SIRT1 - sirtuin 1 Gene

Also Known as SIR2; SIR2L1; SIR2alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23411

About SIRT1

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:67,884,656-67,918,390 (from NCBI)

This gene has 6 transcripts (splice variants), 156 orthologues and 6 paralogues. Ubiquitous expression in adrenal (RPKM 17.4), testis (RPKM 16.6) and 25 other tissues.

Summary

This gene encodes a member of the Sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast Sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the Sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

SIRT1 Products (3)

mRNA	Protein	Name
NM_001142498.2	NP_001135970.1	NAD-dependent protein deacetylase sirtuin-1 isoform b
NM_001314049.1	NP_001300978.1	NAD-dependent protein deacetylase sirtuin-1 isoform c
NM_012238.5	NP_036370.2	NAD-dependent protein deacetylase sirtuin-1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	20955178	GOA
enables HLH domain binding	IPI IPI: Inferred from physical interaction	12535671	GOA
enables NAD-dependent histone H3K14 deacetylase activity	IDA IDA: Inferred from direct assay	15469825	GOA
enables NAD-dependent histone H3K9 deacetylase activity	IDA IDA: Inferred from direct assay	15469825	GOA
enables NAD-dependent histone H4K16 deacetylase activity	IDA IDA: Inferred from direct assay	15469825	GOA
enables NAD-dependent histone deacetylase activity	IDA IDA: Inferred from direct assay	12006491	GOA
enables NAD-dependent histone decrotonylase activity	IDA IDA: Inferred from direct assay	28497810	GOA
enables NAD-dependent protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	15692560	GOA
enables NAD-dependent protein lysine deacetylase activity	IMP IMP: Inferred from mutant phenotype	11672523	GOA
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	12535671	GOA
enables deacetylase activity	IDA IDA: Inferred from direct assay	18203716	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23382074	GOA
enables histone H3K deacetylase activity	IDA IDA: Inferred from direct assay	20027304	GOA
enables histone H4K12 deacetylase activity	IDA IDA: Inferred from direct assay	15469825	GOA
enables histone binding	IPI IPI: Inferred from physical interaction	15469825	GOA
enables histone deacetylase activity	EXP EXP: Inferred from Experiment	18485871	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15469825	GOA
enables keratin filament binding	IPI IPI: Inferred from physical interaction	23382074	GOA
enables mitogen-activated protein kinase binding	IPI IPI: Inferred from physical interaction	20027304	GOA
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	24043310	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	11672523	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11672523	GOA
enables protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	19934257	GOA
enables protein lysine deacetylase activity	IMP IMP: Inferred from mutant phenotype	20203304	GOA
enables protein lysine delactylase activity	IDA IDA: Inferred from direct assay	38512451	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	12535671	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	17505061	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	18203716	GOA
involved in DNA repair-dependent chromatin remodeling	IDA IDA: Inferred from direct assay	20100829	GOA
involved in UV-damage excision repair	IMP IMP: Inferred from mutant phenotype	20670893	GOA
involved in angiogenesis	IDA IDA: Inferred from direct assay	20620956	GOA
involved in cellular response to glucose starvation	IMP IMP: Inferred from mutant phenotype	18485871	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	20027304	GOA
involved in cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	20620956	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	15152190	GOA
involved in chromatin organization	IMP IMP: Inferred from mutant phenotype	22956909	GOA
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18662546	GOA
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	18485871	GOA
involved in heterochromatin formation	IDA IDA: Inferred from direct assay	15469825	GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	20100829	GOA
involved in maintenance of nucleus location	IDA IDA: Inferred from direct assay	15692560	GOA
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	11672523	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11672523	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11672523	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18485871	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	15152190	GOA
involved in negative regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	20169165	GOA
involved in negative regulation of androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17505061	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16892051	GOA
involved in negative regulation of attachment of mitotic spindle microtubules to kinetochore	IDA IDA: Inferred from direct assay	30409912	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	17680780	GOA
involved in negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	18485871	GOA
involved in negative regulation of cellular response to testosterone stimulus	IMP IMP: Inferred from mutant phenotype	17505061	GOA
involved in negative regulation of cellular senescence	IDA IDA: Inferred from direct assay	20203304	GOA
involved in negative regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	20424141	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17916362	GOA
