 Related Classifications