Sirt1 - sirtuin 1 Gene

Also Known as Sir2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 309757

About Sirt1

Primary_assembly 20: 25,306,917-25,329,260 forward strand.mRatBN7.2:CM026993.1

This gene has 4 transcripts (splice variants), 156 orthologues, 6 paralogues and is associated with 64 phenotypes.

Summary

Enables NAD-dependent histone deacetylase activity and protein kinase B binding activity. Involved in several processes, including cellular response to ketone; negative regulation of apoptotic process; and regulation of peptide hormone secretion. Located in cytosol; growth cone; and nucleus. Used to study middle cerebral artery infarction; obesity; osteoporosis; and type 2 diabetes mellitus. Biomarker of several diseases, including acute kidney failure; artery disease (multiple); impotence; non-alcoholic fatty liver disease; and obesity. Human ortholog(s) of this gene implicated in Huntington's disease and prostate Cancer. Orthologous to human SIRT1 (Sirtuin 1). [provided by Alliance of Genome Resources, Apr 2022]

Sirt1 Products (1)

mRNA Protein Name
NM_001372090.1 NP_001359019.1 NAD-dependent protein deacetylase sirtuin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD-dependent histone deacetylase activity IDA
IDA: Inferred from direct assay
19356683 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
19470756 RGD
enables protein kinase B binding IDA
IDA: Inferred from direct assay
23475611 RGD
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16207712 RGD
involved in cellular response to amyloid-beta IEP
IEP: Inferred from expression pattern
23555824 RGD
involved in cellular response to amyloid-beta IMP
IMP: Inferred from mutant phenotype
29358553 RGD
involved in cellular response to antibiotic IEP
IEP: Inferred from expression pattern
17581637 RGD
involved in cellular response to curcumin IEP
IEP: Inferred from expression pattern
24755072 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
17581637 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18538940 RGD
involved in cellular response to resveratrol IMP
IMP: Inferred from mutant phenotype
20089851 RGD
involved in cellular response to rotenone IEP
IEP: Inferred from expression pattern
18538940 RGD
involved in cellular response to vitamin B3 IEP
IEP: Inferred from expression pattern
23555824 RGD
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
20089851 RGD
involved in negative regulation of fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
23479127 RGD
involved in negative regulation of growth hormone secretion IMP
IMP: Inferred from mutant phenotype
23292070 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
24755072 RGD
involved in negative regulation of protein acetylation IMP
IMP: Inferred from mutant phenotype
22044919 RGD
involved in negative regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
22044919 RGD
involved in negative regulation of reactive oxygen species biosynthetic process IMP
IMP: Inferred from mutant phenotype
23422569 RGD
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
19299582 RGD
involved in neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
24183892 RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
25281201 RGD
involved in positive regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
21212096 RGD
involved in positive regulation of heart rate IMP
IMP: Inferred from mutant phenotype
22113495 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
16366736 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
20434449 RGD
involved in positive regulation of protein deacetylation IMP
IMP: Inferred from mutant phenotype
19470756 RGD
involved in positive regulation of skeletal muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
18922599 RGD
involved in positive regulation of thyroid-stimulating hormone secretion IMP
IMP: Inferred from mutant phenotype
20668706 RGD
involved in protein deacetylation IDA
IDA: Inferred from direct assay
19356683 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
27664298 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
24570955 RGD
involved in response to fluoride IEP
IEP: Inferred from expression pattern
24296261 RGD
involved in response to kainic acid IEP
IEP: Inferred from expression pattern
18538940 RGD
involved in response to mycotoxin IEP
IEP: Inferred from expression pattern
18538940 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
15205477 RGD
involved in response to resveratrol IEP
IEP: Inferred from expression pattern
23555824 RGD
involved in vasodilation IMP
IMP: Inferred from mutant phenotype
23826814 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
23475611 RGD
located in growth cone IDA
IDA: Inferred from direct assay
23475611 RGD
located in nucleus IDA
IDA: Inferred from direct assay
20089851 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NAD-dependent protein deacetylase sirtuin-1

  • NAD-dependent deacetylase sirtuin-1

  • NAD-dependent protein deacylase sirtuin-1

  • Sir2alpha

  • sirtuin 1 ((silent mating type information regulation 2, homolog) 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0150 Nicotinamide Inhibitor 99.98% Unkown
HY-B0879A Suramin sodium salt Inhibitor 99.98% Yes
HY-B0879 Suramin Inhibitor / Unkown
HY-B0150A Nicotinamide hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-123033 Nicotinamide riboside Activator / Phase 4
HY-123033A Nicotinamide riboside chloride Activator 99.90% Phase 2
HY-15262 SRT 2104 Activator 99.27% Phase 2

