Braf - Braf transforming gene Gene

Also Known as B-raf; Braf2; Braf-2; C230098H17; D6Ertd631e; 9930012E13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 109880

About Braf

Chromosome 6: 39,580,171-39,702,397 reverse strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 220 orthologues, 23 paralogues and is associated with 76 phenotypes. Ubiquitous expression in frontal lobe adult (RPKM 6.7), bladder adult (RPKM 6.5) and 25 other tissues.

Summary

Enables protein kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; negative regulation of apoptotic process; and positive regulation of cellular component organization. Located in several cellular components, including cell body; mitochondrion; and neuron projection. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Langerhans-cell histiocytosis; cardiofaciocutaneous syndrome; melanoma; and thyroid gland papillary carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Braf Products (1)

mRNA Protein Name
NM_139294.5 NP_647455.3 serine/threonine-protein kinase B-raf

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16116448 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
17563371 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IMP
IMP: Inferred from mutant phenotype
18228248 MGI
acts upstream of or within CD4-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
23334952 MGI
acts upstream of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
15199148 MGI
acts upstream of or within T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
23334952 MGI
acts upstream of or within T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
18228248 MGI
acts upstream of or within alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
23334952 MGI
acts upstream of or within cell differentiation IGI
IGI: Inferred from genetic interaction
10704835 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
22628551 MGI
acts upstream of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
9207797 MGI
acts upstream of or within face development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within head morphogenesis IMP
IMP: Inferred from mutant phenotype
24733831 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
16342120 MGI
acts upstream of or within myeloid progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
15784729 MGI
acts upstream of or within negative regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
9207797 MGI
acts upstream of or within negative regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
15199148 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16980614 MGI
acts upstream of or within negative regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
23616533 MGI
acts upstream of or within positive T cell selection IMP
IMP: Inferred from mutant phenotype
23334952 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
22892241 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
15199148 MGI
acts upstream of or within positive regulation of axon regeneration IDA
IDA: Inferred from direct assay
24733831 MGI
acts upstream of or within positive regulation of axonogenesis IGI
IGI: Inferred from genetic interaction
24733831 MGI
acts upstream of or within positive regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
24733831 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
24733831 MGI
acts upstream of or within positive regulation of stress fiber assembly IGI
IGI: Inferred from genetic interaction
15199148 MGI
acts upstream of or within positive regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
15199148 MGI
acts upstream of or within positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
15199148 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
16342120 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
16342120 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
17563371 MGI
acts upstream of or within regulation of T cell differentiation IMP
IMP: Inferred from mutant phenotype
18228248 MGI
acts upstream of or within regulation of axon regeneration IGI
IGI: Inferred from genetic interaction
24733831 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
22891351 MGI
acts upstream of or within somatic stem cell population maintenance IGI
IGI: Inferred from genetic interaction
23022482 MGI
acts upstream of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
15199148 MGI
acts upstream of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
15199148 MGI
acts upstream of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
23616533 MGI
acts upstream of or within thymus development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within thyroid gland development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
16342120 MGI
Cellular Component GO Annotation Evidence References Source
located in cell body IDA
IDA: Inferred from direct assay
16980614 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15736129 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16342120 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
16342120 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
16116448 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
16980614 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15736129 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Braf Protein Structure

RBD_BRAF

RBD_BRAF: cd17134 (137 - 215)

C1_B-Raf

C1_B-Raf: cd20871 (213 - 272)

STKc_Raf

STKc_Raf: cd14062 (499 - 751)

  • 0
  • 200
  • 400
  • 600
  • 804 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase B-raf

  • B-Raf proto-oncogene serine/threonine-protein kinase (p94)

  • proto-oncogene B-Raf

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10201 Sorafenib 99.85% Yes
HY-14660 Dabrafenib 99.94% Yes
HY-12057 Vemurafenib 99.90% Yes
HY-15605 Encorafenib Inhibitor 99.94% Yes
HY-18652 Avutometinib Inhibitor 99.43% Unkown
HY-10201A Sorafenib tosylate 99.98% Yes
HY-10201S Sorafenib-d3 99.57% Unkown
HY-10201R Sorafenib (Standard) 99.71% Unkown
HY-10201AR Sorafenib tosylate (Standard) / Unkown