involved in negative regulation of helicase activity	IDA IDA: Inferred from direct assay	18203716	GOA
involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	17317627	GOA
involved in negative regulation of peptidyl-lysine acetylation	IDA IDA: Inferred from direct assay	20100829	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	21149730	GOA
involved in negative regulation of phosphorylation	IMP IMP: Inferred from mutant phenotype	17612497	GOA
involved in negative regulation of protein acetylation	IMP IMP: Inferred from mutant phenotype	17916362	GOA
involved in negative regulation of signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	29681526	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12535671	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17505061	GOA
involved in negative regulation of triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	29765047	GOA
involved in peptidyl-lysine acetylation	IMP IMP: Inferred from mutant phenotype	18004385	GOA
involved in positive regulation of DNA repair	IMP IMP: Inferred from mutant phenotype	19934257	GOA
involved in positive regulation of MHC class II biosynthetic process	IDA IDA: Inferred from direct assay	21890893	GOA
involved in positive regulation of adaptive immune response	IDA IDA: Inferred from direct assay	21890893	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	23960241	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	20424141	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	15152190	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19047049	GOA
involved in positive regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	23960241	GOA
involved in positive regulation of cAMP-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	18687677	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21807113	GOA
involved in positive regulation of cellular senescence	IDA IDA: Inferred from direct assay	18687677	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	19047049	GOA
involved in positive regulation of double-strand break repair	IDA IDA: Inferred from direct assay	32538779	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	20203304	GOA
involved in positive regulation of gluconeogenesis	IDA IDA: Inferred from direct assay	15692560	GOA
involved in positive regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	21241768	GOA
involved in positive regulation of macroautophagy	IDA IDA: Inferred from direct assay	18296641	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	20203304	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12837246	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	21841822	GOA
involved in protein deacetylation	IDA IDA: Inferred from direct assay	18203716	GOA
involved in protein deacetylation	IMP IMP: Inferred from mutant phenotype	11672523	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	21841822	GOA
involved in pyrimidine dimer repair by nucleotide-excision repair	IMP IMP: Inferred from mutant phenotype	21149730	GOA
involved in rDNA heterochromatin formation	IDA IDA: Inferred from direct assay	18485871	GOA
involved in rDNA heterochromatin formation	IMP IMP: Inferred from mutant phenotype	18485871	GOA
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19934257	GOA
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12006491	GOA
involved in regulation of centrosome duplication	IDA IDA: Inferred from direct assay	31722219	GOA
involved in regulation of endodeoxyribonuclease activity	IMP IMP: Inferred from mutant phenotype	19934257	GOA
involved in regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	15692560	GOA
involved in regulation of transcription by glucose	IMP IMP: Inferred from mutant phenotype	18485871	GOA
involved in response to hydrogen peroxide	IDA IDA: Inferred from direct assay	19934257	GOA
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	14976264	GOA
involved in single strand break repair	IMP IMP: Inferred from mutant phenotype	20097625	GOA
involved in stress-induced premature senescence	IMP IMP: Inferred from mutant phenotype	17916362	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	23960241	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	15684044	GOA
located in PML body	IDA IDA: Inferred from direct assay	12006491	GOA
located in chromatin	IDA IDA: Inferred from direct assay	17505061	GOA
part of chromatin silencing complex	IDA IDA: Inferred from direct assay	18485871	GOA
NOT located in cytoplasm	IDA IDA: Inferred from direct assay	15469825	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20027304	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	20027304	GOA
part of eNoSc complex	IPI IPI: Inferred from physical interaction	18485871	GOA
located in euchromatin	IDA IDA: Inferred from direct assay	15469825	GOA
located in heterochromatin	IDA IDA: Inferred from direct assay	15469825	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	15469825	GOA
located in nuclear inner membrane	IDA IDA: Inferred from direct assay	15469825	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	16079181	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	15469825	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	16079181	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11672523	GOA
located in rDNA heterochromatin	IDA IDA: Inferred from direct assay	18485871	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRT1 Protein Structure

SIR2

0
200
400
600
747 a.a.

