Dhfr - dihydrofolate reductase Gene
Also Known as 8430436I03Rik
Species: Mus musculus
Gene Type: protein coding
Gene ID: 13361
About Dhfr
Chromosome 13: 92,491,234-92,525,561 forward strand.GRCm39:CM001006.3
This gene has 1 transcript (splice variant), 356 orthologues, 1 paralogue and is associated with 30 phenotypes. Broad expression in liver E14 (RPKM 9.4), liver E14.5 (RPKM 7.) and 22 other tissues.
Summary
Enables dihydrofolate reductase activity. Involved in several processes, including positive regulation of nitric-oxide synthase activity; tetrahydrobiopterin biosynthetic process; and tetrahydrofolate interconversion. Located in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including DHFRP1 (dihydrofolate reductase pseudogene 1). [provided by Alliance of Genome Resources, Apr 2022]
Dhfr Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_010049.3 | NP_034179.1 | dihydrofolate reductase |
Dhfr Protein Structure
DHFR
DHFR: cd00209 (4 - 183)
- 0
- 100
- 187 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
dihydrofolate reductase |
|
Related Agents
- Approval
- Clinical Phase
- Pre-clinical Phase
Approval
Bioactive Molecules
(13)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-10820 | Pemetrexed | Inducer | 99.97% | Unkown |
| HY-10446 | Pralatrexate | Inducer | 99.23% | Yes |
| HY-10820A | Pemetrexed disodium | Inducer | 99.79% | Unkown |
| HY-18062 | Pyrimethamine | 99.99% | Yes | |
| HY-10373 | Trimetrexate | Inhibitor | 99.60% | Unkown |
| HY-B0806 | Proguanil | Inhibitor | 99.84% | Unkown |
| HY-13781 | Pemetrexed disodium hemipenta hydrate | Inducer | 99.78% | Unkown |
| HY-10820B | Pemetrexed disodium heptahydrate | 99.97% | Unkown | |
| HY-I0447 | 4-Aminosalicylic acid | Inhibitor | 99.82% | Yes |
| HY-I0447A | Sodium 4-aminosalicylate dihydrate | Inhibitor | 99.95% | Yes |
| HY-B0806A | Proguanil hydrochloride | Inhibitor | 99.21% | Unkown |
| HY-10373A | Trimetrexate trihydrochloride | Inhibitor | / | Unkown |
| HY-10373B | Trimetrexate isethionate | Inhibitor | / | Unkown |
Clinical Phase
Bioactive Molecules
(5)
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-14518 | Aminopterin | Antagonist | 99.33% | Phase 2 |
| HY-106434 | Piritrexim | Inhibitor | 99.07% | Phase 2 |
| HY-10824A | Talotrexin monoammonium | Inhibitor | / | Phase 2 |
| HY-19095 | TNP-351 | / | Phase 2 | |
| HY-19885 | AR-102 | Inhibitor | / | Phase 2 |
Pre-clinical Phase
Bioactive Molecules
(106)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-116387 | WR99210 | Inhibitor | 99.10% | Unkown |
| HY-12784A | Cycloguanil hydrochloride | Inhibitor | 99.93% | Unkown |
| HY-N0913 | Manninotriose | Modulator | 99.97% | Unkown |
| HY-10824 | Talotrexin | 99.27% | Unkown | |
| HY-W587663 | 4′-DTMP | Inhibitor | 97.33% | Unkown |
| HY-116387A | WR99210 hydrochloride | Inhibitor | 98.34% | Unkown |
