Ahr - aryl hydrocarbon receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25690

Summary

Enables nuclear receptor activity and toxic substance binding activity. Involved in several processes, including cellular response to organic cyclic compound; negative regulation of Alkaline Phosphatase activity; and regulation of cellular macromolecule biosynthetic process. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 85. Orthologous to human AHR (Aryl Hydrocarbon Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ahr Products (3)

mRNA Protein Name
NM_001308254.1 NP_001295183.1 aryl hydrocarbon receptor isoform 2
NM_001308255.1 NP_001295184.1 aryl hydrocarbon receptor isoform 3
NM_013149.3 NP_037281.3 aryl hydrocarbon receptor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables arachidonate omega-hydroxylase activity IMP
IMP: Inferred from mutant phenotype
19889059 RGD
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
7812217 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11259609 RGD
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
9056263 RGD
enables sequence-specific double-stranded DNA binding IMP
IMP: Inferred from mutant phenotype
15492120 RGD
enables toxic substance binding IDA
IDA: Inferred from direct assay
18938125 RGD
Biological Process GO Annotation Evidence Références Source
involved in aflatoxin metabolic process IEP
IEP: Inferred from expression pattern
28959666 RGD
involved in cellular response to 2,3,7,8-tetrachlorodibenzodioxine IDA
IDA: Inferred from direct assay
9658193 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
9804617 RGD
involved in cellular response to glucocorticoid stimulus IEP
IEP: Inferred from expression pattern
17690134 RGD
involved in cellular response to toxic substance IMP
IMP: Inferred from mutant phenotype
31746392 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
9813174 RGD
involved in conditioned taste aversion IMP
IMP: Inferred from mutant phenotype
30769105 RGD
involved in contact inhibition IMP
IMP: Inferred from mutant phenotype
17952121 RGD
involved in estrogen receptor signaling pathway IDA
IDA: Inferred from direct assay
26372666 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
21666223 RGD
involved in mammary duct terminal end bud growth IDA
IDA: Inferred from direct assay
26372666 RGD
involved in negative regulation of DNA biosynthetic process IDA
IDA: Inferred from direct assay
12193573 RGD
involved in negative regulation of DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
17952121 RGD
involved in negative regulation of alkaline phosphatase activity IDA
IDA: Inferred from direct assay
12193573 RGD
involved in negative regulation of calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
12193573 RGD
involved in negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17952121 RGD
involved in negative regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
12193573 RGD
involved in negative regulation of osteoblast proliferation IDA
IDA: Inferred from direct assay
12193573 RGD
involved in nitric oxide metabolic process IEP
IEP: Inferred from expression pattern
31489946 RGD
involved in omega-hydroxylase P450 pathway IMP
IMP: Inferred from mutant phenotype
19889059 RGD
involved in ovarian follicle development IMP
IMP: Inferred from mutant phenotype
20466593 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
32913241 RGD