Protein Preferred Names	Protein Names
NAD-dependent protein deacetylase sirtuin-1	NAD-dependent protein deacylase sirtuin-1 SIR2-like protein 1 regulatory protein SIR2 homolog 1 sirtuin type 1

SIRT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SIRT1	Q96EB6	APEX1	Homo sapiens	P27695	Deacetylase Assay	19934257
Intra	SIRT1	Q96EB6	APEX1	Homo sapiens	P27695	IF	19934257
Intra	SIRT1	Q96EB6	IRS2	Homo sapiens	Q9Y4H2	Anti Bait CoIP	21241768
Intra	SIRT1	Q96EB6	IRS2	Homo sapiens	Q9Y4H2	Anti Bait CoIP	17901049
Intra	SIRT1	Q96EB6	FOXO1	Homo sapiens	Q12778	Anti Tag CoIP	15692560
Intra	SIRT1	Q96EB6	FOXO1	Homo sapiens	Q12778	Anti Tag CoIP	18235501
Intra	SIRT1	Q96EB6	SETD7	Homo sapiens	Q8WTS6	Anti Bait CoIP	21245319
Cross	SIRT1	Q96EB6	Foxo1	Mus musculus	Q9R1E0	Anti Tag CoIP	22510882
Intra	SIRT1	Q96EB6	MECOM	Homo sapiens	Q03112	Anti Bait CoIP	21555002
Intra	SIRT1	Q96EB6	CIITA	Homo sapiens	P33076	Anti Bait CoIP	21890893
Intra	SIRT1	Q96EB6	RPTOR	Homo sapiens	Q8N122	Anti Bait CoIP	21471201
Intra	SIRT1	Q96EB6	FOXO3	Homo sapiens	O43524	Anti Bait CoIP	15126506
Intra	SIRT1	Q96EB6	FOXO3	Homo sapiens	O43524	Deacetylase Assay	14976264
Intra	SIRT1	Q96EB6	FOXO3	Homo sapiens	O43524	Anti Tag CoIP	14976264
Intra	SIRT1	Q96EB6	CSAG2	Homo sapiens	Q9Y5P2	Anti Tag CoIP	32761762
Intra	SIRT1	Q96EB6	CSAG2	Homo sapiens	Q9Y5P2	Pull Down	32761762
Intra	SIRT1	Q96EB6	CSAG2	Homo sapiens	Q9Y5P2	Enzymatic Study	32761762
Intra	SIRT1	Q96EB6	HES1	Homo sapiens	Q14469	Pull Down	12535671
Intra	SIRT1	Q96EB6	XPA	Homo sapiens	P23025	Anti Tag CoIP	20670893
Intra	SIRT1	Q96EB6	XPA	Homo sapiens	P23025	Anti Bait CoIP	20670893
Intra	SIRT1	Q96EB6	AKT1	Homo sapiens	P31749	Anti Bait CoIP	21775285
Intra	SIRT1	Q96EB6	AKT1	Homo sapiens	P31749	Pull Down	21775285
Intra	SIRT1	Q96EB6	CSNK2A1	Homo sapiens	P68400	Anti Bait CoIP	21968188
Intra	SIRT1	Q96EB6	CSNK2A1	Homo sapiens	P68400	Anti Bait CoIP	19680552
Intra	SIRT1	Q96EB6	CSNK2A1	Homo sapiens	P68400	Anti Bait CoIP	20439735
Intra	SIRT1	Q96EB6	CSNK2B	Homo sapiens	P67870	Y2H	21968188
Intra	SIRT1	Q96EB6	CSNK2B	Homo sapiens	P67870	Anti Bait CoIP	21968188
Intra	SIRT1	Q96EB6	CSNK2B	Homo sapiens	P67870	Pull Down	21968188
Cross	SIRT1	Q96EB6	Ncor1	Mus musculus	Q60974	Pull Down	15175761
Intra	SIRT1	Q96EB6	SUV39H1	Homo sapiens	O43463	Deacetylase Assay	18004385
Intra	SIRT1	Q96EB6	SUV39H1	Homo sapiens	O43463	Anti Tag CoIP	18004385
Intra	SIRT1	Q96EB6	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	17334224
Intra	SIRT1	Q96EB6	XRCC6	Homo sapiens	P12956	Deacetylase Assay	15205477
Intra	SIRT1	Q96EB6	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	15205477
