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製品番号: HY-155570

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Anticancer agent 137

Anticancer agent 137 (8q) is a potent PI3k inhibitor. Anticancer agent 137 has broad-spectrum anticancer activity. Anticancer agent 137 induces G2/M cell cycle arrest and apoptosis. Anticancer agent 137 increases cleaved PARP, caspase 3, and 7. Anticancer agent 137 can be used in research of cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₆H₂₇NO₆
分子量:449.50

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Anticancer agent 137 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PI3K アイソフォーム固有の製品をすべて表示 :

Caspase アイソフォーム固有の製品をすべて表示 :

PARP アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A498	GI₅₀	1.38 μM Compound: 8q	Growth inhibition of human A498 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human A498 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
ACHN	GI₅₀	4.27 μM Compound: 8q	Growth inhibition of human ACHN cells measured after 24 to 72 hrs by SRB method Growth inhibition of human ACHN cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
COLO 205	GI₅₀	2.4 μM Compound: 8q	Growth inhibition of human COLO 205 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human COLO 205 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
DU-145	GI₅₀	2.95 μM Compound: 8q	Growth inhibition of human DU-145 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human DU-145 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
IGROV-1	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human IGROV-1 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human IGROV-1 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
KM12	GI₅₀	3.47 μM Compound: 8q	Growth inhibition of human KM12 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human KM12 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
MDA-MB-435	GI₅₀	0.52 μM Compound: 8q	Growth inhibition of human MDA-MB-435 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human MDA-MB-435 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
NCI/ADR-RES	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human NCI-ADR-RES cells measured after 24 to 72 hrs by SRB method Growth inhibition of human NCI-ADR-RES cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
OVCAR-3	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human OVCAR-3 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human OVCAR-3 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
OVCAR-4	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human OVCAR-4 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human OVCAR-4 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
OVCAR-5	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human OVCAR-5 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human OVCAR-5 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
OVCAR-8	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human OVCAR-8 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human OVCAR-8 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
PC-3	GI₅₀	1.58 μM Compound: 8q	Growth inhibition of human PC-3 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human PC-3 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
SF-268	GI₅₀	5.13 μM Compound: 8q	Growth inhibition of human SF-268 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human SF-268 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
SF-295	GI₅₀	2.51 μM Compound: 8q	Growth inhibition of human SF-295 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human SF-295 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
SK-MEL-28	GI₅₀	4.07 μM Compound: 8q	Growth inhibition of human SK-MEL-28 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human SK-MEL-28 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]
SK-OV-3	GI₅₀	2.82 μM Compound: 8q	Growth inhibition of human SK-OV-3 cells measured after 24 to 72 hrs by SRB method Growth inhibition of human SK-OV-3 cells measured after 24 to 72 hrs by SRB method	[PMID: 37163949]

化学情報

分子量 449.50
分子式 C₂₆H₂₇NO₆
SMILES

COC1=C(C(OC)=CC2=C1CCC(O2)C3=CC=CC(C(NC4=CC=C(C=C4)OC)=O)=C3)OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Hassan AHE, et, al. Scaffold hopping of N-benzyl-3,4,5-trimethoxyaniline: 5,6,7-Trimethoxyflavan derivatives as novel potential anticancer agents modulating hippo signaling pathway. Eur J Med Chem. 2023 Aug 5;256:115421. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
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化学情報
純度とドキュメンテーション
参考文献

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Anticancer agent 137

PI3K アイソフォーム固有の製品をすべて表示

Caspase アイソフォーム固有の製品をすべて表示

PARP アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Anticancer agent 137 関連分類

HY-155570 関連分類