Tlr7 - toll-like receptor 7 Gene

Also Known as RGD1563357

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 317468

About Tlr7

Primary_assembly X: 27,027,425-27,054,754 forward strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 197 orthologues, 26 paralogues and is associated with 16 phenotypes. Biased expression in Spleen (RPKM 25.2), Thymus (RPKM 42.9) and 7 other tissues.

Summary

Predicted to enable RNA binding activity and pattern recognition receptor activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of cytokine production; and response to virus. Predicted to act upstream of or within regulation of protein phosphorylation. Predicted to be located in cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in COVID-19 and X-Linked immunodeficiency 74. Orthologous to human TLR7 (toll like receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Tlr7 Products (1)

mRNA Protein Name
NM_001097582.1 NP_001091051.1 toll-like receptor 7

Tlr7 Protein Structure

LRR_RI

LRR_RI: sd00033 (65 - 86)

LRR_8

LRR_8: pfam13855 (92 - 156)

LRR_RI

LRR_RI: sd00033 (108 - 145)

LRR_RI

LRR_RI: sd00033 (146 - 190)

LRR_RI

LRR_RI: sd00033 (191 - 222)

PLN00113

PLN00113: cl33413 (207 - 751)

LRR_RI

LRR_RI: sd00033 (223 - 243)

LRR_RI

LRR_RI: sd00033 (244 - 267)

LRR_RI

LRR_RI: sd00033 (268 - 308)

LRR_RI

LRR_RI: sd00033 (309 - 332)

LRR_RI

LRR_RI: sd00033 (333 - 358)

LRR_RI

LRR_RI: sd00033 (369 - 388)

LRR_RI

LRR_RI: sd00033 (389 - 415)

LRR_RI

LRR_RI: sd00033 (416 - 439)

LRR_RI

LRR_RI: sd00033 (514 - 536)

LRR_RI

LRR_RI: sd00033 (537 - 561)

LRR_RI

LRR_RI: sd00033 (562 - 585)

LRR_RI

LRR_RI: sd00033 (586 - 615)

LRR_RI

LRR_RI: sd00033 (616 - 638)

LRR_RI

LRR_RI: sd00033 (639 - 669)

LRR_RI

LRR_RI: sd00033 (670 - 694)

LRR_RI

LRR_RI: sd00033 (695 - 718)

LRR_RI

LRR_RI: sd00033 (719 - 742)

LRR_8

LRR_8: cl38440 (742 - 785)

LRR_RI

LRR_RI: sd00033 (767 - 785)

TIR

TIR: smart00255 (908 - 1053)

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  • 1000
  • 1068 a.a.
Protein Preferred Names Protein Names