Intra	SIRT1	Q96EB6	CCAR2	Homo sapiens	Q8N163	Pull Down	18235501
Intra	SIRT1	Q96EB6	CCAR2	Homo sapiens	Q8N163	Anti Tag CoIP	18235502
Intra	SIRT1	Q96EB6	CCAR2	Homo sapiens	Q8N163	Pull Down	18235502
Intra	SIRT1	Q96EB6	CCAR2	Homo sapiens	Q8N163	Anti Bait CoIP	18235502
Intra	SIRT1	Q96EB6	CCAR2	Homo sapiens	Q8N163	GMS	18235502
Intra	SIRT1	Q96EB6	CCAR2	Homo sapiens	Q8N163	Anti Tag CoIP	18235501
Intra	SIRT1	Q96EB6	CCAR2	Homo sapiens	Q8N163	Anti Bait CoIP	18235501
Intra	SIRT1	Q96EB6	MTOR	Homo sapiens	P42345	Anti Bait CoIP	21471201
Intra	SIRT1	Q96EB6	MTOR	Homo sapiens	P42345	Protein Kinase Assay	21471201
Intra	SIRT1	Q96EB6	TP53	Homo sapiens	P04637	Acetylase Assay	18235502
Intra	SIRT1	Q96EB6	TP53	Homo sapiens	P04637	Anti Bait CoIP	11672523
Intra	SIRT1	Q96EB6	TP53	Homo sapiens	P04637	Anti Tag CoIP	18235502
Intra	SIRT1	Q96EB6	TP53	Homo sapiens	P04637	Anti Bait CoIP	12006491
Intra	SIRT1	Q96EB6	TP53	Homo sapiens	P04637	Anti Bait CoIP	21245319
Intra	SIRT1	Q96EB6	TP53	Homo sapiens	P04637	Enzymatic Study	32761762
Intra	SIRT1	Q96EB6	TP53	Homo sapiens	P04637	Deacetylase Assay	18235501
Intra	SIRT1	Q96EB6	TP53	Homo sapiens	P04637	Anti Tag CoIP	18235501
Intra	SIRT1	Q96EB6	TP53	Homo sapiens	P04637	Deacetylase Assay	17964266
Intra	SIRT1	Q96EB6	WRN	Homo sapiens	Q14191	Anti Tag CoIP	19343720
Intra	SIRT1	Q96EB6	WRN	Homo sapiens	Q14191	Pull Down	18203716
Intra	SIRT1	Q96EB6	WRN	Homo sapiens	Q14191	Pull Down	19343720
Intra	SIRT1	Q96EB6	MAP1LC3B	Homo sapiens	Q9GZQ8	Deacetylase Assay	18296641
Intra	SIRT1	Q96EB6	MAP1LC3B	Homo sapiens	Q9GZQ8	Anti Tag CoIP	18296641
Intra	SIRT1	Q96EB6	TP73	Homo sapiens	O15350	Anti Tag CoIP	16998810
Intra	SIRT1	Q96EB6	NR0B2	Homo sapiens	Q15466	Anti Tag CoIP	20375098
Intra	SIRT1	Q96EB6	NR0B2	Homo sapiens	Q15466	Anti Bait CoIP	20375098
Intra	SIRT1	Q96EB6	NR0B2	Homo sapiens	Q15466	Pull Down	20375098
Intra	SIRT1	Q96EB6	NMNAT1	Homo sapiens	Q9HAN9	Pull Down	19478080
Intra	SIRT1	Q96EB6	HCFC1	Homo sapiens	P51610	Anti Tag CoIP	21909281
Intra	SIRT1	Q96EB6	TSC2	Homo sapiens	P49815	Anti Bait CoIP	20169165
Intra	SIRT1	Q96EB6	RARA	Homo sapiens	P10276	Pull Down	19934264
Intra	SIRT1	Q96EB6	EP300	Homo sapiens	Q09472	Anti Bait CoIP	19047049
Intra	SIRT1	Q96EB6	EP300	Homo sapiens	Q09472	CH-IP	20660480
Intra	SIRT1	Q96EB6	MYC	Homo sapiens	P01106	Deacetylase Assay	21807113
Intra	SIRT1	Q96EB6	MYC	Homo sapiens	P01106	Anti Tag CoIP	21807113
Intra	SIRT1	Q96EB6	RPS19BP1	Homo sapiens	Q86WX3	Anti Bait CoIP	17964266
Intra	SIRT1	Q96EB6	RPS19BP1	Homo sapiens	Q86WX3	Pull Down	17964266
Intra	SIRT1	Q96EB6	RPS19BP1	Homo sapiens	Q86WX3	Y2H	17964266
