Ceramide (Egg)
Based on 1 Customer Validation
Ceramide (Egg) (Ceramide (Egg, Chicken)) is a ceramide from chicken. Ceramide (Egg) is a sphingomyelin signaling pathway second messenger. Ceramide (Egg) activates PP2A, JNK, p38 MAPK, CAPK, ceramide-activated protein phosphatase, Vav, PKCζ, and SAPK/JNK cascade. Ceramide (Egg) downregulates or inhibits AKT, survivin, CDK2, mTOR, and FLIP. Ceramide (Egg) mediates apoptosis, autophagy, cell cycle arrest, mitochondrial dysfunction, redox state shifts, and ROS generation. Ceramide (Egg) can be used for the research of cancer and neurological disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99%
- CAS 番号: 477243-06-4
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Ceramide (Egg) induces apoptosis in human leukemia HL-60 cells via p38 MAPK activation, AKT inhibition, and BAX translocation to mitochondria[1].
Ceramide (Egg) induces apoptosis and G1 cell cycle arrest in human prostate cancer PC-3 cells via PP2A-dependent AKT dephosphorylation, and promotes cytochrome c release and caspase 9 activation via protein kinase Cδ activation[1].
Ceramide (Egg) induces autophagy in human nasopharyngeal carcinoma cells via JNK-dependent upregulation of LC3 expression[1].
Ceramide (Egg) induces autophagic cell death in human malignant glioma cells via BNIP3 activation, LC3 upregulation, and disruption of beclin 1-BCL-2 complexes[1].
Ceramide (Egg) induces G1 cell cycle arrest in human hepatocarcinoma cells via PPARγ activation, p21 upregulation, reduced CDK2/CDK7 activity, and hypophosphorylation of RB (in RB1+/+ cells)[1].
Ceramide (Egg) induces p21-dependent G2 cell cycle arrest in human rhabdomyosarcoma cells, which is attenuated by MDM2 overexpression[1].
Ceramide (Egg) induces apoptosis in human breast cancer cells, and this cytotoxicity is enhanced by Tamoxifen (HY-13757A) pretreatment, leading to increased cell cycle arrest, caspase activation, and mitochondrial outer membrane permeabilization[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ceramide (Egg) (endogenously generated via acid sphingomyelinase) is required for radiation-induced apoptosis in select mouse tissues including the lung, endocardium, pleura, and pericardium[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 477243-06-4
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性状 Solid
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Color White to off-white
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SMILES
[Ceramide (Egg)]
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別名
Ceramide (Egg, Chicken)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Morad SA, et al. Ceramide-orchestrated signalling in cancer cells. Nat Rev Cancer. 2013;13(1):51-65. [Content Brief]
[2]. Haimovitz-Friedman A, et al. Ceramide signaling in apoptosis. Br Med Bull. 1997;53(3):539-553. [Content Brief]
[3]. Ross MM, et al. Ceramide: a novel inducer for neural tube defects. Dev Dyn. 2019;248(10):979-996. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Ceramide (Egg) 関連分類
HY-125953 関連分類
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