Jak1 - Janus kinase 1 Gene

Also Known as BAP004; C130039L05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16451

About Jak1

Chromosome 4: 101,009,564-101,122,479 reverse strand.GRCm39:CM000997.3

This gene has 8 transcripts (splice variants), 238 orthologues, 32 paralogues and is associated with 66 phenotypes. Ubiquitous expression in thymus adult (RPKM 28.5), spleen adult (RPKM 26.3) and 28 other tissues.

Summary

Enables growth hormone receptor binding activity and protein tyrosine kinase activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to cytokine stimulus; and positive regulation of receptor signaling pathway via STAT. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; colorectal cancer; hepatocellular carcinoma; ovarian cancer; and pancreatic adenocarcinoma. Orthologous to human JAK1 (Janus kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Jak1 Products (2)

mRNA Protein Name
NM_146145.2 NP_666257.2 tyrosine-protein kinase JAK1 isoform 1
NM_013567.1 NP_038595.1 tyrosine-protein kinase JAK1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables growth hormone receptor binding IPI
IPI: Inferred from physical interaction
10502458 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12738762 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
10872802 MGI
enables protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
27671227 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to interleukin-3 IDA
IDA: Inferred from direct assay
8378315 MGI
acts upstream of or within cellular response to interleukin-7 IDA
IDA: Inferred from direct assay
29581031 MGI
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
8022486 MGI
acts upstream of or within enzyme-linked receptor protein signaling pathway IDA
IDA: Inferred from direct assay
8022486 MGI
acts upstream of or within intracellular signal transduction IDA
IDA: Inferred from direct assay
8022486 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10872802 MGI
acts upstream of or within positive regulation of receptor signaling pathway via STAT IMP
IMP: Inferred from mutant phenotype
27671227 MGI
acts upstream of or within tyrosine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
27671227 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Jak1 Protein Structure

FERM_F1

FERM_F1: cl39717 (51 - 128)

FERM_F2

FERM_F2: pfam18377 (146 - 276)

FERM_C_JAK1

FERM_C_JAK1: cd13332 (281 - 425)

SH2_Jak1

SH2_Jak1: cd10378 (425 - 525)

PTK_Jak1_rpt1

PTK_Jak1_rpt1: cd05077 (581 - 844)

PTKc_Jak1_rpt2

PTKc_Jak1_rpt2: cd05079 (868 - 1151)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1153 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase JAK1

  • JAK-1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (23)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50856 Ruxolitinib Inhibitor 99.99% Yes
HY-40354 Tofacitinib Inhibitor 99.99% Yes
HY-19569 Upadacitinib Inhibitor 99.98% Yes
HY-15315 Baricitinib Inhibitor 99.97% Yes
HY-117287 Deucravacitinib Inhibitor 99.93% Unkown
HY-50858 Ruxolitinib phosphate Inhibitor 99.92% Yes
HY-40354A Tofacitinib citrate Inhibitor 99.94% Yes
HY-16379 Pacritinib Inhibitor 99.93% Yes
HY-10961 Momelotinib Inhibitor 98.93% Unkown
HY-107429 Abrocitinib Inhibitor 99.26% Unkown
HY-18300 Filgotinib Inhibitor 99.77% Yes
HY-19568 Peficitinib Inhibitor 99.43% Yes
HY-15315A Baricitinib phosphate Inhibitor 99.97% Yes
HY-109053 Delgocitinib Inhibitor 99.61% Unkown
HY-13577 Oclacitinib Inhibitor 99.03% Unkown
HY-13577A Oclacitinib monomaleate Inhibitor 99.87% Unkown
HY-50856S Deuruxolitinib Inhibitor 99.18% Unkown
HY-18300A Filgotinib maleate Inhibitor 99.88% Yes
HY-50859 Ruxolitinib sulfate Inhibitor / Unkown
HY-19569A Upadacitinib tartrate tetrahydrate Inhibitor / Unkown
HY-19568A Peficitinib hydrobromide Inhibitor / Unkown
HY-16379A Pacritinib hydrochloride Inhibitor / Unkown
HY-19568B Peficitinib hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-112724 Ivarmacitinib Inhibitor 99.62% Phase 4
HY-16997 Itacitinib Inhibitor 99.97% Phase 3
HY-107361 Golidocitinib Inhibitor 99.54% Phase 3
HY-15999 Cerdulatinib Inhibitor 99.06% Phase 3
HY-12469 Decernotinib Inhibitor 99.91% Phase 3
HY-112708A Brepocitinib P-Tosylate Inhibitor 99.99% Phase 3
HY-174905 Quecitinib Inhibitor 99.35% Phase 3
HY-130247A Flonoltinib TFA Inhibitor 98.94% Phase 3
HY-10193 AZD-1480 Inhibitor 99.74% Phase 2
HY-126294 Londamocitinib Inhibitor 99.79% Phase 2
HY-15270 BMS-911543 Inhibitor 98.23% Phase 2
HY-156961 Cadefrecitinib Inhibitor 99.81% Phase 2
HY-16755 Solcitinib Inhibitor 99.51% Phase 2
HY-19631 Ilginatinib maleate Inhibitor 99.33% Phase 2
HY-159536 Frevecitinib Inhibitor 99.42% Phase 2
HY-101024 PF-06263276 Inhibitor ≥99.0% Phase 1
HY-179715 PROTAC JAK1/2 degrader-1 Degrader 99.47% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99244 Fezakinumab Modulator 99.9% Phase 2