toll-like receptor 7

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0180 Imiquimod Agonist 99.96% Unkown
HY-B1370 Hydroxychloroquine sulfate Inhibitor 99.99% Yes
HY-B0180A Imiquimod hydrochloride Agonist 99.77% Yes
HY-B0180B Imiquimod maleate Agonist 99.92% Yes
HY-B1370A (S)-Hydroxychloroquine Inhibitor / Unkown
HY-B1370B (R)-Hydroxychloroquine Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-W008634 Bropirimine Agonist 99.94% Phase 3
HY-13740 Resiquimod Agonist 99.95% Phase 2
HY-134581 Enpatoran Inhibitor 99.80% Phase 2
HY-15601 Vesatolimod Agonist 99.90% Phase 2
HY-134581A Enpatoran hydrochloride Inhibitor 99.42% Phase 2
HY-13740G Resiquimod (GMP) Agonist / Phase 2
HY-108472 Loxoribine Agonist 99.94% Phase 2
HY-111269 AZD8848 Agonist 99.14% Phase 2
HY-100176 PF-4878691 Agonist 99.89% Phase 2
HY-118250 GSK2245035 Agonist 99.79% Phase 2
HY-139575 Guretolimod Agonist / Phase 2
HY-177617 Bazlitoran Agonist 95.30% Phase 2
HY-177617A Bazlitoran sodium Agonist 95.30% Phase 2
HY-13655A Isatoribine Agonist / Phase 2
HY-109104 Telratolimod Agonist 98.85% Phase 1
HY-111786 LHC-165 Agonist 98.0% Phase 1
HY-178166 ETI41 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (92)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0201 Atractylenolide I Antagonist 99.98% Unkown
HY-124603 AT791 Inhibitor 98.77% Unkown
HY-128799 CL097 Agonist 99.90% Unkown
HY-160229 ssRNA40 sodium Activator 98.34% Unkown
HY-12756 E6446 Antagonist 98.78% Unkown
HY-12756A E6446 dihydrochloride Antagonist 99.29% Unkown
HY-103697 Gardiquimod 99.91% Unkown
HY-103698 TLR7/8 agonist 1 Agonist 98.42% Unkown
HY-139323 TLR7/8-IN-1 Inhibitor 99.92% Unkown
HY-135905 CL264 Inhibitor 98.63% Unkown
HY-103698A TLR7/8 agonist 1 dihydrochloride Agonist 99.70% Unkown
HY-110120 DSR-6434 Agonist 99.32% Unkown
HY-128799A CL097 hydrochloride Agonist 99.96% Unkown
HY-111582 BBIQ Agonist 99.81% Unkown
HY-B1370R Hydroxychloroquine sulfate (Standard) Inhibitor 99.96% Unkown
HY-160227A ORN 06 sodium Activator 95.05% Unkown
HY-130797 TLR7/8 agonist 3 Agonist 99.96% Unkown
HY-153879 C12-TLRa Ligand 99.71% Unkown
HY-111358 TLR7 agonist 1 Agonist 98.19% Unkown
HY-159102 PVP-037.2 Agonist 99.18% Unkown
HY-156174 E104 Inhibitor 99.38% Unkown
HY-117602 TLR7 agonist 3 Agonist 99.90% Unkown
HY-13740S Resiquimod-d5 Agonist 98.33% Unkown
HY-115400 1V209 Agonist 99.67% Unkown
HY-150736 ODN 20844 Inhibitor 96.14% Unkown
HY-139017 TLR7/8 agonist 4 Agonist 99.18% Unkown
HY-138139B AXC-715 trihydrochloride Agonist 99.76% Unkown
HY-131945 CU-115 Antagonist 99.63% Unkown
HY-103697A Gardiquimod diTFA 99.0% Unkown
HY-138139A AXC-715 hydrochloride Agonist 99.89% Unkown
HY-110207 SM-324405 Agonist 98.52% Unkown
HY-145885 TLR7/8 agonist 6 Agonist 98.93% Unkown
HY-156693A MTvkPABC-P5 TFA Agonist 98.78% Unkown
HY-176774 L07-2 Agonist 99.83% Unkown
HY-157793 SMU-L11 Agonist 99.64% Unkown
HY-158694A TLR7 agonist 20 hydrochloride Agonist 99.86% Unkown
HY-145960A MC-Val-Cit-PAB-Amide-TLR7 agonist 4 formic Agonist 97.70% Unkown
HY-164485 INI-4001 Activator / Unkown
HY-145961 TLR7 agonist 4 Agonist 98.87% Unkown
HY-150158 TMX-201 ≥95.0% Unkown
HY-150744 ODN 24888 Inhibitor / Unkown
HY-10018 Toll-like receptor modulator Modulator 99.36% Unkown
HY-153543 TLR7/8 agonist 8 Agonist 98.69% Unkown
HY-179474 TSI-13-57 Inhibitor 98.73% Unkown
HY-178037 TLR9 antagonist 1 Antagonist / Unkown
HY-153071 TLR7 agonist 6 Agonist 98.08% Unkown
HY-145960 MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Agonist 99.39% Unkown
HY-101589 Sotirimod Agonist 99.90% Unkown
HY-139017A TLR7/8 agonist 4 TFA Agonist / Unkown
HY-147215 UC-1V150 Agonist / Unkown
HY-141454A TLR8 agonist 2 hydrochloride Agonist / Unkown
HY-141454 TLR8 agonist 2 Agonist / Unkown
HY-162845 TLR7/8 agonist 11 Agonist / Unkown
HY-176553 KBD4466 Inhibitor / Unkown
HY-175782 SMU-R39 Antagonist / Unkown
HY-181796 TLR7 antagonist-1 Antagonist / Unkown
HY-160227 ORN 06 Activator / Unkown
HY-169017 MTT5 Agonist 98.49% Unkown
HY-153072 TLR7 agonist 7 Agonist / Unkown
HY-162115 TLR7 agonist 17 Agonist / Unkown
HY-169057 BI1543673 Inhibitor / Unkown
HY-178169 ETI60 Inhibitor 99.51% Unkown
HY-173070 TLR7 agonist 29 Agonist / Unkown
HY-152726 TLR7 agonist 9 Agonist / Unkown
HY-117686 AZ12441970 Agonist / Unkown
HY-179336 TLR7/8 agonist 14 Agonist / Unkown
HY-179047 SMU-L11-R Agonist / Unkown
HY-170899 TLR7 agonist 28 Agonist / Unkown
HY-162725 TLR7 agonist 24 Agonist / Unkown
HY-179209 TLR9-IN-2 Inhibitor / Unkown
HY-145886 TLR7/8 antagonist 1 Antagonist / Unkown
HY-158694 TLR7 agonist 20 Agonist / Unkown
HY-163670 TLR7 agonist 21 Inhibitor / Unkown
HY-175421 ArMan Activator / Unkown
HY-153544 TLR7/8 agonist 9 Inhibitor / Unkown
HY-168159 TLR7 agonist 27 Agonist / Unkown
HY-121496 3M-011 Agonist / Unkown
HY-179007 TLR7 agonist 31 Agonist / Unkown
HY-183079 ENDO12 Inhibitor / Unkown
HY-153070 TLR7 agonist 5 Agonist / Unkown
HY-156175 TLR7 agonist 14 Agonist / Unkown
HY-153073 TLR7 agonist 8 Agonist / Unkown
HY-159916 AYK004 Agonist / Unkown
HY-159914 AYK004-B1 Agonist / Unkown
HY-168157 TLR7 agonist 26 Agonist / Unkown
HY-163398 TLR7-IN-1 Inhibitor / Unkown
HY-177300 TLR7/8 agonist 13 Agonist / Unkown
HY-165632 Creatine ethyl ester Activator / Unkown
HY-183400 BIM-46174 Inhibitor / Unkown
HY-159919 UM-3006 Agonist / Unkown
HY-131920 Poly(U) Agonist / Unkown
HY-111582G BBIQ (GMP) Agonist / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992348 DS-7011a Inhibitor / Unkown
HY-P991956 ABB071 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlr7 NCBI NCBI:51284
Mus musculus Tlr7 NCBI NCBI:170743