Maoa - monoamine oxidase A Gene

Also Known as Mao

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29253

About Maoa

Primary_assembly X: 6,030,795-6,099,593 reverse strand.mRatBN7.2:CM026994.1

This gene has 2 transcripts (splice variants), 147 orthologues, 10 paralogues and is associated with 26 phenotypes. Biased expression in Heart (RPKM 1152.5), Liver (RPKM 471.7) and 8 other tissues.

Summary

Enables flavin adenine dinucleotide binding activity; primary amine oxidase activity; and serotonin binding activity. Involved in phenylethylamine metabolic process and serotonin metabolic process. Located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; Brunner Syndrome; alcohol use disorder; autism spectrum disorder; and panic disorder. Orthologous to human MAOA (Monoamine Oxidase A). [provided by Alliance of Genome Resources, Apr 2022]

Maoa Products (1)

mRNA Protein Name
NM_033653.1 NP_387502.1 amine oxidase [flavin-containing] A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
11754741 RGD
enables flavin adenine dinucleotide binding IMP
IMP: Inferred from mutant phenotype
11754741 RGD
enables monoamine oxidase activity IDA
IDA: Inferred from direct assay
20493079 RGD
enables primary methylamine oxidase activity IDA
IDA: Inferred from direct assay
9162023 RGD
enables primary methylamine oxidase activity IMP
IMP: Inferred from mutant phenotype
11754741 RGD
enables serotonin binding IDA
IDA: Inferred from direct assay
11263670 RGD
enables serotonin binding IMP
IMP: Inferred from mutant phenotype
11754741 RGD
Biological Process GO Annotation Evidence References Source
involved in phenylethylamine metabolic process IDA
IDA: Inferred from direct assay
11754741 RGD
involved in phenylethylamine metabolic process IMP
IMP: Inferred from mutant phenotype
11754741 RGD
involved in serotonin metabolic process IDA
IDA: Inferred from direct assay
11263670 RGD
involved in serotonin metabolic process IMP
IMP: Inferred from mutant phenotype
11754741 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
11263670 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Maoa Protein Structure

YobN

YobN: COG1231 (14 - 462)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 526 a.a.
Protein Preferred Names Protein Names