Clinical Phase

Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Phase
HY-132844 Tunlametinib Inhibitor 99.53% Phase 4
HY-10201S4 Sorafenib-d3 tosylate Inhibitor / Phase 4
HY-148439 Daraxonrasib Inhibitor 99.96% Phase 3
HY-112089 Naporafenib Inhibitor 99.92% Phase 3
HY-10320 Doramapimod Inhibitor 99.98% Phase 2
HY-101494 Temuterkib Inhibitor 99.93% Phase 2
HY-18972 Plixorafenib Inhibitor 99.80% Phase 2
HY-109080 Belvarafenib Inhibitor 98.97% Phase 2
HY-111940 LUT014 97.09% Phase 2
HY-114491A Rineterkib hydrochloride Inhibitor 99.81% Phase 2
HY-19343 XL-281 Inhibitor / Phase 2
HY-158115 NST-628 Inhibitor 99.35% Phase 1
HY-51424 PLX-4720 Inhibitor 99.90% Phase 1
HY-12558 LY3009120 98.66% Phase 1
HY-147268 Exarafenib Inhibitor 99.77% Phase 1
HY-153341 Tagarafdeg Degrader 99.41% Phase 1
HY-15610 GDC-0623 98.74% Phase 1
HY-18957 Lifirafenib Inhibitor 98.01% Phase 1
HY-159795 Claturafenib Inhibitor 99.95% Phase 1
HY-147405 Tinlorafenib Inhibitor 98.21% Phase 1
HY-15199 Agerafenib hydrochloride Inhibitor / Phase 1
HY-16063 ARQ-736 Inhibitor / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991507 SCT200 Inhibitor 99.09% Phase 2

