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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
63 Results for "
parasite infection
" in MedChemExpress (MCE) Product Catalog:
Products (63)
63 Results for "parasite infection" in MCE Product Catalog:
Cat. No.: HY-N10197
CAS No.: 2826264-81-5
Category:
Infection Alkaloids Microorganisms Other Alkaloids Coumarins Phenols Polyphenols Phenylpropanoids Disease Research Fields
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Cat. No.: HY-170777
CAS No.: 3065121-94-7
SLU-10906 (Compound 63) is an orally active and potent Cryptosporidium inhibitor. SLU-10906 is active against the parasite in a cell-based infection model (EC50= 0.19 μM) and non-cytotoxic. SLU-10906 is promising for research of cryptosporidiosis .
Cat. No.: HY-151484
CAS No.: 2738381-52-5
Anti-infective agent 4 (compound 73) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.016 μM. Anti-infective agent 4 effectively reduces parasite burden in vivo. Anti-infective agent 4 can be used for the research of infection .
Cat. No.: HY-113648
CAS No.: 1025400-45-6
LP10 is a non-azole CYP51 inhibitor with activity against Trypanosoma cruzi infection. Treatment with LP10 blocks the 14α-demethylation step, leading to disruption of the parasite cell membrane and ultimately triggering the death of important clinically relevant amoeba stages .
Cat. No.: HY-149093
CAS No.: 1638956-72-5
Antileishmanial agent-14 is a sulfuretin analog with potential activity against the parasite Leishmania donovani promastigotes (IC50=4.1 μM). Antileishmanial agent-14 also inhibits infection by L. donovani amastigotes (IC50=11.1 μM) .
Cat. No.: HY-123444
CAS No.: 129297-22-9
Research Areas:
Kijimicin is a polyether ionophore antibiotic originally discovered in Actinomadura sp. MI215-NF3. inhibits HIV-1 replication and reduces the infectivity of progeny viral particles. Kijimicin exhibits inhibitory activity against intracellular T. gondii (IC50 = 45.6 nM), extracellular parasites (IC50 = 216.6 pM) and C. parvum (IC50 = 7.7 nM), and controls acute T. gondii infection in mice. Kijimicin can be used for research on HIV, toxoplasmosis, cryptosporidiosis, and bacterial infections .
Cat. No.: HY-128398
CAS No.: 1236038-23-5
CpCDPK1/TgCDPK1-IN-2 (Compound 7r) is a CpCDPK1 and TgCDPK1 inhibitor with IC50 values of 12 and 5 nM, respectively. CpCDPK1/TgCDPK1-IN-2 can be used in the research of apicomplexan protozoa-related diseases, such as the research of T. gondii, C. parvum and C. hominus infection .
Cat. No.: HY-128399
CAS No.: 1092788-87-8
CpCDPK1/TgCDPK1-IN-3 (Compound 20) is a CpCDPK1 and TgCDPK1 inhibitor with IC50 values of 0.003 and 0.0036 µM, respectively. CpCDPK1/TgCDPK1-IN-3 can be used in the research of apicomplexan protozoa-related diseases, such as the research of T. gondii, C. parvum and C. hominus infection .
Cat. No.: HY-124623
CAS No.: 2222660-40-2
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.
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Sulfalene (Standard) is the analytical standard of Sulfalene. This product is intended for research and analytical applications. Sulfalene (Sulfametopyrazine; AS-18908) is an orally active antimalarial agent. Sulfalene competes for para-aminobenzoic acid binding in plasmodial folic acid synthesis. Sulfalene, combined with Trimethoprim (HY-B0510), clears parasites, resolves fever, and resists induced resistance against drug-sensitive and drug-resistant Plasmodium falciparum. Sulfalene can be used for the research of acute falciparum malaria and Schistosoma mansoni infection .
Cat. No.: HY-P990804
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Cat. No.: HY-L002
4,884 compounds
An infection occurs when another organism enters a person’s body and causes disease. The organisms that cause infections are very diverse and can include things like viruses, bacteria, fungi, and parasites. The immune system is an effective barrier against infectious agents.
MCE provides a unique collection of 4,884 anti-infective compounds with anti-bacterial, anti-viral, anti-fungal and anti-parasite activities that can be used for drug screening and other research in anti-microbial area.
Cat. No.: HY-12641B
CAS No.: 26155-20-4
Pyrantel hydrochloride is an orally active antiparasitic agent. Pyrantel hydrochloride induces spastic paralysis in parasites via actions on neural and muscular cholinergic receptors as a nicotinic acetylcholine receptor (nAChR) agonist. Pyrantel hydrochloride eliminates both immature and mature endoparasites in horses. Pyrantel hydrochloride can be used in research related to parasitic infections .
Cat. No.: HY-171215
CAS No.: 2226228-02-8
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ML901 is an antimalarial agent with an IC50 value of 2 nM against the malaria parasite. ML901 specifically inhibits the tyrosine tRNA synthetase of the malaria parasite (PfYRS) through "receptor hijacking". ML901 exhibits full life-cycle killing activity in the malaria mouse model. ML901 can be used for studying malaria parasite infection .
Cat. No.: HY-123444A
CAS No.: 129388-64-3
Research Areas:
Kijimicin sodium is a polyether ionophore antibiotic originally discovered in Actinomadura sp. MI215-NF3. Kijimicin sodium inhibits HIV-1 replication and reduces the infectivity of progeny viral particles. Kijimicin sodium exhibits inhibitory activity against intracellular T. gondii (IC50 = 45.6 nM), extracellular parasites (IC50 = 216.6 pM) and C. parvum (IC50 = 7.7 nM), and controls acute T. gondii infection in mice. Kijimicin sodium can be used for research on HIV, toxoplasmosis, cryptosporidiosis, and bacterial infections .
Cat. No.: HY-183747
CAS No.: 1916476-01-1
Antitrypanosomal agent 32 is a antitrypanosomal agent with nanomolar potency against multiple Trypanosoma cruzi strains, including CL-Brener, Y, Dm28c-Luc and Tulahuen. Antitrypanosomal agent 32 sustains inhibition of parasite growth after washing and reduces parasitemia levels in BALB/c mice. Antitrypanosomal agent 32 can be used for the research of trypanosome infection .
Cat. No.: HY-184074
CAS No.: 2152662-88-7
Enfiborole is an oxaborolane ester inhibitor with trypanocidal activity against parasites. Enfiborole displays IC50 values ≤ 20 nM against Trypanosoma brucei and Trypanosoma cruzi, and its IC50 against replicating trypanosomes ranges from 21 to 999 nM. Enfiborole inhibits the growth of Trypanosoma brucei, suppresses hypoxanthine incorporation in replicating trypanosomes, and inhibits the growth of Trypanosoma cruzi amastigotes. Enfiborole can be used in studies related to trypanosome infections .
Stilbazium iodide is an orally effective pyridinium quaternary ammonium repellent. Stilbazium (iodide) exhibits broad-spectrum activity against a variety of human and animal intestinal parasites. Stilbazium iodide eliminates both mature and immature worms, reduces egg counts, reddens feces, and causes mild gastrointestinal irritation. Stilbazium iodide can be used in research related to intestinal parasitic infections including pinworm, whipworm, and strongyloidiasis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
