4′-Hydroxywogonin
Based on 1 Customer Validation
4′-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis.
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- Reinheit: 98.22%
- CAS. Nr.: 57096-02-3
- Formel: C16H12O6
- Molecular Weight:300.26
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
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| RAW264.7 | IC50 |
12.5 μM
Compound: 11
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Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by Griess reaction based method
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by Griess reaction based method
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[PMID: 25637363] |
4′-Hydroxywogonin (8-Methoxyapigenin; 0.5-15 μM; 0-24 h) has low cytotoxicity and inhibits NO and PGE2 production in LPS-stimulated RAW 264.7 macrophages by suppression of iNOS and COX-2 expression[1].
4′-Hydroxywogonin (0.5-15 μM; 1 and 12 h) suppresses LPS-induced expression of pro-inflammatory cytokines in RAW 264.7 macrophages and suppresses LPS-induced activation of NF-κB[1].
4′-Hydroxywogonin (0.5-15 μM; 1 h) suppresses LPS-induced degradation of IκB-α and activation of IKK and TAK and suppresses the phosphorylation of MAPK and AKTin in RAW 264.7 macrophages[1].
4′-Hydroxywogonin (0.5-15 μM; 24 h) inhibits ROS production in LPS-stimulated RAW 264.7 macrophages[1].
4′-Hydroxywogonin (0-10 μg/mL; 24 h) reduces the viability of SW620 cells in a concentration- and time-dependent manner and decreases the mRNA and protein expression of vascular endothelial growth factor-A (VEGF-A), the predominant pro-angiogenic cytokine in tumor angiogenesis[2].
4′-Hydroxywogonin (24 h; SUP-B15 and Jurkat cells) induces apoptosis and decreases the expression of C-MYC, BCL-2 and cleaved caspase 3[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 macrophages
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Concentration:0.5, 5 and 15 μM
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Incubation Time:24 hours
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Result:Had low cytotoxicity in RAW 264.7 macrophages.
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Cell Line:RAW 264.7 macrophages
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Concentration:0.5, 5 and 15 μM
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Incubation Time:1 hours
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Result:Attenuated the increase of iNOS and COX-2 mRNA expression induced by LPS in RAW 264.7 cells.
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Cell Line:RAW 264.7 macrophages
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Concentration:0.5, 5 and 15 μM
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Incubation Time:1 and 12 hours
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Result:Reduced TNF-α, IL-6 and IL-1β mRNA expression in a dose-dependent manner.
Inhibited LPS-induced p65 phosphorylation and nuclear translocation.
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Cell Line:RAW 264.7 macrophages
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Concentration:0.5, 5 and 15 μM
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Incubation Time:1 hours
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Result:Attenuated LPS induced IκB-α degradation.
Attenuated the phosphorylation of ERK1/2 and p38 in a dose-dependent manner.
Reduced the intensity of the TAK1/TAB1 band.
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Cell Line:SW620 cells
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Concentration:0.1, 1, and 10 μg/mL
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Incubation Time:24 hours
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Result:Downregulated VEGF-Aexpression in colorectal cancer cells and suppressed angiogenesis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6 mice (6-8 weeks old; 20 g) with acute lung injury model[1]
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Dosage:10 and 20 mg/kg
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Administration:Intraperitoneal injection, 12 and 1 h before LPS treatment
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Result:Had potential protective effects against inflammation in LPS induced ALI mice.
Attenuated the degree of leukocyte infiltration.
Chemical Information
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CAS. Nr. 57096-02-3
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Appearance Solid
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Molecular Weight 300.26
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Formel C16H12O6
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Color Brown to breen
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SMILES
O=C1C=C(C2=CC=C(O)C=C2)OC3=C(OC)C(O)=CC(O)=C13
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Synonyms
8-Methoxyapigenin
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
4′-Hydroxywogonin Related Classifications
HY-N1904 Related Classifications
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