Intra	SIRT1	Q96EB6	FOXO4	Homo sapiens	P98177	Deacetylase Assay	15126506
Intra	SIRT1	Q96EB6	E2F1	Homo sapiens	Q01094	Anti Bait CoIP	19188449
Intra	SIRT1	Q96EB6	E2F1	Homo sapiens	Q01094	Pull Down	16892051
Intra	SIRT1	Q96EB6	KAT2B	Homo sapiens	Q92831	Deacetylase Assay	19188449
Intra	SIRT1	Q96EB6	KAT2B	Homo sapiens	Q92831	Anti Bait CoIP	19188449
Intra	SIRT1	Q96EB6	NBN	Homo sapiens	O60934	Pull Down	17612497
Intra	SIRT1	Q96EB6	NBN	Homo sapiens	O60934	Anti Bait CoIP	17612497
Intra	SIRT1	Q96EB6	NBN	Homo sapiens	O60934	Anti Tag CoIP	17612497
Cross	SIRT1	Q96EB6	Pparg	Mus musculus	P37238	Anti Tag CoIP	22863012
Cross	SIRT1	Q96EB6	Nr1h3	Mus musculus	Q9Z0Y9	Anti Tag CoIP	17936707
Intra	SIRT1	Q96EB6	NHLH2	Homo sapiens	Q02577	Anti Tag CoIP	22169038
Cross	SIRT1	Q96EB6	Pparg	Mus musculus	P37238-1	Deacetylase Assay	22863012
Cross	SIRT1	Q96EB6	Pparg	Mus musculus	P37238-1	Anti Tag CoIP	22863012
Intra	SIRT1	Q96EB6	SNW1	Homo sapiens	Q13573	IF	19934264
Intra	SIRT1	Q96EB6	SNW1	Homo sapiens	Q13573	Pull Down	19934264
Intra	SIRT1	Q96EB6	SNW1	Homo sapiens	Q13573	Y2H	19934264
Intra	SIRT1	Q96EB6	FHL2	Homo sapiens	Q14192	Anti Tag CoIP	15692560
Intra	SIRT1	Q96EB6	TLE1	Homo sapiens	Q04724	Y2H	17680780
Intra	SIRT1	Q96EB6	ACACA	Homo sapiens	Q13085	Pull Down	19343720
Intra	SIRT1	Q96EB6	ACACA	Homo sapiens	Q13085	Anti Tag CoIP	19343720
Intra	SIRT1	Q96EB6	DNMT1	Homo sapiens	P26358	Imaging	21947282
Intra	SIRT1	Q96EB6	DNMT1	Homo sapiens	P26358	Anti Bait CoIP	22094255
Intra	SIRT1	Q96EB6	DNMT1	Homo sapiens	P26358	Deacetylase Assay	21947282
Intra	SIRT1	Q96EB6	DNMT1	Homo sapiens	P26358	Anti Bait CoIP	21947282
Intra	SIRT1	Q96EB6	DNMT1	Homo sapiens	P26358	Anti Tag CoIP	21947282
Intra	SIRT1	Q96EB6	DVL1	Homo sapiens	O14640	Anti Bait CoIP	20439735
Intra	SIRT1	Q96EB6	RELA	Homo sapiens	Q04206	Anti Bait CoIP	15152190
Intra	SIRT1	Q96EB6	RELA	Homo sapiens	Q04206	Anti Tag CoIP	15152190
Intra	SIRT1	Q96EB6	DVL3	Homo sapiens	Q92997	Anti Bait CoIP	20439735
Intra	SIRT1	Q96EB6	DVL3	Homo sapiens	Q92997	Anti Tag CoIP	20439735
Intra	SIRT1	Q96EB6	PPARG	Homo sapiens	P37231	Pull Down	20660480
Intra	SIRT1	Q96EB6	PPARG	Homo sapiens	P37231	CH-IP	20660480
Intra	SIRT1	Q96EB6	PPARG	Homo sapiens	P37231	Anti Tag CoIP	20660480
Intra	SIRT1	Q96EB6	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	21241768
Intra	SIRT1	Q96EB6	MYCN	Homo sapiens	P04198	Anti Bait CoIP	21698133
Intra	SIRT1	Q96EB6	SREBF1	Homo sapiens	P36956-3	Deacetylase Assay	20817729
Intra	SIRT1	Q96EB6	SREBF1	Homo sapiens	P36956-3	Pull Down	20817729
Intra	SIRT1	Q96EB6	ATG7	Homo sapiens	O95352	Deacetylase Assay	18296641
Intra	SIRT1	Q96EB6	ATG7	Homo sapiens	O95352	Anti Tag CoIP	18296641