amine oxidase [flavin-containing] A

  • MAO-A

  • monoamine oxidase type A

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (27)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14536 Methylene Blue Inhibitor 95.05% Unkown
HY-14199 Selegiline hydrochloride Inhibitor 99.96% Unkown
HY-14280 Entacapone Inhibitor 99.97% Yes
HY-14197A Clorgyline hydrochloride Inhibitor 99.92% Unkown
HY-N0159 Paeonol 99.98% Unkown
HY-B1018A Phenelzine sulfate Inhibitor 99.96% Unkown
HY-A0091A Pargyline Inhibitor 99.92% Unkown
HY-70057 Safinamide Inhibitor 99.86% Yes
HY-A0091 Pargyline hydrochloride Inhibitor 99.91% Unkown
HY-B1359 Methylene blue trihydrate Inhibitor 98.0% Yes
HY-14197 Clorgyline Inhibitor 99.76% Unkown
HY-B0534 Moclobemide Inhibitor 99.12% Yes
HY-70057A Safinamide mesylate Inhibitor 99.07% Yes
HY-14855B Tedizolid phosphate Inhibitor 99.61% Yes
HY-D0958 Methylene blue hydrate Inhibitor / Unkown
HY-B0678 Metaxalone 99.77% Unkown
HY-N0159R Paeonol (Standard) 99.98% Unkown
HY-14196 Toloxatone Inhibitor 98.11% Unkown
HY-B1558A Bifemelane hydrochloride Inhibitor 99.86% Unkown
HY-100679 Pirlindole Inhibitor 98.90% Unkown
HY-14895 Fabomotizole 99.96% Unkown
HY-14198 Selegiline Inhibitor / Unkown
HY-14280R Entacapone (Standard) Inhibitor 99.24% Unkown
HY-100679A Pirlindole mesylate Inhibitor / Unkown
HY-B0678R Metaxalone (Standard) / Unkown
HY-W018475 Rizatriptan Agonist / Unkown
HY-14280A Entacapone sodium salt Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-N0529 Rosmarinic acid 99.73% Phase 4
HY-120017 Befloxatone Inhibitor / Phase 3
HY-154977 ETAP Inhibitor / Phase 3
HY-13339 Brofaromine Inhibitor 99.37% Phase 2
HY-14260 RS 8359 Inhibitor 97.35% Phase 2
HY-129388 Pulrodemstat Methylbenzenesulfonate Inhibitor / Phase 2
HY-100178 CX-157 Inhibitor / Phase 2
HY-108048 Desoxypeganine Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (135)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W008566 Norharmane Inhibitor 99.93% Unkown
HY-129388B Pulrodemstat benzenesulfonate Inhibitor 99.64% Unkown
HY-B1311 Proadifen hydrochloride 99.95% Unkown
HY-Y1322 Triphenyl phosphate 99.67% Unkown
HY-N2554 Osthenol 99.15% Unkown
HY-N0126 Xanthone Inhibitor 99.97% Unkown
HY-W015490 1,4-Naphthoquinone Inhibitor 99.97% Unkown
HY-14536A Methylene blue (purity≥70%) Inhibitor 95.0% Unkown
HY-110130 RN-1 dihydrochloride Inhibitor 99.21% Unkown
HY-E70074 Monoamine oxidase, plasma / Unkown
HY-N4177 Rubrofusarin gentiobioside Inhibitor 99.07% Unkown
HY-164099 LSD1/HDAC6-IN-2 Inhibitor 99.66% Unkown
HY-19333 OG-L002 Inhibitor 99.55% Unkown
HY-124591 TC-2153 Inhibitor 98.19% Unkown
HY-N12485 MAO-A inhibitor 1 Inhibitor 98.55% Unkown
HY-129388A Pulrodemstat Inhibitor 98.86% Unkown
HY-16677A Mofegiline hydrochloride Inhibitor 99.57% Unkown
HY-131036 MAO-IN-M30 dihydrochloride Inhibitor 98.48% Unkown
HY-14201 Lazabemide Inhibitor 99.95% Unkown
HY-D0004 Azure B Inhibitor 99.87% Unkown
HY-N4246 Bacopaside I 99.20% Unkown
HY-100588 VU0364770 Agonist 99.94% Unkown
HY-137570 Ethyl homovanillate Inhibitor 98.41% Unkown
HY-149213 LSD1/TLK1-IN-1 99.20% Unkown
HY-W004882 6-Hydroxy-1-tetralone 99.56% Unkown
HY-W655727 (-)-2-Phenylpropylamine Inhibitor 98.44% Unkown
HY-125515 Tetrahydroharmine Inhibitor 99.61% Unkown
HY-100027A Ro 41-1049 hydrochloride Inhibitor 99.57% Unkown
HY-121072 ASS234 Inhibitor 99.6% Unkown
HY-145259 HDAC6-IN-3 Inhibitor 98.0% Unkown
HY-149408 MAOA-IN-1 Inhibitor 98.24% Unkown
HY-151466 HIF-1α-IN-5 Inhibitor 99.95% Unkown
HY-N0126R Xanthone (Standard) Inhibitor 99.99% Unkown
HY-W015490S 1,4-Naphthoquinone-d6 Inhibitor 99.20% Unkown
HY-W049881 9-Methyl-β-carboline 99.86% Unkown
HY-100588A VU0364770 hydrochloride Agonist 99.63% Unkown
HY-101578 2614W94 Inhibitor 99.76% Unkown
HY-114620 MAO-B-IN-55 Inhibitor 98.10% Unkown
HY-14280S Entacapone-d10 Inhibitor 98.6% Unkown
HY-151596 MAO-A/5-HT2AR-IN-1 Inhibitor 99.71% Unkown
HY-156255 MAO-B-IN-25 Inhibitor 99.11% Unkown
HY-70057S1 Safinamide-d4-1 Inhibitor 98.90% Unkown
HY-B1018AS Phenelzine-d5 sulfate Inhibitor 99.97% Unkown
HY-W010130 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone Inhibitor 99.96% Unkown
HY-W275048 MAO-A inhibitor 3 Inhibitor 99.85% Unkown
