Inotodiol
Based on 1 Customer Validation
Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC50s in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.29%
- CAS 番号: 35963-37-2
- 分子式: C30H50O2
- 分子量:442.72
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COLO 205 | IC50 |
171 μM
Compound: 147
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Cytotoxicity against human COLO205 cells
Cytotoxicity against human COLO205 cells
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[PMID: 23092389] |
| HL-60 | IC50 |
25 μM
Compound: 147
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Cytotoxicity against human HL60 cells
Cytotoxicity against human HL60 cells
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[PMID: 23092389] |
| L1210 | IC50 |
110 μM
Compound: 147
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Cytotoxicity against mouse L1210 cells
Cytotoxicity against mouse L1210 cells
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[PMID: 23092389] |
| P388 | IC50 |
13.9 μM
Compound: 147
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Antiproliferative activity against mouse P388 cells
Antiproliferative activity against mouse P388 cells
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[PMID: 23092389] |
Inotodiol (0-100 μM, 72 h) inhibits the proliferation of cell HeLa, inhibits the cell migration and invasion, induces apoptosis i HeLa[2].
Inotodiol (0.1-10 μM, 28 h) inhibits the ROS generation, activates SOD, improves oxygen and glucose deprivation-induced mitochondrial dysfunction, reduces the leakage of lactate dehydrogenase and exhibits neuroprotective effect in PC12 cell[3].
Inotodiol (2 μg/mL, 24 h) inhibits H2O2-induced expression of IL-1β, IL-6, TNF-α and COX-2, and blocks the senescence in human dermal fibroblasts (HDF)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12
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Concentration:0.1-10 μM
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Incubation Time:28 h
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Result:Inproved the cell viability.
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Cell Line:HeLa
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Concentration:0-100 μM
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Incubation Time:72 h
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Result:Induced apoptosis.
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Cell Line:HeLa
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Concentration:30-50 μM
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Incubation Time:48 h
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Result:Upregulated the expression of p53, p21 and Bax, downregulated the expression of MMP-2/9, Bcl-2.
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Cell Line:HeLa
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Concentration:30-50 μM
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Incubation Time:48 h
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Result:Inhibited cell migration.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse passive anaphylaxis models[5]
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Dosage:2-20 mpk
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Administration:po, once daily for 3-5 days
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Result:Reduced the decrease in body temperature and ear swelling.
化学情報
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CAS 番号 35963-37-2
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性状 Solid
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分子量 442.72
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分子式 C30H50O2
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Color White to off-white
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SMILES
C[C@@]1(CC[C@@H]2O)C(CC[C@@]34C)=C(CC[C@@]1([H])C2(C)C)[C@@]3(CC[C@]4([H])[C@H](C)[C@H](O)C/C=C(C)\C)C
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Structure Classification
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Initial Source
Inonotus obliquus Chaga
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Nakata T, et al. Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem. 2007;15(1):257-264. [Content Brief]
[2]. Zhang SD, et al., Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells. Phytomedicine. 2019 Jul;60:152957. [Content Brief]
[4]. Lee SH, et al., Antiaging effect of inotodiol on oxidative stress in human dermal fibroblasts. Biomed Pharmacother. 2022 Sep;153:113311. [Content Brief]
[5]. Liu Y, et al., Inotodiol, an antiasthmatic agent with efficacy and safety, preferentially impairs membrane-proximal signaling for mast cell activation. Int Immunopharmacol. 2023 Apr;117:109854. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Inotodiol 関連分類
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