Myrothecine A
Myrothecine A is a trichothecene mycotoxin found in M. roridum. Myrothecine A induces apoptosis, promotes the cytochrome c release, PARP-cleavage and phosphorylation of JNK, increases Bax and cleaved caspase-3, -5, and -8 levels. Myrothecine A has anticancer activities and promotes the maturation of DC cells in the microenvironment. Myrothecine A inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells with IC50s of 95, 70, 60, and 25 µM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 910292-40-9
- Formula: C29H38O10
- Molecular Weight:546.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Caspase 3 |
Caspase-5 |
Caspase-8 |
Bax |
Chemical Information
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CAS No. 910292-40-9
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Molecular Weight 546.61
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Formula C29H38O10
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SMILES
CC1([C@@](OC(/C=C\CC[C@@]23C(C)=O)=O)([H])C[C@@]4([H])O5)[C@](CC[C@](O)6C)(COC(/C=C(CCO3)\[C@H]2O)=O)[C@H]5[C@]6([H])CC14O
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Structure Classification
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Initial Source
Myrothecium roridum
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. 1. Fu Y, et al. Myrothecine A modulates the proliferation of HCC cells and the maturation of dendritic cells through downregulating miR-221. Int Immunopharmacol. 2019 Oct;75:105783. [Content Brief]
[2]. 2. Lin T, et al. Structure elucidation and biological activity of two new trichothecenes from an endophyte, Myrothecium roridum. J Agric Food Chem. 2014 Jun 25;62(25):5993-6000. [Content Brief]
[3]. 3. Song H, et al. Mytoxin B and Myrothecine A Induce Apoptosis in Human Hepatocarcinoma Cell Line SMMC-7721 via PI3K/Akt Signaling Pathway. Molecules. 2019 Jun 20;24(12):2291. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Myrothecine A Related Classifications
HY-N8508 Related Classifications
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