| HY-107033 | Tetroxoprim | Inhibitor | 98.97% | Unkown |
| HY-162475 | Fluorofolin | Inhibitor | 99.85% | Unkown |
| HY-W003561 | DHFR-IN-3 | Inhibitor | 99.48% | Unkown |
| HY-126316 | Zapalog | Modulator | 99.62% | Unkown |
| HY-RS03730 | DHFR Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-18062S | Pyrimethamine-d3 | 99.90% | Unkown | |
| HY-139743 | Aditoprime | Inhibitor | 99.68% | Unkown |
| HY-151159 | DHFR-IN-4 | Inhibitor | 99.19% | Unkown |
| HY-B1902 | Diaveridine | 99.69% | Unkown | |
| HY-137129 | 10-Formyl-7,8-dihydrofolic acid | Substrate | 97.70% | Unkown |
| HY-153007 | DHFR-IN-5 | Inhibitor | 99.27% | Unkown |
| HY-169790 | Phomarin | Inhibitor | 98.53% | Unkown |
| HY-137439 | Fanotaprim | 98.89% | Unkown | |
| HY-12784 | Cycloguanil | Inhibitor | / | Unkown |
| HY-12784S | Cycloguanil-d6 | Inhibitor | 98.0% | Unkown |
| HY-176557 | NCI677397 | / | Unkown | |
| HY-B0806AS1 | Proguanil-d6 hydrochloride | Inhibitor | 98.73% | Unkown |
| HY-22252 | 4-Aminosalicylic acid hemicalcium | Inhibitor | / | Unkown |
| HY-12784AS | Cycloguanil-d4 hydrochloride | Inhibitor | / | Unkown |
| HY-10446S1 | Pralatrexate-13C5,15N | Inducer | / | Unkown |
| HY-10820AS | Pemetrexed-d5 disodium | Inducer | / | Unkown |
| HY-10820S | Pemetrexed-d5 | / | Unkown | |
| HY-10824B | Talotrexin ammonium | Inhibitor | / | Unkown |
| HY-116039 | Epiroprim | Inhibitor | / | Unkown |
| HY-117000 | D156844 | Agonist | / | Unkown |
| HY-117000A | D156844 hydrochloride | Agonist | / | Unkown |
| HY-117791 | (R)-Pralatrexate | Control | / | Unkown |
| HY-121207 | Denopterin | Inhibitor | / | Unkown |
| HY-122045 | CB 3705 | Inhibitor | / | Unkown |
| HY-122289 | Metioprim | Inhibitor | / | Unkown |
| HY-12784AR | Cycloguanil hydrochloride (Standard) | Inhibitor | / | Unkown |
| HY-12784AS1 | Cycloguanil-d6 hydrochloride | Inhibitor | / | Unkown |
| HY-12784S1 | Cycloguanil-d6 nitrate | Inhibitor | / | Unkown |
| HY-137357 | 5-Monobutyl methotrexate | Inhibitor | / | Unkown |
| HY-143236 | DHFR-IN-1 | Inhibitor | / | Unkown |
| HY-147661 | DHFR-IN-2 | Inhibitor | / | Unkown |
| HY-149200 | Lysine-methotrexate | / | Unkown | |
| HY-149632 | EGFR/HER2/DHFR-IN-2 | Inhibitor | / | Unkown |
| HY-149633 | EGFR/HER2/DHFR-IN-3 | / | Unkown | |
| HY-149958 | Antileishmanial agent-17 | Inhibitor | / | Unkown |
| HY-151154 | EGFR/HER2/DHFR-IN-1 | Inhibitor | / | Unkown |
| HY-151156 | EGFR/HER2-IN-6 | / | Unkown | |
| HY-151158 | EGFR/HER2-IN-7 | Inhibitor | / | Unkown |
| HY-151161 | EGFR/HER2-IN-8 | Inhibitor | / | Unkown |
| HY-151458 | VEGFR-2/DHFR-IN-1 | Inhibitor | / | Unkown |
| HY-151459 | VEGFR-2/DHFR-IN-2 | Inhibitor | / | Unkown |
| HY-154807 | DQn-1 | Inhibitor | / | Unkown |
| HY-156122 | DHFR-IN-8 | Inhibitor | / | Unkown |
| HY-156123 | DHFR-IN-9 | Inhibitor | / | Unkown |
