Dhfr - dihydrofolate reductase Gene

Also Known as Dhfr1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24312

About Dhfr

Primary_assembly 2: 23,586,031-23,613,713 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 356 orthologues, 1 paralogue and is associated with 25 phenotypes. Biased expression in Kidney (RPKM 45.8), Liver (RPKM 427.1) and 5 other tissues.

Summary

Enables NADP binding activity; dihydrofolate reductase activity; and dihydrofolic acid binding activity. Involved in several processes, including axon regeneration; folic acid-containing compound metabolic process; and response to methotrexate. Located in mitochondrion. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including DHFR2 (dihydrofolate reductase 2) and DHFRP1 (dihydrofolate reductase pseudogene 1). [provided by Alliance of Genome Resources, Apr 2022]

Dhfr Products (1)

mRNA Protein Name
NM_130400.2 NP_569084.1 dihydrofolate reductase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NADP binding IDA
IDA: Inferred from direct assay
3970530 RGD
enables dihydrofolate reductase activity IDA
IDA: Inferred from direct assay
3970530 RGD
enables dihydrofolate reductase activity IMP
IMP: Inferred from mutant phenotype
6162551 RGD
enables dihydrofolic acid binding IDA
IDA: Inferred from direct assay
3970530 RGD
Biological Process GO Annotation Evidence References Source
involved in axon regeneration IMP
IMP: Inferred from mutant phenotype
20424322 RGD
involved in dihydrofolate metabolic process IDA
IDA: Inferred from direct assay
3970530 RGD
involved in folic acid metabolic process IDA
IDA: Inferred from direct assay
20424322 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
15983034 RGD
involved in tetrahydrofolate biosynthetic process IDA
IDA: Inferred from direct assay
11502523 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25980602 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
25980602 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dhfr Protein Structure

DHFR

DHFR: cd00209 (4 - 183)

  • 0
  • 100
  • 187 a.a.
Protein Preferred Names Protein Names

dihydrofolate reductase

  • Dihydrofolate reductase 1 (active)

