Referencia número: HY-100977S

Dimethoxycurcumin-d₆

Name: Dimethoxycurcumin-d6
Brand: MedChemExpress
SKU: HY-100977S
Availability: PreOrder

(Synonyms: DiMC-d₆; CHC 004-d₆; Di-O-methylcurcumin-d₆)

Dimethoxycurcumin-d₆ (DiMC-d₆; CHC 004-d₆; Di-O-methylcurcumin-d₆) is the deuterated-labeled Dimethoxycurcumin (HY-100977). Dimethoxycurcumin (DiMC) is a curcuminoid compound found in Curcuma longa. Dimethoxycurcumin is also an orally active thioredoxin reductase inhibitor (IC₅₀ = 5.4 μM) and androgen receptor antagonist. Dimethoxycurcumin inhibits thioredoxin reductase, leading to oxidized thioredoxin accumulation, ROS production, DNA damage, glutathione depletion, mitochondrial membrane potential decrease, ATP depletion, S phase arrest, and apoptosis. Dimethoxycurcumin inhibits NF-κB, NADPH oxidase subunits, ATP synthase subunits, CDK4, cyclin-D1, FASN, ACC, and the IRS2-PI3K-Akt pathway, while activating AMPK, ERK, and JNK. Dimethoxycurcumin can be used for research on cancer, arsenic-induced hepatotoxicity, and tuberculosis.

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No. CAS: 3006902-95-7
Fòrmula: C₂₃H₁₈D₆O₆
Peso molecular:402.47

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

Dimethoxycurcumin-d₆ Chemical Structure

No. CAS: 3006902-95-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Aplicación
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]^[10]^[11]^[12]

thioredoxin reductase

5.4 μM (IC₅₀)

Androgen receptor

NF-κB

CDK4

cyclin-D1

FASN

ACC

IRS2

PI3K

Akt

AMPK

ERK

JNK

Ver todos los productos específicos de isoformas NF-κB :

Ver todos los productos específicos de isoformas CDK :

Ver todos los productos específicos de isoformas PI3K :

Ver todos los productos específicos de isoformas Akt :

Ver todos los productos específicos de isoformas AMPK :

Ver todos los productos específicos de isoformas ERK :

Ver todos los productos específicos de isoformas JNK :

Aplicación

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

No. CAS 3006902-95-7
Unlabeled CAS 160096-59-3
Peso molecular 402.47
Fòrmula C₂₃H₁₈D₆O₆
SMILES

COC1=C(C=CC(/C=C/C(CC(/C=C/C2=CC(OC)=C(C=C2)OC([2H])([2H])[2H])=O)=O)=C1)OC([2H])([2H])[2H]
Synonyms

DiMC-d₆; CHC 004-d₆; Di-O-methylcurcumin-d₆
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Miltonprabu S, et al. Dimethoxycurcumin potentially protects arsenic induced oxidative hepatic injury, inflammation and apoptosis via Nrf2-Keap1 signaling in rats. Biomedicine & Preventive Nutrition. 2014 Oct 1;4(4):561-77.

[2]. Kunwar A, et al. Dimethoxycurcumin-induced cell death in human breast carcinoma MCF7 cells: evidence for pro-oxidant activity, mitochondrial dysfunction, and apoptosis. Archives of toxicology. 2012 Apr;86(4):603-14.

[3]. Hatamipour M, et al. Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties. Journal of cellular physiology. 2018 Dec;233(12):9247-9260.

[4]. Patwardhan RS, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochemical pharmacology. 2011 Sep 15;82(6):642-57. [Content Brief]

[5]. Zoi V, et al. Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers. Biomedicines. 2022 Jan 28;10(2):312.

[6]. Jayakumar S, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductase. Biochemical and biophysical research communications. 2016 Sep 09;478(1):446-454.

[7]. Liu H, et al. Preparation, characterization, in vivo pharmacokinetics, and biodistribution of polymeric micellar dimethoxycurcumin for tumor targeting. International journal of nanomedicine. 2015;10:6395-410.

[8]. Yoon MJ, et al. Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin. Cell death & disease. 2014 Mar 13;5(3):e1112. [Content Brief]

[9]. Nelen J, et al. Targeting Drug Resistance in Cancer: Dimethoxycurcumin as a Functional Antioxidant Targeting ABCC3. Antioxidants (Basel, Switzerland). 2025 May 16;14(5):599.

[10]. Tamvakopoulos C, et al. Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 Feb 15;13(4):1269-77.

[11]. Zanetti TA, et al. Dimethoxycurcumin reduces proliferation and induces apoptosis in renal tumor cells more efficiently than demethoxycurcumin and curcumin. Chemico-biological interactions. 2021 Apr 01;338:109410.

[12]. Changtam C, et al. Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity. European journal of medicinal chemistry. 2010 Oct;45(10):4446-57.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Dimethoxycurcumin-d₆

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Dimethoxycurcumin-d₆

Ver todos los productos específicos de isoformas NF-κB

Ver todos los productos específicos de isoformas CDK

Ver todos los productos específicos de isoformas PI3K

Ver todos los productos específicos de isoformas Akt

Ver todos los productos específicos de isoformas AMPK

Ver todos los productos específicos de isoformas ERK

Ver todos los productos específicos de isoformas JNK