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIRT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71596	SIRT1 Protein, Human (His)	Q96EB6-1 (A2-S747)	≥ 90%, as determined by reducing SDS-PAGE.

SIRT1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80319	SIRT1 Antibody (YA082)	WB, IHC-P, ICC/IF, ChIP	Human, Mouse
HY-P81303	Phospho-SIRT1 (Ser47) Antibody (YA1036)	WB, IHC-P, ICC/IF	Human
HY-P81303A	Phospho-SIRT1 (Thr530) Antibody (YA1037)	WB	Human
HY-P84728	SIRT1 Antibody (YA4425)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
HY-P84728A	SIRT1 Antibody (YA4425)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
HY-P86635	SIRT1 Antibody (YA6327)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Osteonecrosis Of The Jaw
Aging
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability
Diabetic Encephalopathy
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Pulpitis	Pulp Stones Pulpitis Nos
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Non-Alcoholic Steatohepatitis	Nonalcoholic Steatohepatitis Nash Nash - [Non-Alcoholic Steatohepatitis] Non-Alcoholic Steatohepatosis
Myopathy	Muscular Diseases Myopathies
Acquired Metabolic Disease
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Overnutrition
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases Cardiovascular Disease
Werner Syndrome	Werner'S Syndrome WRN Adult Progeria Ws Adult Premature Ageing Syndrome Adult Premature Aging Syndrome Werners Syndrome
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Periapical Periodontitis	Apical Periodontitis Periodontitis Apical
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Inclusion Body Myositis	Ibm Sporadic Inclusion Body Myositis Myositis, Inclusion Body Inflammatory Myopathy Inflammatory Myopathies Sibm Myositis Inclusion Body Nonaka Myopathy Inclusion Body Myopathy, Autosomal Recessive Inclusion Body Myopathy, Autosomal Dominant Myositis Inclusion Body Myopathy, Sporadic
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Diabetes Mellitus	Diabetes
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Hyperphosphatemia
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Laron Syndrome	Growth Hormone Insensitivity Syndrome Growth Hormone Receptor Deficiency Laron Dwarfism Pituitary Dwarfism Ii Laron-Type Isolated Somatotropin Defect Primary Growth Hormone Resistance Laron-Type Dwarfism Laron Type Pituitary Dwarfism I Primary Growth Hormone Insensitivity Primary Gh Resistance Gh-R Deficiency Growth Hormone Receptor Defect Laron-Type Pituitary Dwarfism Laron-Type Short Stature Severe Gh Insensitivity Ghis Short Stature Due To A Defect In Growth Hormone Receptor Or Post-Receptor Pathway Complete Growth Hormone Insensitivity Gh Receptor Deficiency Primary Gh Insensitivity Short Stature Due To Growth Hormone Resistance LARS
Middle East Respiratory Syndrome	Mers Mers - [Middle East Respiratory Syndrome]
Myositis	Idiopathic Inflammatory Myopathy Idiopathic Inflammatory Myositis Iim Imm Idiopathic Inflammatory Myopathies Myopathy, Familial Idiopathic Inflammatory Inflammatory Disorder Of Muscle Idiopathic Inflammatory Myopathy, Familial Inflammatory Myopathy, Idiopathic Myopathies Idiopathic Inflammatory Familial Idiopathic Inflammatory Myopathy
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Lipomatosis	Benign Symmetrical Lipomatosis
Lipid Storage Disease	Lipoidosis Inborn Lipid Storage Disorder Lipoid Storage Diseas Lipid Storage Diseases Lipidoses
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0150	Nicotinamide	Inhibitor	99.98%	Unkown
HY-B0879A	Suramin sodium salt	Inhibitor	99.98%	Yes
HY-B0879	Suramin	Inhibitor	/	Unkown
HY-B0150A	Nicotinamide hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-123033	Nicotinamide riboside	Activator	/	Phase 4
HY-123033A	Nicotinamide riboside chloride	Activator	99.90%	Phase 2
HY-15262	SRT 2104	Activator	99.27%	Phase 2

