F2 - coagulation factor II Gene

Also Known as Cf2; FII; Cf-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14061

Summary

This gene encodes a vitamin K-dependent glycoprotein coagulation factor that plays an important role in the process of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that undergoes enzymatic cleavage by the coagulation Factor Xa to form an active serine protease that converts soluble fibrinogen to insoluble fibrin clot. Most of the mice lacking the encoded protein die at an embryonic stage due to defects in yolk sac vasculature, while the rare nenonates succumb to hemorrhage on the first postnatal day. [provided by RefSeq, Apr 2015]

F2 Products (1)

mRNA Protein Name
NM_010168.3 NP_034298.1 prothrombin preproprotein
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
26742564 MGI
enables peptidase activity IMP
IMP: Inferred from mutant phenotype
18305483 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7608171 MGI
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
18398001 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prothrombin

  • thrombin

Recombinant F2 Proteins

Cat. No. 상품명 Accession Purity
HY-P72944 Coagulation Factor II/F2 Protein, Mouse (HEK293, His) Q3TJ94 (Q25-G618) ≥ 95%, as determined by reducing SDS-PAGE.

F2 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P82008 F2 Antibody (YA1753) WB, IHC-P Mouse, Rat
HY-P82008A Prothrombin Antibody (YA1753)(PBS only) WB, IHC-P Mouse, Rat

Orthologs Information

Species Symbol Source ID
Homo sapiens F2 NCBI NCBI:2147