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (13)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-10820 Pemetrexed Inducer 99.97% Unkown
HY-10446 Pralatrexate Inducer 99.23% Yes
HY-10820A Pemetrexed disodium Inducer 99.94% Unkown
HY-18062 Pyrimethamine 99.99% Yes
HY-10373 Trimetrexate Inhibitor 99.60% Unkown
HY-B0806 Proguanil Inhibitor 99.84% Unkown
HY-13781 Pemetrexed disodium hemipenta hydrate Inducer 99.78% Unkown
HY-10820B Pemetrexed disodium heptahydrate 99.97% Unkown
HY-I0447 4-Aminosalicylic acid Inhibitor 99.82% Yes
HY-I0447A Sodium 4-aminosalicylate dihydrate Inhibitor 99.95% Yes
HY-B0806A Proguanil hydrochloride Inhibitor 99.21% Unkown
HY-10373A Trimetrexate trihydrochloride Inhibitor / Unkown
HY-10373B Trimetrexate isethionate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. 상품명 효과
Purity Phase
HY-14518 Aminopterin Antagonist 99.33% Phase 2
HY-106434 Piritrexim Inhibitor 99.07% Phase 2
HY-10824A Talotrexin monoammonium Inhibitor / Phase 2
HY-19095 TNP-351 / Phase 2
HY-19885 AR-102 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (107)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-116387 WR99210 Inhibitor 99.10% Unkown
HY-12784A Cycloguanil hydrochloride Inhibitor 99.93% Unkown
HY-N0913 Manninotriose Modulator 99.97% Unkown
HY-10824 Talotrexin 99.27% Unkown
HY-W587663 4′-DTMP Inhibitor 97.33% Unkown
HY-116387A WR99210 hydrochloride Inhibitor 98.34% Unkown
HY-107033 Tetroxoprim Inhibitor 98.97% Unkown
HY-162475 Fluorofolin Inhibitor 99.85% Unkown
HY-W003561 DHFR-IN-3 Inhibitor 99.48% Unkown
HY-126316 Zapalog Modulator 99.62% Unkown
HY-RS03730 DHFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-18062S Pyrimethamine-d3 99.90% Unkown
HY-139743 Aditoprime Inhibitor 99.68% Unkown
HY-151159 DHFR-IN-4 Inhibitor 99.19% Unkown
HY-B1902 Diaveridine 99.69% Unkown
HY-137129 10-Formyl-7,8-dihydrofolic acid Substrate 97.70% Unkown
HY-153007 DHFR-IN-5 Inhibitor 99.27% Unkown
HY-169790 Phomarin Inhibitor 98.53% Unkown
HY-137439 Fanotaprim 98.07% Unkown
HY-12784 Cycloguanil Inhibitor / Unkown
HY-12784S Cycloguanil-d6 Inhibitor 98.0% Unkown
HY-176557 NCI677397 / Unkown
HY-B0806AS1 Proguanil-d6 hydrochloride Inhibitor 98.73% Unkown
HY-22252 4-Aminosalicylic acid hemicalcium Inhibitor / Unkown
HY-12784AS Cycloguanil-d4 hydrochloride Inhibitor / Unkown
HY-10446S1 Pralatrexate-13C5,15N Inducer / Unkown
HY-10820AS Pemetrexed-d5 disodium Inducer / Unkown
HY-10820S Pemetrexed-d5 / Unkown
HY-10824B Talotrexin ammonium Inhibitor / Unkown
HY-116039 Epiroprim Inhibitor / Unkown
HY-117000 D156844 Agonist / Unkown
HY-117000A D156844 hydrochloride Agonist / Unkown
HY-117791 (R)-Pralatrexate Control / Unkown
HY-121207 Denopterin Inhibitor / Unkown
HY-122045 CB 3705 Inhibitor / Unkown
HY-122289 Metioprim Inhibitor / Unkown
HY-12784AR Cycloguanil hydrochloride (Standard) Inhibitor / Unkown
HY-12784AS1 Cycloguanil-d6 hydrochloride Inhibitor / Unkown
HY-12784S1 Cycloguanil-d6 nitrate Inhibitor / Unkown
HY-137357 5-Monobutyl methotrexate Inhibitor / Unkown
HY-143236 DHFR-IN-1 Inhibitor / Unkown
HY-147661 DHFR-IN-2 Inhibitor / Unkown
HY-149200 Lysine-methotrexate / Unkown
HY-149632 EGFR/HER2/DHFR-IN-2 Inhibitor / Unkown
HY-149633 EGFR/HER2/DHFR-IN-3 / Unkown
HY-149958 Antileishmanial agent-17 Inhibitor / Unkown
HY-151154 EGFR/HER2/DHFR-IN-1 Inhibitor / Unkown
HY-151156 EGFR/HER2-IN-6 / Unkown
HY-151158 EGFR/HER2-IN-7 Inhibitor / Unkown
HY-151161 EGFR/HER2-IN-8 Inhibitor / Unkown
HY-151458 VEGFR-2/DHFR-IN-1 Inhibitor / Unkown
HY-151459 VEGFR-2/DHFR-IN-2 Inhibitor / Unkown
HY-154807 DQn-1 Inhibitor / Unkown
HY-156122 DHFR-IN-8 Inhibitor / Unkown
HY-156123 DHFR-IN-9 Inhibitor / Unkown
HY-156859 NSC309401 dihydrochloride Inhibitor / Unkown
HY-160254 1954U89 Inhibitor / Unkown
HY-162358 DHFR-IN-17 Inhibitor / Unkown
HY-163722 EGFR/DHFR-IN-1 Inhibitor / Unkown
HY-168648 DNA Gyrase/DHFR-IN-1 Inhibitor / Unkown
HY-168918 Insecticidal agent 19 Inhibitor / Unkown
HY-172897 EGFR/DHFR-IN-2 / Unkown
HY-173220 DHFR-IN-23 / Unkown
HY-178728 BION106 / Unkown
HY-178759 DHFR-IN-5-amino-PEG3-C2-azido / Unkown
HY-183053 UCP1173 Inhibitor / Unkown
HY-183286 DHFR-IN-27 Inhibitor / Unkown
HY-185443 UCP1172 Inhibitor / Unkown
HY-187213 Anti-MRSA agent 45 / Unkown
HY-B0806S1 Proguanil-d4 / Unkown
HY-B1902S Diaveridine-d6 / Unkown
HY-E70522 Dihydrofolate reductase / Unkown
HY-I0447S 4-Aminosalicylic acid-d6 / Unkown
HY-N10791 Neobritannilactone B / Unkown
HY-RS03731 Dhfr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03732 Dhfr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W769288 Pemetrexed disodium-13C5 / Unkown
HY-Z15986 Methotrexate diethyl ester Inhibitor / Unkown
HY-105714 Etoprine Inhibitor / Unkown
HY-115836 DDPO Inhibitor / Unkown
HY-118251 PD130883 Inhibitor / Unkown
HY-119613 Clociguanil Inhibitor / Unkown
HY-143408 OYYF-175 Inhibitor / Unkown
HY-149699 DHFR-IN-12 Inhibitor / Unkown
HY-153007A DHFR-IN-5 hydrochloride Inhibitor / Unkown
HY-156412 DHFR-IN-10 Inhibitor / Unkown
HY-156414 DHFR-IN-11 Inhibitor / Unkown
HY-156859A NSC309401 Inhibitor / Unkown
HY-159899 DHFR-IN-22 Inhibitor / Unkown
HY-161010 DHFR-IN-13 Inhibitor / Unkown
HY-161063 DHFR-IN-14 Inhibitor / Unkown
HY-161064 DHFR-IN-15 Inhibitor / Unkown
HY-161292 DHFR-IN-16 Inhibitor / Unkown
HY-162656 DHFR-IN-19 Inhibitor / Unkown
HY-163725 DHFR-IN-18 Inhibitor / Unkown
HY-168069 DHFR-IN-20 Inhibitor / Unkown
HY-169211 DHFR-IN-21 / Unkown
HY-177337 N-Didesmethyladitoprim Inhibitor / Unkown
HY-179415 DHFR-IN-24 Inhibitor / Unkown
HY-179493 DHFR-IN-25 Inhibitor / Unkown
HY-181100 DHFR-IN-26 Inhibitor / Unkown
HY-181813 PROTAC DHFR Degrader-1 / Unkown
HY-181814 DHFR ligand-Linker Conjugate 1 / Unkown
HY-182684 MMV675968 Inhibitor / Unkown
HY-B0806AS Proguanil-d4 hydrochloride Inhibitor / Unkown
HY-N3764 Diosbulbin C Activator / Unkown
HY-W167448 DHFR-IN-28 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dhfr NCBI NCBI:1719