HY-Y1322S Triphenyl phosphate-d15 99.74% Unkown
HY-100027 Ro 41-1049 Inhibitor / Unkown
HY-100679B (R)-Pirlindole mesylate Inhibitor / Unkown
HY-106041A Sercloremine hydrochloride Inhibitor / Unkown
HY-106972 SL-251131 Inhibitor / Unkown
HY-108048A Desoxypeganine hydrochloride Inhibitor / Unkown
HY-114915 PSB-1434 Inhibitor 98.05% Unkown
HY-116097 PSB-1491 Inhibitor / Unkown
HY-119885A (±)-Amiflamine Inhibitor 99.23% Unkown
HY-129388C Pulrodemstat hydrochloride Inhibitor / Unkown
HY-129449 AnnH31 Inhibitor 99.91% Unkown
HY-131660 MAO-B-IN-54 Inhibitor / Unkown
HY-134664 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Inhibitor / Unkown
HY-135265 Moclobemide N-Oxide Inhibitor 99.35% Unkown
HY-136878 LSD1-IN-10 Inhibitor / Unkown
HY-14198B (±)-Selegiline hydrochloride Inhibitor / Unkown
HY-14202 Lazabemide hydrochloride Inhibitor 95.0% Unkown
HY-143438 2-PAT Inhibitor / Unkown
HY-144673 LSD1-IN-12 Inhibitor / Unkown
HY-144756 LSD1-IN-15 Inhibitor / Unkown
HY-144757 LSD1-IN-16 Inhibitor / Unkown
HY-144758 LSD1-IN-17 Inhibitor / Unkown
HY-149528 MAO-B-IN-24 Inhibitor / Unkown
HY-149978 LSD1-IN-26 / Unkown
HY-151094 FTEAA Inhibitor / Unkown
HY-151800 MAO-A/B-IN-2 Inhibitor / Unkown
HY-152109 AChE/MAO-IN-1 Inhibitor / Unkown
HY-152110 AChE/MAO-IN-2 Inhibitor / Unkown
HY-15386 Cimoxatone Inhibitor 98.03% Unkown
HY-157934 MAO-IN-4 Inhibitor / Unkown
HY-157981 AChE-IN-60 Inhibitor / Unkown
HY-157982 BChE-IN-28 Inhibitor / Unkown
HY-158092 ChEs/MAOs-IN-2 Inhibitor / Unkown
HY-158732 MAO-B-IN-33 Inhibitor / Unkown
HY-159106 MeSeI / Unkown
HY-161240 MAO-B-IN-30 Inhibitor 98.53% Unkown
HY-162606 MAO-A/B-IN-3 Inhibitor / Unkown
HY-162760 COMT-IN-1 Inhibitor / Unkown
HY-163322 MAO-A inhibitor 2 Inhibitor / Unkown
HY-163618 DHMQ / Unkown
HY-170487 MAO-B-IN-38 Inhibitor / Unkown
HY-174833 MAO-A-IN-2 Inhibitor / Unkown
HY-174834 MAO-B-IN-44 Inhibitor / Unkown
HY-176254 LSD1-IN-43 Inhibitor / Unkown
HY-176271 MAO-B-IN-45 / Unkown
HY-178149 MAO-A/B-IN-5 Inhibitor / Unkown
HY-178352 MAO-B-IN-49 / Unkown
HY-179126 BChE/MAO-A-IN-1 Inhibitor / Unkown
HY-180552 AChE-IN-104 Inhibitor / Unkown
HY-180783 AChE/BChE/MAO-A-IN-1 Inhibitor / Unkown
HY-180843 Aβ/tau aggregation-IN-4 Inhibitor / Unkown
HY-181110 MAO-A-IN-4 Inhibitor / Unkown
HY-182727 MDL 72392 Inhibitor / Unkown
HY-184159 AChE/BChE/MAO-A-IN-2 Inhibitor / Unkown
HY-184381 MAO-B-IN-61 Inhibitor / Unkown
HY-186195 Methyl-cudratricusxanthone B / Unkown
HY-186306 MAO-A-IN-5 Inhibitor / Unkown
HY-B0534S Moclobemide-d8 Inhibitor / Unkown
HY-B0534S1 Moclobemide-d4 Inhibitor 99.0% Unkown
HY-B0678S Metaxalone-d3 98.0% Unkown
HY-B0678S1 Metaxalone-d6 / Unkown
HY-D3221 MAO Probe 1 / Unkown
HY-N0377B (R)-Liquiritigenin Inhibitor / Unkown
HY-N1638 1-Methyl-2-undecyl-4(1H)-quinolone Inhibitor / Unkown
HY-N18471 5,7-Dihydroxytryptamine Ligand / Unkown
HY-N18471A 5,7-Dihydroxytryptamine hydrobromide Ligand / Unkown
HY-N18471B 5,7-Dihydroxytryptamine creatinine sulfate Ligand / Unkown
HY-RS08019 MAOA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08020 Maoa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08021 Maoa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W008566S Norharmane-13C / Unkown
HY-W1058437 (trans)-m-CI-PCA hydrochloride Inhibitor / Unkown
HY-100679S Pirlindole-d4 Inhibitor / Unkown
HY-105041 Tedizolid phosphate sodium Inhibitor / Unkown
HY-105127 Brofaromine hydrochloride Inhibitor / Unkown
HY-124331 H77-77 Inhibitor / Unkown
HY-124885 MD 220661 Inhibitor / Unkown
HY-14198S Selegiline-d5 Inhibitor / Unkown
HY-14199S Selegiline-d5 hydrochloride Inhibitor / Unkown
HY-160936 5-Hydroxyindoleacetaldehyde / Unkown
HY-167152 Pirlindole lactate Inhibitor / Unkown
HY-19333A OG-L002 hydrochloride Inhibitor / Unkown
HY-70057S4 Safinamide-d5 Inhibitor / Unkown
HY-N12134 Methyl piperate Inhibitor / Unkown
HY-N13041 Acacetin 7-O-(6-O-malonylglucoside) Inhibitor / Unkown
HY-W029600 6,7-Dimethylisatin Inhibitor / Unkown
HY-W067583 Norharmine Inhibitor / Unkown
HY-W279140 Pirlindole hydrochloride Inhibitor / Unkown
HY-W700241 Norharman-d7 Inhibitor / Unkown
HY-W792513 WAY-620147 Inhibitor 98.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Maoa NCBI NCBI:4128