Il4 - interleukin 4 Gene

Also Known as Il4e12

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 287287

About Il4

Primary_assembly 10: 37,771,203-37,776,750 reverse strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 92 orthologues and is associated with 113 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable cytokine activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of leukocyte migration; and regulation of defense response. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; autoimmune thyroiditis; and pelvic inflammatory disease. Biomarker of several diseases, including cerebrovascular disease (multiple); interstitial lung disease (multiple); irritant dermatitis; primary biliary cholangitis; and rhinitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic Cancer (multiple). Orthologous to human IL4 (interleukin 4). [provided by Alliance of Genome Resources, Apr 2022]

Il4 Products (1)

mRNA Protein Name
NM_201270.1 NP_958427.1 interleukin-4 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to mercury ion IEP
IEP: Inferred from expression pattern
7657819 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
19617880 RGD
involved in microglial cell activation IDA
IDA: Inferred from direct assay
23786632 RGD
involved in negative regulation of acute inflammatory response IDA
IDA: Inferred from direct assay
17250684 RGD
involved in negative regulation of chronic inflammatory response IDA
IDA: Inferred from direct assay
16869003 RGD
involved in negative regulation of macrophage activation IMP
IMP: Inferred from mutant phenotype
20623539 RGD
involved in negative regulation of nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
18182309 RGD
involved in neuroinflammatory response IDA
IDA: Inferred from direct assay
27235345 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11572871 RGD
involved in positive regulation of amyloid-beta clearance IDA
IDA: Inferred from direct assay
18941241 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17125592 RGD
involved in positive regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
9721086 RGD
involved in positive regulation of eosinophil chemotaxis IDA
IDA: Inferred from direct assay
11071660 RGD
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
18941241 RGD
involved in positive regulation of interleukin-10 production IDA
IDA: Inferred from direct assay
17125592 RGD
involved in positive regulation of mononuclear cell migration IDA
IDA: Inferred from direct assay
11071660 RGD
involved in positive regulation of reactive oxygen species biosynthetic process IDA
IDA: Inferred from direct assay
24073824 RGD
involved in positive regulation of receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
18941241 RGD
involved in regulation of proton transport IDA
IDA: Inferred from direct assay
11739109 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
18231731 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
20116195 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
19608731 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18499367 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18953683 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
23070471 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
18557728 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il4 Protein Structure

IL4_13

IL4_13: smart00190 (0 - 143)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

interleukin-4

  • B-cell IGG differentiation factor

  • B-cell growth factor 1

  • B-cell stimulatory factor 1

  • BSF-1

  • IL-4

  • lymphocyte stimulatory factor 1

Recombinant Il4 Proteins

Cat. No. Product Name Accession Purity
HY-P7101A IL-4 Protein, Rat (CHO, His) P20096 (H23-S147) ≥ 95%, as determined by reducing SDS-PAGE.

Orthologs Information

Species Symbol Source ID
Homo sapiens Il4 NCBI NCBI:3565