involved in positive regulation of mating-type specific transcription, DNA-templated IDA
IDA: Inferred from direct assay
9056263 RGD
involved in protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
32913241 RGD
involved in reactive oxygen species biosynthetic process IMP
IMP: Inferred from mutant phenotype
35788946 RGD
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
7812217 RGD
involved in regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
33766215 RGD
involved in regulation of eating behavior IDA
IDA: Inferred from direct assay
27594096 RGD
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
23999541 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
20176079 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18059014 RGD
involved in response to organic cyclic compound IMP
IMP: Inferred from mutant phenotype
20403408 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
9653054 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
9658193 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
10053172 RGD
involved in tissue remodeling IEP
IEP: Inferred from expression pattern
23887904 RGD
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7812217 RGD
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18515748 RGD
located in nucleus IDA
IDA: Inferred from direct assay
7812217 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aryl hydrocarbon receptor

  • ah receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (11)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-109044 Tapinarof Agonist 99.95% Unkown
HY-A0083 Methacholine chloride Agonist ≥98.0% Yes
HY-N0178 Diosmin Agonist 98.62% Yes
HY-B0311 Carbidopa Modulator 99.84% Yes
HY-W017113 2-Mercaptobenzothiazole 99.85% Yes
HY-B0311A Carbidopa monohydrate Modulator 99.84% Yes
HY-B0678 Metaxalone 99.77% Unkown
HY-17357 Nepafenac Inhibitor 99.56% Unkown
HY-17479 Amfenac / Unkown
HY-A0083B Methacholine bromide Agonist / Unkown
HY-B0678R Metaxalone (Standard) / Unkown

Clinical Phase

Bioactive Molecules (11)
Cat. No. Nom du produit Effect
Pureté Phase
HY-N0170 Indole-3-carbinol 99.16% Phase 3
HY-B2132 Tryptamine 99.89% Phase 3
HY-W013053 Dibenz[a,h]anthracene Inducer 98.0% Phase 3
HY-15001 Stemregenin 1 Antagonist 99.95% Phase 2
HY-16031B AFP464 dihydrochloride 99.45% Phase 2
HY-16031 AFP464 free base / Phase 2
HY-16031A AFP464 / Phase 2
HY-135829 BAY 2416964 Antagonist 99.59% Phase 1
HY-111449 BAY-218 Antagonist 99.78% Phase 1
HY-N0170R Indole-3-carbinol (Standard) 98.31% Phase 1
HY-136220 AHR antagonist 5 Antagonist 98.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (170)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-12684 CH-223191 Antagonist 99.82% Unkown
HY-12028 PD98059 99.94% Unkown
HY-15484 Pifithrin-α hydrobromide 99.94% Unkown
HY-12451 FICZ Agonist 99.42% Unkown
HY-W028393 Indole-3-pyruvic acid Agonist 99.55% Unkown
HY-19317 ITE Agonist 99.27% Unkown
HY-102023 GNF351 Antagonist 99.87% Unkown
HY-W011910 Potassium 1H-indol-3-yl sulfate 99.95% Unkown
HY-W015273A trans-3-Indoleacrylic acid Inhibitor 99.77% Unkown
HY-114740 β-Naphthoflavone 99.86% Unkown
HY-W007355 Skatole 99.99% Unkown
HY-141609 IK-175 Inhibitor 99.89% Unkown
HY-122208 SGA360 Inhibitor 99.93% Unkown
HY-133677 Mono(2-ethyl-5-hydroxyhexyl) phthalate 99.03% Unkown
HY-103220 6,2',4'-Trimethoxyflavone Antagonist 98.02% Unkown
HY-W011338 Benzyl butyl phthalate Activator 97.0% Unkown