Pre-clinical Phase

Bioactive Molecules (85)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10532	SRT 1720	Activator	99.90%	Unkown
HY-113402	Gamma-glutamylcysteine	Activator	98.53%	Unkown
HY-100578	AGK2	Inhibitor	99.43%	Unkown
HY-107454	OSS_128167	Inhibitor	98.92%	Unkown
HY-13515	Sirtinol	Inhibitor	98.0%	Unkown
HY-N0806	Sweroside	Activator	99.76%	Unkown
HY-N0704	Agrimol B	Activator	99.75%	Unkown
HY-15145A	SRT 1720 dihydrochloride	Activator	99.60%	Unkown
HY-124037	SRT 1460	Activator	98.16%	Unkown
HY-15510	Tenovin-6	Inhibitor	98.00%	Unkown
HY-100732	Cambinol	Inhibitor	99.89%	Unkown
HY-101278	Thiomyristoyl	Inhibitor	98.23%	Unkown
HY-15145	SRT 1720 monohydrochloride	Activator	99.92%	Unkown
HY-N0526	2"-O-Galloylhyperin	Inhibitor	99.57%	Unkown
HY-N0341	Scopolin	Activator	99.65%	Unkown
HY-15869	Inauhzin	Inhibitor	98.46%	Unkown
HY-101073	Salermide	Inhibitor	98.0%	Unkown
HY-16616	SIRT-IN-2	Inhibitor	98.08%	Unkown
HY-136199	SIRT1-IN-1	Inhibitor	98.15%	Unkown
HY-19759	SRT 2183	Activator	98.06%	Unkown
HY-103721	SIRT6-IN-2	Inhibitor	99.92%	Unkown
HY-P5247	Palmitoyl tetrapeptide-20	Activator	99.21%	Unkown
HY-118020A	Loliolide	Activator	99.92%	Unkown
HY-107245	Segetalin B	Activator	99.9%	Unkown
HY-114557	NSC 90469	Inhibitor	99.41%	Unkown
HY-104073	CAY10602	Activator	98.69%	Unkown
HY-16605	SIRT6-IN-6	Inhibitor	98.59%	Unkown
HY-N2787	8-Prenylnaringenin	Activator	99.63%	Unkown
HY-N0859	Schisanhenol	Inhibitor	99.99%	Unkown
HY-N1926	Dihydrocoumarin	Inhibitor	99.81%	Unkown
HY-15510B	Tenovin-6 Hydrochloride	Inhibitor	98.88%	Unkown
HY-W009300	4-Hydroxyestrone		≥99.0%	Unkown
HY-E70008	Lumbokinase	Activator	/	Unkown
HY-169934	SIRT1-IN-4	Inhibitor	98.62%	Unkown
HY-19758A	Sirtuin modulator 1	Modulator	99.85%	Unkown
HY-124113	4'-Bromo-resveratrol	Inhibitor	99.94%	Unkown
HY-15452A	(S)-Selisistat	Inhibitor	99.39%	Unkown
HY-123033C	Nicotinamide riboside malate	Activator	98.04%	Yes
HY-117006	E1231	Activator	98.46%	Unkown
HY-N3504	Ophiopogonin D'	Activator	99.94%	Unkown
HY-156027	SIRT6-IN-3	Inhibitor	98.19%	Unkown
HY-16615	SIRT-IN-1	Inhibitor	98.14%	Unkown
HY-111329	JGB1741	Inhibitor	99.37%	Unkown
HY-N3225	Myricanol	Activator	98.93%	Unkown