| HY-156859 | NSC309401 dihydrochloride | Inhibitor | / | Unkown |
| HY-160254 | 1954U89 | Inhibitor | / | Unkown |
| HY-162358 | DHFR-IN-17 | Inhibitor | / | Unkown |
| HY-163722 | EGFR/DHFR-IN-1 | Inhibitor | / | Unkown |
| HY-168648 | DNA Gyrase/DHFR-IN-1 | Inhibitor | / | Unkown |
| HY-168918 | Insecticidal agent 19 | Inhibitor | / | Unkown |
| HY-172897 | EGFR/DHFR-IN-2 | / | Unkown | |
| HY-173220 | DHFR-IN-23 | / | Unkown | |
| HY-178728 | BION106 | / | Unkown | |
| HY-178759 | DHFR-IN-5-amino-PEG3-C2-azido | / | Unkown | |
| HY-183053 | UCP1173 | Inhibitor | / | Unkown |
| HY-183286 | DHFR-IN-27 | Inhibitor | / | Unkown |
| HY-185443 | UCP1172 | Inhibitor | / | Unkown |
| HY-B0806S1 | Proguanil-d4 | / | Unkown | |
| HY-B1902S | Diaveridine-d6 | / | Unkown | |
| HY-E70522 | Dihydrofolate reductase | / | Unkown | |
| HY-I0447S | 4-Aminosalicylic acid-d6 | / | Unkown | |
| HY-N10791 | Neobritannilactone B | / | Unkown | |
| HY-RS03731 | Dhfr Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS03732 | Dhfr Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-W769288 | Pemetrexed disodium-13C5 | / | Unkown | |
| HY-Z15986 | Methotrexate diethyl ester | Inhibitor | / | Unkown |
| HY-105714 | Etoprine | Inhibitor | / | Unkown |
| HY-115836 | DDPO | Inhibitor | / | Unkown |
| HY-118251 | PD130883 | Inhibitor | / | Unkown |
| HY-119613 | Clociguanil | Inhibitor | / | Unkown |
| HY-143408 | OYYF-175 | Inhibitor | / | Unkown |
| HY-149699 | DHFR-IN-12 | Inhibitor | / | Unkown |
| HY-153007A | DHFR-IN-5 hydrochloride | Inhibitor | / | Unkown |
| HY-156412 | DHFR-IN-10 | Inhibitor | / | Unkown |
| HY-156414 | DHFR-IN-11 | Inhibitor | / | Unkown |
| HY-156859A | NSC309401 | Inhibitor | / | Unkown |
| HY-159899 | DHFR-IN-22 | Inhibitor | / | Unkown |
| HY-161010 | DHFR-IN-13 | Inhibitor | / | Unkown |
| HY-161063 | DHFR-IN-14 | Inhibitor | / | Unkown |
| HY-161064 | DHFR-IN-15 | Inhibitor | / | Unkown |
| HY-161292 | DHFR-IN-16 | Inhibitor | / | Unkown |
| HY-162656 | DHFR-IN-19 | Inhibitor | / | Unkown |
| HY-163725 | DHFR-IN-18 | Inhibitor | / | Unkown |
| HY-168069 | DHFR-IN-20 | Inhibitor | / | Unkown |
| HY-169211 | DHFR-IN-21 | / | Unkown | |
| HY-177337 | N-Didesmethyladitoprim | Inhibitor | / | Unkown |
| HY-179415 | DHFR-IN-24 | Inhibitor | / | Unkown |
| HY-179493 | DHFR-IN-25 | Inhibitor | / | Unkown |
| HY-181100 | DHFR-IN-26 | Inhibitor | / | Unkown |
| HY-181813 | PROTAC DHFR Degrader-1 | / | Unkown | |
| HY-181814 | DHFR ligand-Linker Conjugate 1 | / | Unkown | |
| HY-182684 | MMV675968 | Inhibitor | / | Unkown |
| HY-B0806AS | Proguanil-d4 hydrochloride | Inhibitor | / | Unkown |
| HY-N3764 | Diosbulbin C | Activator | / | Unkown |
| HY-W167448 | DHFR-IN-28 | Inhibitor | / | Unkown |
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