HY-134217 KYN-101 Inhibitor 98.03% Unkown
HY-119019 ASB14780 Inhibitor 99.58% Unkown
HY-B0845 Prochloraz 99.85% Unkown
HY-W014502 D-Kynurenine Agonist 99.94% Unkown
HY-W014075 1-Hydroxypyrene 99.38% Unkown
HY-103221 MeBIO 98.0% Unkown
HY-18619 YL-109 Modulator 98.91% Unkown
HY-132429S Potassium 1H-indol-3-yl sulfate-d5 99.77% Unkown
HY-112628 CAY10464 Antagonist 99.77% Unkown
HY-N1939 Icariside I 98.76% Unkown
HY-144339 AhR agonist 2 99.89% Unkown
HY-135750 VAF347 Agonist 99.75% Unkown
HY-12545 Brevetoxin-3 Activator 95.0% Unkown
HY-112629 PDM2 Antagonist 98.96% Unkown
HY-117532 PenCB Inducer 99.82% Unkown
HY-77278 25-Hydroxytachysterol3 Agonist 98.07% Unkown
HY-15001G Stemregenin 1 (GMP) Antagonist / Unkown
HY-N0914 Ajugol 99.61% Unkown
HY-111450 CB7993113 Antagonist 98.0% Unkown
HY-D0932 Sudan IV 98.0% Unkown
HY-G0006 Omeprazole sulfide 99.88% Unkown
HY-W014701 1,4-Dihydroxy-2-naphthoic acid 99.60% Unkown
HY-117102 ANI-7 Activator 99.01% Unkown
HY-G0007 Omeprazole sulfone Control 99.23% Unkown
HY-118438 10-Cl-BBQ Agonist 99.46% Unkown
HY-W718300 Indole-3-pyruvic acid-d5 96.31% Unkown
HY-W011910S Potassium 1H-indol-3-yl sulfate-d4 Activator 99.9% Unkown
HY-17663 KMR-206 98.86% Unkown
HY-W011338S Benzyl butyl phthalate-d4 98.38% Unkown
HY-N0586A Norisoboldine hydrochloride Agonist 99.87% Unkown
HY-124421 5F-203 Inducer 98.04% Unkown
HY-RS00483 AHR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B0973 Dibenzothiophene Inhibitor 99.92% Unkown
HY-112627 CAY 10465 Agonist 98.30% Unkown
HY-114682 Lenperone Antagonist 98.11% Unkown
HY-N4095 Brevifolincarboxylic acid Inhibitor 99.90% Unkown
HY-130256 β-NF-JQ1 98.05% Unkown
HY-105791 Sulazepam 99.56% Unkown
HY-147128 PY109 Agonist 99.15% Unkown
HY-34505 1-Methyl-5-pyrazolecarboxylic acid 99.83% Unkown
HY-W012278 Benz[a]anthracene Ligand 99.90% Unkown
HY-111441 1,4-Chrysenequinone Activator 99.97% Unkown
HY-120377 CYP1A1 inhibitor 8a Inhibitor 98.00% Unkown
HY-124404 12(R)-HETE 99.90% Unkown
HY-125019 iJak-381 Inhibitor 99.86% Unkown
HY-135831 AHR antagonist 2 Antagonist 99.30% Unkown
HY-B0311AS Carbidopa-d3 monohydrate Modulator 98.53% Unkown
HY-W014075S 1-Hydroxypyrene-d9 99.95% Unkown
HY-W764758 3-OH-Kynurenamine dihydroiodide Activator 99.56% Unkown
HY-12028R PD98059 (Standard) 99.72% Unkown
HY-103222 DiMNF Modulator 98.46% Unkown
HY-103223 Phortress Inducer 98.19% Unkown
HY-N0586 Norisoboldine Agonist 99.93% Unkown
HY-W251708 AHR 10240 / Unkown
HY-114740R β-Naphthoflavone (Standard) 99.49% Unkown
HY-RS16533 Ahr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100242 Mivotilate Activator 99.58% Unkown
HY-104026CS L-Kynurenine-13C10 sulfate hemihydrate Agonist 99.90% Unkown
HY-118474 GW 610 Activator 99.78% Unkown
HY-118780 CHD-5 Antagonist 98.0% Unkown
HY-17357S Nepafenac-d5 Inhibitor 98.84% Unkown
HY-N10123 Indolokine A5 Agonist 98.0% Unkown
HY-N6264 26-Deoxyactein Inhibitor 99.76% Unkown
HY-W014502R D-Kynurenine (Standard) Agonist 99.99% Unkown
HY-W046846 Corannulene Agonist 97.31% Unkown
HY-W338764 AHR agonist 3 99.79% Unkown
HY-133677S Mono(2-ethyl-5-hydroxyhexyl) phthalate-d4 96.23% Unkown
HY-154825 20-Hydroxyvitamin D3 ≥98.0% Unkown
HY-W095381 N-Methylscatole Agonist 98.45% Unkown
HY-131340 LASSBio-1632 Inhibitor / Unkown
HY-136220A AHR antagonist 5 hemimaleate Antagonist / Unkown
HY-101745B Rocastine fumarate Inhibitor / Unkown
HY-101802 Fluzinamide / Unkown