Pre-clinical Phase

Bioactive Molecules (88)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10532 SRT 1720 Activator 99.90% Unkown
HY-113402 Gamma-glutamylcysteine Activator 98.53% Unkown
HY-100578 AGK2 Inhibitor 99.43% Unkown
HY-107454 OSS_128167 Inhibitor 98.92% Unkown
HY-13515 Sirtinol Inhibitor 98.0% Unkown
HY-N0806 Sweroside Activator 99.76% Unkown
HY-N0704 Agrimol B Activator 99.75% Unkown
HY-15145A SRT 1720 dihydrochloride Activator 99.60% Unkown
HY-124037 SRT 1460 Activator 98.16% Unkown
HY-15510 Tenovin-6 Inhibitor 98.00% Unkown
HY-100732 Cambinol Inhibitor 99.89% Unkown
HY-101278 Thiomyristoyl Inhibitor 98.23% Unkown
HY-15145 SRT 1720 monohydrochloride Activator 99.92% Unkown
HY-N0526 2"-O-Galloylhyperin Inhibitor 99.57% Unkown
HY-N0341 Scopolin Activator 99.65% Unkown
HY-15869 Inauhzin Inhibitor 98.46% Unkown
HY-101073 Salermide Inhibitor 98.0% Unkown
HY-16616 SIRT-IN-2 Inhibitor 95.57% Unkown
HY-19759 SRT 2183 Activator 98.06% Unkown
HY-136199 SIRT1-IN-1 Inhibitor 98.15% Unkown
HY-103721 SIRT6-IN-2 Inhibitor 99.92% Unkown
HY-P5247 Palmitoyl tetrapeptide-20 Activator 99.21% Unkown
HY-118020A Loliolide Activator 99.92% Unkown
HY-107245 Segetalin B Activator 99.9% Unkown
HY-114557 NSC 90469 Inhibitor 99.41% Unkown
HY-104073 CAY10602 Activator 98.69% Unkown
HY-16605 SIRT6-IN-6 Inhibitor 98.59% Unkown
HY-N2787 8-​Prenylnaringenin Activator 99.63% Unkown
HY-N1926 Dihydrocoumarin Inhibitor 99.81% Unkown
HY-N0859 Schisanhenol Inhibitor 99.99% Unkown
HY-15510B Tenovin-6 Hydrochloride Inhibitor 98.88% Unkown
HY-W009300 4-Hydroxyestrone ≥99.0% Unkown
HY-E70008 Lumbokinase Activator / Unkown
HY-124452 Nocardamine Inhibitor 99.06% Unkown
HY-169934 SIRT1-IN-4 Inhibitor 98.62% Unkown
HY-19758A Sirtuin modulator 1 Modulator 99.85% Unkown
HY-124113 4'-Bromo-resveratrol Inhibitor 99.94% Unkown
HY-15452A (S)-Selisistat Inhibitor 99.39% Unkown
HY-123033C Nicotinamide riboside malate Activator 98.04% Yes
HY-117006 E1231 Activator 98.46% Unkown
HY-N3504 Ophiopogonin D' Activator 99.94% Unkown
HY-156027 SIRT6-IN-3 Inhibitor 98.19% Unkown
HY-16615 SIRT-IN-1 Inhibitor 98.14% Unkown
HY-146690 SIRT1-IN-3 Inhibitor 99.12% Unkown
HY-111329 JGB1741 Inhibitor 99.37% Unkown
HY-146689 SIRT1-IN-2 Inhibitor 98.31% Unkown
HY-N3225 Myricanol Activator 98.93% Unkown
HY-122936 Tanshindiol C Activator 98.47% Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor 98.37% Unkown
HY-123033B Nicotinamide riboside tartrate Activator 98.07% Yes
HY-156781 Sirtuin-1 inhibitor 1 Inhibitor 98.09% Unkown
HY-156023 SIRT1 activator 2 Activator 99.28% Unkown
HY-118343 AC-93253 Inhibitor 99.3% Unkown
HY-19634 YK-3-237 Activator 99.54% Unkown
HY-P5247A Palmitoyl tetrapeptide-20 TFA Activator / Unkown
HY-151519 SIRT2-IN-9 Inhibitor 99.45% Unkown
HY-N12378 β-Patchoulene Activator 96.88% Unkown
HY-148408 SIRT2-IN-11 Inhibitor 99.94% Unkown
HY-P3364A Ac-QPKK(Ac)-AMC acetate Substrate 99.38% Unkown
HY-111303 CHIC35 Inhibitor / Unkown
HY-184899 Sirt1/CXCR3-IN-1 Inhibitor / Unkown
HY-N18386 Altissimacoumarin F Activator / Unkown
HY-123241 ZINC08792229 Inhibitor / Unkown
HY-114906 SIRT1/2/3-IN-2 Inhibitor / Unkown
HY-N10009 Cudraflavone B Activator / Unkown
HY-139125 DCHC Activator / Unkown
HY-114510 PRMT/HKMT-IN-1 / Unkown
HY-182412 NH4-6 Inhibitor / Unkown
HY-N18048 Gypenoside CII Control / Unkown
HY-160617 SIRT2-IN-14 Inhibitor / Unkown
HY-148322 Sirtuin modulator 5 Modulator / Unkown
HY-148312 Sirtuin modulator 4 Inhibitor / Unkown
HY-N17821 Butrin Inhibitor / Unkown
HY-153509 Sirtuin-IN-1 Inhibitor / Unkown
HY-183044 SIRT1 activator 4 Activator / Unkown
HY-136713 Sirt1/2-IN-5 Inhibitor / Unkown
HY-146013 Sirt1/2-IN-1 Inhibitor / Unkown
HY-138443A BF-175 Agonist / Unkown
HY-184372 SIRT1-IN-7 Inhibitor / Unkown
HY-170402 SIRT6-IN-4 Inhibitor / Unkown
HY-155784 SPC-180002 Inhibitor / Unkown
HY-169809 SIRT1-IN-5 Inhibitor / Unkown
HY-160944 hsa62 Inhibitor / Unkown
HY-N9398 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol Activator / Unkown
HY-W109401 SIRT-IN-6 Inhibitor / Unkown
HY-183853 Arecaidine-propargyl ester Activator / Unkown
HY-N11262 Sudachitin Activator / Unkown
HY-187137 2-(2-Thienyl)benzofuran Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt1 NCBI NCBI:23411