SC-60
SC-60 is a derivative of Sorafenib (HY-10201). SC-60 exerts its anti-tumor effect by activating the phosphatase activity of SHP-1, thereby inhibiting the STAT3 signaling pathway. SC-60 exhibits strong proliferation inhibitory activity in various hepatocellular carcinoma (HCC) cell lines. SC-60 downregulates the expression of downstream anti-apoptotic proteins (such as Bcl-2, Cyclin D1, Survivin), ultimately inducing caspase-dependent apoptosis. SC-60 significantly inhibits tumor growth in xenograft tumor models. SC-60 can be used for the study of HCC.
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- CAS. Nr.: 1421677-31-7
- Formel: C29H22N4O3
- Molecular Weight:474.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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STAT3 |
Bcl-2 |
Chemical Information
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CAS. Nr. 1421677-31-7
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Molecular Weight 474.51
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Formel C29H22N4O3
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SMILES
N#CC1=CC=C(C=C1)OC2=CC(NC(NC3=CC=C(C)C(OC4=CC=C(C=C4)C#N)=C3)=O)=CC=C2C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SC-60 Related Classifications
HY-W717425 Related Classifications
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