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Pentadecanoic acid

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.

For research use only. We do not sell to patients.

Purity: 99.92%
CAS No.: 1002-84-2
Formula: C₁₅H₃₀O₂
Molecular Weight:242.40

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Pentadecanoic acid Chemical Structure

CAS No.: 1002-84-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

All JAK Isoforms :

All STAT Isoforms :

All PPAR Isoforms :

All p38 MAPK Isoforms :

All JNK Isoforms :

All ERK Isoforms :

All Caspase Isoforms :

In Vitro

Pentadecanoic acid (50-200 μM, 48 hours) induces apoptosis in MCF-7/SC breast cancer stem-like cells by inhibiting the JAK2/STAT3 signaling pathway and suppresses their proliferation and migration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MCF-7/SC breast cancer stem-like cells
Concentration:

50, 100, 150, 200 μM
Incubation Time:

48 hours
Result:

Significantly reduced MCF-7/SC cell viability, showing time- and dose-dependent cytotoxic effects.

Cell Invasion Assay^[1]

Cell Line:

MCF-7/SC breast cancer stem-like cells
Concentration:

100 μM
Incubation Time:

48 hours
Result:

Significantly reduced the ability of MCF-7/SC cells to penetrate Matrigel, with a markedly lower number of invasive cells compared to the control group.

Cell Cycle Analysis^[1]

Cell Line:

MCF-7/SC breast cancer stem-like cells
Concentration:

50, 100, 150, 200 μM
Incubation Time:

48 hours
Result:

Led to a significant accumulation of MCF-7/SC cells in the Sub-G1 phase and reduced the proportion of S-phase and G2/M-phase cells, suggesting cell cycle arrest.

In Vivo

Pentadecanoic acid (1% w/w, dietary intake, from gestation to the end of lactation) induces mild glucose intolerance during pregnancy in C57BL6/J mice, partly mediated through activation of PPARα and MAPK signaling pathways, and promoted offspring growth and enhanced antioxidant capacity during lactation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

1% Pentadecanoic acid (PA) diet-induced gestational glucose intolerance C57BL6/J mouse model^[2]
Dosage:

1% (Pentadecanoic acid ethyl ester was incorporated into a low-fat diet (LFD) by replacing 10 g/kg soybean oil, achieving a final concentration of 1% (w/w), with a total feed composition of 1000 g/kg as an example)
Administration:

Dietary intake, from gestation to the end of lactation
Result:

Increased PA and heptadecanoic acid (C17:0) levels in maternal and fetal tissues;
Induced mild insulin resistance during pregnancy and activated PPARα and MAPK signaling pathways;
Increased maternal oxidative stress but reduced maternal fat deposition and promoted offspring growth during lactation;
Reduced plasma and liver triglyceride (TG) levels in offspring and enhanced antioxidant capacity.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1002-84-2
Appearance Solid
Molecular Weight 242.40
Formula C₁₅H₃₀O₂
Color White to off-white
SMILES

O=C(CCCCCCCCCCCCCC)O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Journal Impact Factor

BMC Med

Integration of gut microbiome and lipid metabolism reveals the anti-cancer effects of pentadecanoic acid on bladder cancer. [Abstract]

2025 Dec 3;24(1):10. PMID: 41339867

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (257.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.1254 mL

20.6271 mL

41.2541 mL

5 mM

0.8251 mL

4.1254 mL

8.2508 mL

10 mM

0.4125 mL

2.0627 mL

4.1254 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (8.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (8.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. To N B, et al. Pentadecanoic acid, an odd-chain fatty acid, suppresses the stemness of MCF-7/SC human breast cancer stem-like cells through JAK2/STAT3 signaling[J]. Nutrients, 2020, 12(6): 1663. [Content Brief]

[2]. Wang J, et al. Pentadecanoic acid (C15: 0, PA) induces mild maternal glucose intolerance and promotes the growth of the offspring partly through up-regulating liver PPARα and MAPK signaling pathways[J]. Food & Function, 2024, 15(23): 11400-11414. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.1254 mL	20.6271 mL	41.2541 mL	103.1353 mL
	5 mM	0.8251 mL	4.1254 mL	8.2508 mL	20.6271 mL
	10 mM	0.4125 mL	2.0627 mL	4.1254 mL	10.3135 mL
	15 mM	0.2750 mL	1.3751 mL	2.7503 mL	6.8757 mL
	20 mM	0.2063 mL	1.0314 mL	2.0627 mL	5.1568 mL
	25 mM	0.1650 mL	0.8251 mL	1.6502 mL	4.1254 mL
	30 mM	0.1375 mL	0.6876 mL	1.3751 mL	3.4378 mL
	40 mM	0.1031 mL	0.5157 mL	1.0314 mL	2.5784 mL
	50 mM	0.0825 mL	0.4125 mL	0.8251 mL	2.0627 mL
	60 mM	0.0688 mL	0.3438 mL	0.6876 mL	1.7189 mL
	80 mM	0.0516 mL	0.2578 mL	0.5157 mL	1.2892 mL
	100 mM	0.0413 mL	0.2063 mL	0.4125 mL	1.0314 mL

Keywords

Pentadecanoic acid

1 Cited Publications

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Pentadecanoic acid

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