HY-104026B L-Kynurenine sulfate Agonist / Unkown
HY-106487 Pridefine Inhibitor / Unkown
HY-111157 Dezinamide / Unkown
HY-114682A Lenperone hydrochloride Antagonist / Unkown
HY-116148 AHR-11797 / Unkown
HY-116638 AHR-5333 Inhibitor / Unkown
HY-116638A AHR-5333 mandelate Inhibitor / Unkown
HY-117774 AHR-2244 hydrochloride / Unkown
HY-118792 AHR activator 1 / Unkown
HY-119018 AHR-6293 Inhibitor / Unkown
HY-119960 AHR-10037 Inhibitor / Unkown
HY-120677 AHR-15010 Inhibitor / Unkown
HY-123432 AHR-13268D Inhibitor / Unkown
HY-123461 Sul-121 hydrochloride Inhibitor / Unkown
HY-124021 Benzyl 2-naphthyl ether 99.44% Unkown
HY-125926A (S)-2-Ketodoxapram / Unkown
HY-125926S 2-Ketodoxapram-d5 / Unkown
HY-129305 Tampramine fumarate Inhibitor / Unkown
HY-130269 β-Naphthoflavone-CH2-OH / Unkown
HY-130270 AhR Ligand-Linker Conjugates 1 / Unkown
HY-130842 β-Naphthoflavone-CH2-Br / Unkown
HY-132974 Aminoflavone / Unkown
HY-135671 AhR modulator-1 / Unkown
HY-135830 AHR antagonist 4 Antagonist / Unkown
HY-136876 AHR-12234 citrate / Unkown
HY-136891 AHR-16303B / Unkown
HY-139117 6,2′,4′-Trimethoxyflavone Antagonist / Unkown
HY-155505 AHR agonist 4 Agonist / Unkown
HY-156908 3-OH-Kynurenamine Activator / Unkown
HY-158167 AhR agonist 5 Agonist / Unkown
HY-158168 AhR agonist 6 Agonist / Unkown
HY-158169 AhR agonist 7 Agonist / Unkown
HY-161649 hCYP1B1-IN-2 Inhibitor / Unkown
HY-168033 AhR agonist 8 Agonist / Unkown
HY-169753 AHR-IN-1 Inhibitor / Unkown
HY-173393 LXRα agonist 1 Agonist / Unkown
HY-17479B Amfenac sodium / Unkown
HY-175785 X15695 98.45% Unkown
HY-176771 Tapinarof prodrug-1 / Unkown
HY-178053 AHR agonist 10 / Unkown
HY-181472 10(11)-Cl-BBQ / Unkown
HY-181629 ZSTK3744 / Unkown
HY-181629A ZSTK3744 hydrochloride / Unkown
HY-182495 Penisimplicissin Inhibitor / Unkown
HY-184554 ZY-MY-111 Inhibitor / Unkown
HY-19826 Isofistularin-3 / Unkown
HY-A0083C Methacholine iodide Agonist / Unkown
HY-B0311D Carbidopa hydrochloride Modulator / Unkown
HY-B0311S1 Carbidopa-d3-1 Modulator / Unkown
HY-B0678S Metaxalone-d3 98.0% Unkown
HY-B0678S1 Metaxalone-d6 / Unkown
HY-B0973S Dibenzothiophene-d8 Inhibitor / Unkown
HY-G0007S Omeprazole sulfone-d3 Control / Unkown
HY-G0007S1 Omeprazole sulfone-13C,d3 Control / Unkown
HY-N12537A (2R,3S)-PD-1/PD-L1-IN-38 / Unkown
HY-N16465 Cinnamtannin D1 Inhibitor / Unkown
HY-W716464 Prochloraz-d7 / Unkown
HY-101745 Rocastine Inhibitor / Unkown
HY-104026BS L-Kynurenine-13C10 sulfate Agonist / Unkown
HY-107063 AHR-1911 Activator 99.66% Unkown
HY-109044S Tapinarof-d5 Agonist / Unkown
HY-118910 AHR-14310C Antagonist / Unkown
HY-119991 AHR-9294 Inhibitor / Unkown
HY-125926S1 2-Ketodoxapram-d4 / Unkown
HY-128229 AHR antagonist 6 Antagonist / Unkown
HY-129247 Versicolorin A / Unkown
HY-130456 AHR 10718 Inhibitor / Unkown
HY-148637 Picoberin Agonist / Unkown
HY-163665 AHR antagonist 8 / Unkown
HY-167214 (+)-Ketodoxapram / Unkown
HY-170514 1,2,3,7,8,9-Hexachlorodibenzofuran Ligand / Unkown
HY-177563 AhR modulator-2 Activator / Unkown
HY-20888 3'-Methoxy-4'-nitroflavone / Unkown
HY-B0845R Prochloraz (Standard) / Unkown
HY-D0932S Sudan IV-d6 / Unkown
HY-N16435 Plumericin / Unkown
HY-RS22964 Ahr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00010 Dazopride / Unkown
HY-W007355S2 Skatole-13C6 / Unkown
HY-W587465 9,10-Dichlorophenanthrene / Unkown
HY-W714200 Neburon / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ahr NCBI NCBI:196