Pre-clinical Phase

Bioactive Molecules (146)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50846 SCH772984 Inhibitor 99.83% Unkown
HY-10966 SB-590885 Inhibitor 99.77% Unkown
HY-12661A AMG PERK 44 99.67% Unkown
HY-50864 GDC-0879 Inhibitor 99.49% Unkown
HY-15200 Agerafenib Inhibitor 99.78% Unkown
HY-11004 AZ 628 99.44% Unkown
HY-18832 AWL-II-38.3 Inhibitor 99.68% Unkown
HY-136420 SJF-0628 99.90% Unkown
HY-15767 TAK-632 Inhibitor 98.93% Unkown
HY-W074340 tert-Butyl 5-aminopentanoate / Unkown
HY-Y1322 Triphenyl phosphate 99.67% Unkown
HY-137487 PROTAC BRAF-V600E degrader-1 Degrader 98.04% Unkown
HY-14177 Raf inhibitor 1 Inhibitor 98.03% Unkown
HY-202699 SHOC2-RAS PPI-IN-1 Inhibitor 99.50% Unkown
HY-17598 Rafoxanide 98.60% Unkown
HY-155736 MAPK-IN-2 Inhibitor 99.66% Unkown
HY-181067 IK-595 Inhibitor 98.55% Unkown
HY-145120 Mosperafenib Inhibitor 98.29% Unkown
HY-111758 PROTAC B-Raf degrader 1 Inhibitor 99.78% Unkown
HY-N9330 Broussoflavonol F 98.11% Unkown
HY-12846 CCT196969 Inhibitor 99.67% Unkown
HY-100510 RAF709 Inhibitor 99.92% Unkown
HY-114491 Rineterkib Inhibitor 98.79% Unkown
HY-18997 PLX7904 Inhibitor 98.72% Unkown
HY-10247 BRAF inhibitor Inhibitor 98.07% Unkown
HY-136567 TBAP-001 Inhibitor 98.97% Unkown
HY-12787 L-779450 98.75% Unkown
HY-107779 BI-882370 Inhibitor 98.55% Unkown
HY-77113 B-Raf IN 11 Inhibitor 99.46% Unkown
HY-12291 HG6-64-1 99.32% Unkown
HY-149464 ARN22089 Inhibitor 98.18% Unkown
HY-P10438 TAT-Braftide Inhibitor 99.52% Unkown
HY-107415 PLX7922 Inhibitor 98.68% Unkown
HY-P10436 Braftide Inhibitor 99.51% Unkown
HY-148059 Uplarafenib Inhibitor 99.63% Unkown
HY-18227 B-Raf IN 1 Inhibitor 99.94% Unkown
HY-18507 AD57 Inhibitor 98.27% Unkown
HY-10201S2 Sorafenib-13C,d3 98.35% Unkown
HY-117658 GSK-114 Inhibitor 99.52% Unkown
HY-153603 B-Raf IN 15 Inhibitor 98.0% Unkown
HY-142160 GNE-9815 Inhibitor 98.94% Unkown
HY-12847 CCT241161 99.77% Unkown
HY-144269 SHR902275 Inhibitor 99.80% Unkown
HY-149380 Vem-L-Cy5 Inhibitor 98.31% Unkown
HY-P11706 MS1 peptide 99.57% Unkown
HY-15605S Encorafenib-13C,d3 Inhibitor 98.14% Unkown
HY-RS01588 BRAF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-109080A Belvarafenib TFA Inhibitor ≥99.0% Unkown
HY-117273 AZ304 Inhibitor 99.77% Unkown
HY-130617 Pomalidomide-amido-C1-Br / Unkown
HY-164474 DS03090629 Inhibitor 99.16% Unkown
HY-150639 Everafenib Inhibitor / Unkown
HY-15198 KG5 Inhibitor 99.79% Unkown
HY-179505 OPN-9652 Inhibitor 98.84% Unkown
HY-10966R SB-590885 (Standard) Inhibitor 99.55% Unkown
HY-164524 SBI-0640726 Inhibitor 99.57% Unkown
HY-10201S1 Sorafenib-d4 99.9% Unkown
HY-108887 Anticancer agent 124 Inhibitor / Unkown
HY-11043 PF-0419789 Inhibitor / Unkown
HY-126298 RAF mutant-IN-1 Inhibitor / Unkown
HY-44237 Pomalidomide-CO-C-NH2 / Unkown
HY-103086 INU-152 Inhibitor / Unkown
HY-10966G SB-590885 (GMP) Inhibitor / Unkown
HY-115933 EGFR/BRAF-IN-1 Inhibitor / Unkown
HY-117707 EBI-907 Inhibitor / Unkown
HY-12057S Vemurafenib-d5 / Unkown
HY-12057S1 Vemurafenib-d7 / Unkown
HY-123799 SB-699393 Inhibitor / Unkown
HY-126180 BAY-866 Inhibitor / Unkown
HY-135216 Antiproliferative agent-54 Inhibitor / Unkown
HY-137488 PROTAC BRAF-V600E degrader-2 Inhibitor / Unkown
HY-13810 PF-04880594 Inhibitor / Unkown
