Dracorhodin
Based on 2 publication(s) in Google Scholar
Dracorhodin is a natural product that can be obtained from the natural active molecule Dragon's blood. Dracorhodin inhibits PI3K/Akt and NF-κB activation, upregulates p53 expression, activates caspase, produces ROS, and promotes Apoptosis. Dracorhodin regulates the TLR4. Dracorhodin promotes wound healing, improves diabetes. Dracorhodin has anti-tumor activity against prostate cancer, breast cancer, cervical cancer and other cancers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 96.76%
- CAS 番号: 643-56-1
- 分子式: C17H14O3
- 分子量:266.29
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Dracorhodin
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生物活性
製品説明
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TLR4 |
Caspase 3 |
体外実験
Dracorhodin (0-80 μM; 12-48 h) inhibits the growth of human cervical cancer HeLa cells, human malignant melanoma A375-S2 cells, human breast cancer MCF-7 cells and human histiocytic lymphoma U937 cells in a dose-and time-dependent manner[1].
Dracorhodin (0-200 μM; 48 h) inhibits the growth of human gastric adenocarcinoma SGC-7901 cells in a dose-dependent manner[2].
Dracorhodin (0.625-40 μg/mL; 24 h) promotes the proliferation of NIH/3T3 fibroblasts at concentrations of 0.625-10 μg/mL and inhibits proliferation at concentrations >20 μg/mL[3].
Dracorhodin (10-80 μM；12-48 h) inhibits the growth of human prostate cancer PC-3 cells in a dose-and time-dependent manner, with an IC50 of 40.18 μM at 24 h[4].
Dracorhodin (40-150 μM; 12-48 h) inhibits the growth of MCF-7 cells in a dose-and time-dependent manner[5].
Dracorhodin (10 μg/mL; 3-9 h) upregulates Pdx1 expression in INS-1 cells[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
Dracorhodin (200 μg/mL; topical application) promotes skin wound healing, collagen deposition, and microvascular formation in diabetic rats by regulating the TLR4 pathway and related inflammatory factors[6].
Dracorhodin (5-20 mg/kg; i.p.; every other day; 30 d) lowers blood glucose, raises insulin levels, enhances Pdx1 expression, increases islet size and number, and shows protective effects on islets and β-cells in diabetic mice[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- RNA extraction experimental
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Annexin V plus membrane-impermeant dye apoptosis staining
- ROS/oxidative-stress fluorescent staining
- Cell migration
- Apoptosis Solutions
- Research Protocol for Inflammation-related Diseases
- Cell-Exclusion Zone Migration Assay
- Research Protocol for Metabolic Diseases
- Breast Cancer Modeling
化学情報
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CAS 番号 643-56-1
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性状 Solid
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分子量 266.29
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分子式 C17H14O3
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Color Brown to reddish brown
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SMILES
O=C(C(C)=C1OC)C=C2C1=CC=C(C3=CC=CC=C3)O2
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
Dracorhodin perochlorate sensitizes colorectal cancer to ferroptosis by activating HMOX1 and inhibiting the SLC7A11/GPX4 axis. [Abstract]2025 Jun 17:158:114827. PMID: 40359890 -
溶剤 & 溶解度
体外:
DMSO : 10.6516 mg/mL (40.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
DMSO : 5 mg/mL (18.78 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (291 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Rasul A, et al. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis. Apoptosis. 2012 Oct;17(10):1104-19. [Content Brief]
[2]. Xia M, et al. Dracorhodin perchlorate induces apoptosis via activation of caspases and generation of reactive oxygen species. J Pharmacol Sci. 2004 Jun;95(2):273-83. [Content Brief]
[3]. Jiang X, et al. Dracorhodin perchlorate regulates fibroblast proliferation to promote rat's wound healing. J Pharmacol Sci. 2018 Feb;136(2):66-72. [Content Brief]
[4]. He Y, et al. Dracorhodin perchlorate suppresses proliferation and induces apoptosis in human prostate cancer cell line PC-3. J Huazhong Univ Sci Technolog Med Sci. 2011 Apr;31(2):215. [Content Brief]
[5]. Yu JH, et al. Dracorhodin perchlorate induced human breast cancer MCF-7 apoptosis through mitochondrial pathways. Int J Med Sci. 2013 Jul 7;10(9):1149-56. [Content Brief]
[6]. Xiong Z, et al. Dracorhodin Perchlorate Regulates the Expression of Inflammatory Cytokines through the TLR4 Pathway and Improves Skin Wound Healing in Diabetic Rats. Evid Based Complement Alternat Med. 2022 Apr 14;2022:9050686. [Content Brief]
[7]. Liu L, et al. Dracorhodin perchlorate protects pancreatic β-cells against glucotoxicity- or lipotoxicity-induced dysfunction and apoptosis in vitro and in vivo. FEBS J. 2019 Sep;286(18):3718-3736. [Content Brief]
[8]. Chen X, et al. Dracorhodin perchlorate induces the apoptosis of glioma cells. Oncol Rep. 2016 Apr;35(4):2364-72. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / DMSO | 1 mM | 3.7553 mL | 18.7765 mL | 37.5530 mL | 93.8826 mL |
| 5 mM | 0.7511 mL | 3.7553 mL | 7.5106 mL | 18.7765 mL | |
| 10 mM | 0.3755 mL | 1.8777 mL | 3.7553 mL | 9.3883 mL | |
| 15 mM | 0.2504 mL | 1.2518 mL | 2.5035 mL | 6.2588 mL | |
| DMSO | 20 mM | 0.1878 mL | 0.9388 mL | 1.8777 mL | 4.6941 mL |
| 25 mM | 0.1502 mL | 0.7511 mL | 1.5021 mL | 3.7553 mL | |
| 30 mM | 0.1252 mL | 0.6259 mL | 1.2518 mL | 3.1294 mL |
Dracorhodin 関連分類
HY-N4081 関連分類
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Keywords
- Dracorhodin
- 643-56-1
- Apoptosis
- Akt
- PI3K
- NF-κB
- MDM-2/p53
- Caspase
- Reactive Oxygen Species (ROS)
- Toll-like Receptor (TLR)
- PARP
- PKB
- Protein kinase B
- Phosphoinositide 3-kinase
- Nuclear factor-κB
- Nuclear factor-kappaB
- poly ADP ribose polymerase
- PC-3
- MCF-7
- INS-1
- SGC-7901
- HeLa
- diabetic
- wound healing
- Pro-apoptotic
- Inhibitor
- inhibitor
- inhibit