Pre-clinical Phase

Bioactive Molecules (95)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W063968 RO8191 Activator ≥99.0% Unkown
HY-112708 Brepocitinib Inhibitor 99.95% Yes
HY-14435 Pyridone 6 Inhibitor 98.20% Unkown
HY-130247 Flonoltinib Inhibitor 99.48% Unkown
HY-145551 Atinvicitinib Inhibitor 98.62% Unkown
HY-10962 Momelotinib sulfate Inhibitor 98.63% Yes
HY-151385 VVD-118313 Inhibitor 99.47% Unkown
HY-14722 NVP-BSK805 Inhibitor 99.30% Unkown
HY-19631A Ilginatinib Inhibitor 99.81% Unkown
HY-100895 SAR-20347 Inhibitor 97.27% Unkown
HY-108264 TCS 21311 Inhibitor 99.49% Unkown
HY-162608 PROTAC JAK1 degrader 1 Degrader 99.97% Unkown
HY-151262 JAK-IN-23 Inhibitor 98.88% Unkown
HY-12589 ZM39923 hydrochloride Inhibitor 99.84% Unkown
HY-12538 Graveoline Inhibitor 99.93% Unkown
HY-15814 HG-7-85-01 Inhibitor 98.14% Unkown
HY-153701S Envudeucitinibum Inhibitor 99.56% Unkown
HY-14722A NVP-BSK805 dihydrochloride Inhibitor 99.36% Unkown
HY-19544 JAK3-IN-1 Inhibitor 99.31% Unkown
HY-15999A Cerdulatinib hydrochloride Inhibitor 98.96% Yes
HY-131906 JAK2-IN-7 Inhibitor 98.31% Unkown
HY-150720 TYK2-IN-12 Inhibitor 98.81% Unkown
HY-19631B Ilginatinib hydrochloride Inhibitor 98.92% Unkown
HY-151385A (R,R)-VVD-118313 Inhibitor 99.34% Unkown
HY-120469 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Inhibitor 99.80% Unkown
HY-153440 Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate Inhibitor 98.01% Unkown
HY-W394903 GS-829845 Inhibitor 99.19% Unkown
HY-139423 JAK1-IN-8 Inhibitor 95.0% Unkown
HY-162248 JAK1/2-IN-1 Inhibitor 98.36% Unkown
HY-143444 JAK-IN-20 Inhibitor 99.63% Unkown
HY-111750 JAK-IN-3 Inhibitor 98.92% Unkown
HY-126141 JAK/HDAC-IN-1 Inhibitor 98.63% Unkown
HY-N7653 Azaleatin Inhibitor 98.86% Unkown
HY-13961 GLPG0634 analog Inhibitor 98.07% Unkown
HY-179716 JAK1/2 ligand 1 Ligand 99.91% Unkown
HY-100849 JAK 3i Inhibitor 99.81% Unkown
HY-152080 Blovacitinib Inhibitor 99.71% Unkown
HY-116505 JAK1-IN-4 Inhibitor 99.26% Unkown
HY-13450 ZM 449829 Inhibitor 99.73% Unkown
HY-16997A Itacitinib adipate Inhibitor 99.18% Yes
HY-148060 JAK-IN-21 Inhibitor 99.72% Unkown
HY-161618 MJ04 Inhibitor 98.08% Unkown
HY-170772 Dual Cathepsin L/JAK-IN-1 Inhibitor 98.47% Unkown
