2. Gene
  3. Sirt1 - sirtuin 1 Gene

Sirt1 - sirtuin 1 Gene

  • Gene
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Sir2

Gene ID: 309757 | Gene type: protein coding

About Sirt1

Primary_assembly 20: 25,306,917-25,329,260 forward strand.mRatBN7.2:CM026993.1

This gene has 4 transcripts (splice variants), 156 orthologues, 6 paralogues and is associated with 64 phenotypes.

Summary

Enables NAD-dependent histone deacetylase activity and protein kinase B binding activity. Involved in several processes, including cellular response to ketone; negative regulation of apoptotic process; and regulation of peptide hormone secretion. Located in cytosol; growth cone; and nucleus. Used to study middle cerebral artery infarction; obesity; osteoporosis; and type 2 diabetes mellitus. Biomarker of several diseases, including acute kidney failure; artery disease (multiple); impotence; non-alcoholic fatty liver disease; and obesity. Human ortholog(s) of this gene implicated in Huntington's disease and prostate Cancer. Orthologous to human SIRT1 (Sirtuin 1). [provided by Alliance of Genome Resources, Apr 2022]

Sirt1 Products(1)

mRNA Protein Name
NM_001372090.1 NP_001359019.1 NAD-dependent protein deacetylase sirtuin-1

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0150 Nicotinamide Inhibitor 99.87% Yes
HY-B0879A Suramin sodium salt Inhibitor 99.48% Yes
HY-B0879 Suramin Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-123033A Nicotinamide riboside chloride Activator 99.59% Phase 4
HY-123033 Nicotinamide riboside Activator / Phase 4
HY-123033C Nicotinamide riboside malate Activator / Phase 4
HY-123033B Nicotinamide riboside tartrate Activator / Phase 4
Pre-clinical Phase
Bioactive Molecules (45)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10532 SRT 1720 Activator 99.82% Unkown
HY-107454 OSS_128167 Inhibitor 98.63% Unkown
HY-15145 SRT 1720 monohydrochloride Activator 99.92% Unkown
HY-100578 AGK2 Inhibitor 99.62% Unkown
HY-15262 SRT 2104 Activator 99.10% Unkown
HY-13515 Sirtinol Inhibitor ≥98.0% Unkown
HY-101278 Thiomyristoyl Inhibitor 99.74% Unkown
HY-15510 Tenovin-6 Inhibitor 98.33% Unkown
HY-100732 Cambinol Inhibitor 99.89% Unkown
HY-N0704 Agrimol B Activator 99.75% Unkown
HY-124037 SRT 1460 Activator 98.92% Unkown
HY-104073 CAY10602 Activator 98.65% Unkown
HY-15145A SRT 1720 dihydrochloride Activator 99.13% Unkown
HY-15869 Inauhzin Inhibitor 99.49% Unkown
HY-101073 Salermide Inhibitor ≥98.0% Unkown
HY-N0341 Scopolin Activator 99.93% Unkown
HY-136199 SIRT1-IN-1 Inhibitor 98.19% Unkown
HY-15452A (S)-Selisistat Inhibitor 98.15% Unkown
HY-117006 E1231 Activator 98.55% Unkown
HY-146689 SIRT1-IN-2 Inhibitor 98.86% Unkown
HY-16616 SIRT-IN-2 Inhibitor 98.08% Unkown
HY-15510B Tenovin-6 Hydrochloride Inhibitor ≥98.0% Unkown
HY-156781 Sirtuin-1 inhibitor 1 Inhibitor 98.09% Unkown
HY-19634 YK-3-237 Activator 99.59% Unkown
HY-122936 Tanshindiol C Activator 98.47% Unkown
HY-16615 SIRT-IN-1 Inhibitor 98.58% Unkown
HY-151519 SIRT2-IN-9 Inhibitor 99.45% Unkown
HY-N3504 Ophiopogonin D' Activator 99.85% Unkown
HY-111329 JGB1741 Inhibitor 99.05% Unkown
HY-146690 SIRT1-IN-3 Inhibitor 99.18% Unkown
HY-148408 SIRT2-IN-11 Inhibitor 99.94% Unkown
HY-19758A Sirtuin modulator 1 Modulator 99.72% Unkown
HY-111303 CHIC35 Inhibitor / Unkown
HY-156027 SIRT6-IN-3 Inhibitor / Unkown
HY-148312 Sirtuin modulator 4 Inhibitor / Unkown
HY-N9398 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol Activator / Unkown
HY-E70008 Lumbokinase capsules Activator / Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor / Unkown
HY-155784 SPC-180002 Inhibitor / Unkown
HY-148322 Sirtuin modulator 5 Modulator / Unkown
HY-118343 AC-93253 Inhibitor / Unkown
HY-160617 SIRT2-IN-14 Inhibitor / Unkown
HY-N10009 Cudraflavone B Activator / Unkown
HY-146013 Sirt1/2-IN-1 Inhibitor / Unkown
HY-N10125 Ainsliadimer C Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt1 NCBI NCBI:23411