HY-146689	SIRT1-IN-2	Inhibitor	98.31%	Unkown
HY-146690	SIRT1-IN-3	Inhibitor	99.12%	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	98.37%	Unkown
HY-122936	Tanshindiol C	Activator	98.47%	Unkown
HY-123033B	Nicotinamide riboside tartrate	Activator	98.07%	Yes
HY-156781	Sirtuin-1 inhibitor 1	Inhibitor	98.09%	Unkown
HY-118343	AC-93253	Inhibitor	99.3%	Unkown
HY-19634	YK-3-237	Activator	99.54%	Unkown
HY-P5247A	Palmitoyl tetrapeptide-20 TFA	Activator	/	Unkown
HY-151519	SIRT2-IN-9	Inhibitor	99.45%	Unkown
HY-N12378	β-Patchoulene	Activator	96.88%	Unkown
HY-156023	SIRT1 activator 2	Activator	99.28%	Unkown
HY-148408	SIRT2-IN-11	Inhibitor	99.94%	Unkown
HY-P3364A	Ac-QPKK(Ac)-AMC acetate	Substrate	99.38%	Unkown
HY-111303	CHIC35	Inhibitor	/	Unkown
HY-148322	Sirtuin modulator 5	Modulator	/	Unkown
HY-148312	Sirtuin modulator 4	Inhibitor	/	Unkown
HY-114906	SIRT1/2/3-IN-2	Inhibitor	/	Unkown
HY-153509	Sirtuin-IN-1	Inhibitor	/	Unkown
HY-183044	SIRT1 activator 4	Activator	/	Unkown
HY-146013	Sirt1/2-IN-1	Inhibitor	/	Unkown
HY-139125	DCHC	Activator	/	Unkown
HY-182412	NH4-6	Inhibitor	/	Unkown
HY-114510	PRMT/HKMT-IN-1		/	Unkown
HY-169809	SIRT1-IN-5	Inhibitor	/	Unkown
HY-N18386	Altissimacoumarin F	Activator	/	Unkown
HY-136713	Sirt1/2-IN-5	Inhibitor	/	Unkown
HY-N17821	Butrin	Inhibitor	/	Unkown
HY-123241	ZINC08792229	Inhibitor	/	Unkown
HY-N10009	Cudraflavone B	Activator	/	Unkown
HY-138443A	BF-175	Agonist	/	Unkown
HY-184372	SIRT1-IN-7	Inhibitor	/	Unkown
HY-155784	SPC-180002	Inhibitor	/	Unkown
HY-N18048	Gypenoside CII	Control	/	Unkown
HY-160944	hsa62	Inhibitor	/	Unkown
HY-160617	SIRT2-IN-14	Inhibitor	/	Unkown
HY-170402	SIRT6-IN-4	Inhibitor	/	Unkown
HY-N9398	3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol	Activator	/	Unkown
HY-183853	Arecaidine-propargyl ester	Activator	/	Unkown
HY-N11262	Sudachitin	Activator	/	Unkown
HY-W109401	SIRT-IN-6	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SIRT1	VGNC	VGNC:77233
Mus musculus	SIRT1	MGD	MGI:2135607
Bos taurus	SIRT1	VGNC	VGNC:34630
Felis catus	SIRT1	VGNC	VGNC:65155
Rattus norvegicus	SIRT1	RGD	RGD:1308542
Canis familiaris	SIRT1	VGNC	VGNC:46183
Others	SIRT1	NCBI