HY-123115 Leucrose 98.53% Unkown
HY-181929 RAI-20 Inhibitor 98.66% Unkown
HY-182359 YYSW001 Inhibitor / Unkown
HY-14722C NVP-BSK805 trihydrochloride Inhibitor / Unkown
HY-170723 JAK-IN-39 Inhibitor / Unkown
HY-147975 JAK3-IN-12 Inhibitor / Unkown
HY-154994 JAK-IN-30 Inhibitor / Unkown
HY-188034 JAK-IN-44 Inhibitor / Unkown
HY-168339 Tyk2-IN-22 Inhibitor / Unkown
HY-175684 JAK2-IN-14 Inhibitor / Unkown
HY-143885 JAK1/TYK2-IN-3 Inhibitor / Unkown
HY-187103 JAK1-IN-22 Inhibitor / Unkown
HY-184592 JAK1-IN-21 Inhibitor / Unkown
HY-161259 JAK-IN-36 Inhibitor / Unkown
HY-139649 Ten01 Inhibitor / Unkown
HY-152080A (R)-Blovacitinib Inhibitor / Unkown
HY-174430 WWQ-131 Inhibitor / Unkown
HY-147754 JAK3/BTK-IN-6 Inhibitor / Unkown
HY-178282 JAK1-IN-19 Inhibitor / Unkown
HY-144440 JAK1-IN-9 Inhibitor / Unkown
HY-N14094 Tubulosine Inhibitor / Unkown
HY-187502 Jak1 RIMTAC-1 Degrader / Unkown
HY-175009 MRC-G-001 Inhibitor / Unkown
HY-175983 JAK1/TYK2-IN-5 Inhibitor / Unkown
HY-168893 K882 Inhibitor / Unkown
HY-170977 JAK1/STAT3-IN-1 Inhibitor / Unkown
HY-149296 JAK1-IN-12 Inhibitor / Unkown
HY-W635076 oJak-989 Inhibitor / Unkown
HY-108342 PF-00956980 Inhibitor / Unkown
HY-153566 JAK1-IN-10 Inhibitor / Unkown
HY-146727 JAK3-IN-11 Inhibitor / Unkown
HY-W064657 Momelotinib dihydrochloride Inhibitor 99.56% Unkown
HY-177006 JAK1/2-IN-2 Inhibitor / Unkown
HY-164111 JNK-IN-17 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-180274 JAK1/2-IN-3 Inhibitor / Unkown
HY-174999 JAK3-IN-18 Inhibitor / Unkown
HY-181872 JAK1-IN-20 Inhibitor / Unkown
HY-181528 JAK1/CDK7-IN-1 Inhibitor / Unkown
HY-176793 Embricitinib Inhibitor / Unkown
HY-161139 JAK1-IN-14 Inhibitor / Unkown
HY-168269 Tyk2-IN-20 Inhibitor / Unkown
HY-10963 Momelotinib mesylate Inhibitor / Unkown
HY-162862 JAK-IN-38 Inducer / Unkown
HY-183519 AH057 Inhibitor / Unkown
HY-185924 Domusiran Inhibitor / Unkown
HY-157121 JAK-IN-34 Inhibitor / Unkown
HY-123187 AS2553627 Inhibitor / Unkown
HY-162862 JAK-IN-38 Inhibitor / Unkown
HY-123939 JAK1/3-IN-1 Inhibitor / Unkown
HY-130247B Flonoltinib monomaleate Inhibitor / Unkown
HY-12589A ZM39923 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jak1 NCBI NCBI:3716