HY-142820 B-Raf IN 5 Inhibitor / Unkown
HY-142830 B-Raf IN 6 Inhibitor / Unkown
HY-144271 RAF-IN-1 Inhibitor / Unkown
HY-146442 BRAF V600E/CRAF-IN-1 Inhibitor / Unkown
HY-146443 BRAF V600E/CRAF-IN-2 Inhibitor / Unkown
HY-146491 VEGFR-2/BRAF-IN-1 / Unkown
HY-146492 VEGFR-2/BRAF-IN-2 / Unkown
HY-147825 EGFR/BRAFV600E-IN-1 / Unkown
HY-147852 B-Raf IN 7 Inhibitor / Unkown
HY-147853 B-Raf IN 8 Inhibitor / Unkown
HY-147854 B-Raf IN 9 / Unkown
HY-149415 Multi-kinase-IN-5 Inhibitor / Unkown
HY-149517 EGFR/BRAFV600E-IN-2 / Unkown
HY-14979 ML786 Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-150250 B-Raf IN 13 Inhibitor / Unkown
HY-153914 B-Raf IN 14 Inhibitor / Unkown
HY-155942 B-Raf IN 19 Inhibitor / Unkown
HY-156554 Raf inhibitor 3 Inhibitor / Unkown
HY-156590 B-Raf IN 16 Inhibitor / Unkown
HY-158027 B-Raf IN 17 Inhibitor / Unkown
HY-162460 ERK1/2 inhibitor 10 Inhibitor / Unkown
HY-162873 MEK/RAF-IN-1 Inhibitor / Unkown
HY-164400 SIJ1777 / Unkown
HY-164428 AE 51310 Inhibitor / Unkown
HY-164492 LSN3074753 Inhibitor / Unkown
HY-168013 KRASG12C IN-14 Inhibitor / Unkown
HY-168125 JNK-IN-18 Inhibitor / Unkown
HY-168442 KRAS inhibitor-40 Inhibitor / Unkown
HY-168512 BRAFV600E-IN-1 Inhibitor / Unkown
HY-169869 pan-Raf/RTK inhibitor 1 Inhibitor / Unkown
HY-173164 EGFR/BRAFV600E-IN-4 / Unkown
HY-174274 ERK2-IN-6 Inhibitor / Unkown
HY-175435 CST905 Degrader / Unkown
HY-175726 BRAF ligand-Linker Conjugate 1 / Unkown
HY-175831 BRAFV600E-IN-2 Inhibitor / Unkown
HY-17598R Rafoxanide (Standard) / Unkown
HY-178995 BRAFV600E-IN-3 Inhibitor / Unkown
HY-179012 CDC20/HSP90-IN-1 / Unkown
HY-179098 Multi-target kinase-IN-8 / Unkown
HY-179559 OPN-9643 Inhibitor / Unkown
HY-180154 EGFR/BRAFV600E-IN-6 / Unkown
HY-180161 B-Raf-IN-20 Inhibitor / Unkown
HY-180419 SF-3-030 / Unkown
HY-181061 COX/5-LO-IN-2 / Unkown
HY-181130 Anticancer agent 299 / Unkown
HY-181131 Anticancer agent 300 / Unkown
HY-181913 KRAS G12C-IN-76 Inhibitor / Unkown
HY-181978 GIT1-IN-1 / Unkown
HY-18318 Takeda-6D Inhibitor 99.41% Unkown
HY-183674 MEK-IN-10 / Unkown
HY-184447 RN193 Inhibitor / Unkown
HY-184546 BRAFV600E ligand-1 Ligand / Unkown
HY-184581 Pomalidomide-5-C4-acid / Unkown
HY-184599 OICR-403184 Inhibitor / Unkown
HY-18507A AD57 hydrochloride Inhibitor / Unkown
HY-18652A Avutometinib potassium Inhibitor / Unkown
HY-187012 BRAF ligand-2 Ligand / Unkown
HY-18957B Lifirafenib maleate Inhibitor / Unkown
HY-E70649 BRAF V600E Recombinant Human Active Protein Kinase / Unkown
HY-N13841 2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose / Unkown
HY-RS01589 Braf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01590 Braf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120676 B-Raf IN 18 Inhibitor / Unkown
HY-14177A Raf inhibitor 1 dihydrochloride Inhibitor 99.29% Unkown
HY-164529 SJ-C1044 Inhibitor 98.63% Unkown
HY-164530 SKLB646 Inhibitor / Unkown
HY-177946 RAF-IN-4 Inhibitor / Unkown
HY-180329 CG 858-Neg / Unkown
HY-184875 B-Raf-IN-21 Inhibitor / Unkown
HY-186223 Enzyme modulator-1 Modulator / Unkown
HY-18817 AFG210 Inhibitor / Unkown
HY-41747 BRAF ligand-1 Ligand / Unkown
HY-51424S PLX-4720-d7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Braf NCBI NCBI:673