Cdk9 - cyclin-dependent kinase 9 (CDC2-related kinase) Gene

Also Known as PITALRE

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107951

About Cdk9

Chromosome 2: 32,595,796-32,603,088 reverse strand.GRCm39:CM000995.3

This gene has 9 transcripts (splice variants), 208 orthologues, 25 paralogues and is associated with 15 phenotypes. Ubiquitous expression in ovary adult (RPKM 28.4), thymus adult (RPKM 26.4) and 28 other tissues.

Summary

Enables several functions, including RNA polymerase II CTD heptapeptide repeat kinase activity; chromatin binding activity; and nucleic acid binding activity. Involved in positive regulation of histone H2B ubiquitination and positive regulation of histone phosphorylation. Located in nucleus. Part of cyclin/CDK positive transcription elongation factor complex. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human CDK9 (cyclin dependent kinase 9). [provided by Alliance of Genome Resources, Apr 2022]

Cdk9 Products (1)

mRNA Protein Name
NM_130860.3 NP_570930.1 cyclin-dependent kinase 9

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II CTD heptapeptide repeat kinase activity IMP
IMP: Inferred from mutant phenotype
22509028 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21245044 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16245309 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12037670 MGI
enables protein kinase binding IDA
IDA: Inferred from direct assay
22547058 MGI
enables snRNA binding IDA
IDA: Inferred from direct assay
16109376 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
20570862 MGI
Biological Process GO Annotation Evidence References Source
involved in regulation of mRNA 3'-end processing IMP
IMP: Inferred from mutant phenotype
19575011 MGI
Cellular Component GO Annotation Evidence References Source
part of cyclin/CDK positive transcription elongation factor complex IDA
IDA: Inferred from direct assay
23752591 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16109376 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk9 Protein Structure

STKc_CDK9

STKc_CDK9: cd07865 (5 - 314)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 9

  • cell division protein kinase 9

Cdk9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cdk9 Q99J95 Max Mus musculus P28574
Anti Bait CoIP
20434984
Intra
Cdk9 Q99J95 Srsf2 Mus musculus Q62093
Anti Bait CoIP
23663783
Intra
Cdk9 Q99J95 Brdt Mus musculus Q91Y44
Pull Down
20593818
Intra
Cdk9 Q99J95 Brdt Mus musculus Q91Y44
Anti Bait CoIP
22922464
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16297A Abemaciclib Inhibitor 99.97% Yes
HY-10492 Dinaciclib Inhibitor 99.80% Yes
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes

Clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Phase
HY-112272A Lerociclib dihydrochloride Inhibitor 98.51% Phase 3
HY-112088 AZD4573 Inhibitor 99.98% Phase 2
HY-X0009 Tambiciclib Inhibitor 99.68% Phase 2
HY-50940 AT7519 Inhibitor 99.69% Phase 2
HY-101212 Fadraciclib Inhibitor 99.77% Phase 2
HY-137478 KB-0742 Inhibitor 99.63% Phase 2
HY-13914 Roniciclib Inhibitor 98.00% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.90% Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10008 SNS-032 Inhibitor 99.91% Phase 1
HY-138293 SY-5609 Inhibitor 99.93% Phase 1
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-123954 BTX-A51 Inhibitor 98.99% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-12871B Atuveciclib Inhibitor 99.75% Phase 1
HY-15504 RGB-286638 Inhibitor 99.67% Phase 1
HY-111388B Romaciclib hydrochloride Inhibitor 99.98% Phase 1
HY-103019B (-)-Enitociclib Inhibitor 99.85% Phase 1
HY-153260 TP-1287 Inhibitor 95.93% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.26% Phase 1

Pre-clinical Phase

Bioactive Molecules (177)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0400 Wogonin Inhibitor 99.83% Unkown
HY-103618 THZ531 Inhibitor 99.86% Unkown
HY-12214A NVP-2 Inhibitor 99.05% Unkown
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Unkown
HY-103248 Toyocamycin Inhibitor 99.27% Unkown
HY-101257 YKL-5-124 Inhibitor 99.53% Unkown
HY-103019 Enitociclib Inhibitor 99.89% Unkown
HY-123937 THAL-SNS-032 Inhibitor 97.06% Unkown
HY-111388A Romaciclib monohydrochloride Inhibitor 99.29% Unkown
HY-18340 (R)​-​CR8 Inhibitor 99.52% Unkown
HY-130709 PROTAC CDK2/9 Degrader-1 Degrader 99.85% Unkown
HY-130665 TL12-186 Inhibitor 99.23% Unkown
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Unkown
HY-15878 LDC000067 Inhibitor 99.00% Unkown
HY-143584 AZ5576 Inhibitor 99.86% Unkown
HY-144117 GFB-12811 Inhibitor 98.04% Unkown
HY-11009 CGP60474 Inhibitor 98.90% Unkown
HY-13461A PHA-767491 hydrochloride Inhibitor 99.49% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-X0150 JSH-150 Inhibitor 98.36% Unkown
HY-18340A (R)-CR8 trihydrochloride Inhibitor 99.37% Unkown
HY-12422 Voruciclib Inhibitor 99.76% Unkown
HY-13461 PHA-767491 Inhibitor 99.97% Unkown
HY-103712 Samuraciclib Inhibitor 99.55% Unkown
HY-173523 KI-CDK9d-32 Degrader 99.03% Unkown
HY-103019A (±)-Enitociclib Inhibitor 99.23% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-16559 Riviciclib hydrochloride 99.08% Unkown
HY-112626 CDK12-IN-2 Inhibitor 99.36% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.93% Unkown
HY-119940 MC180295 Inhibitor 98.07% Unkown
HY-112272 Lerociclib Inhibitor 96.42% Unkown
HY-103628 PROTAC CDK9 Degrader-1 Inhibitor 99.55% Unkown
HY-162919 YK-2168 Inhibitor 98.05% Unkown
HY-13231 CDK9-IN-1 Inhibitor 98.52% Unkown
HY-12293 LY2857785 Inhibitor 99.21% Unkown
HY-101257B YKL-5-124 TFA Inhibitor 99.74% Unkown
HY-124639 CDK9 inhibitor HH1 Inhibitor 99.69% Unkown
HY-162706 BSJ-5-63 Degrader 99.97% Unkown
HY-169244 CDK-TCIP1 Inhibitor 98.86% Unkown
HY-50943 AT7519 Hydrochloride Inhibitor 99.16% Unkown
HY-112403 (S)-Roscovitine Inhibitor 99.15% Unkown
HY-15504A RGB-286638 free base Inhibitor 98.09% Unkown
HY-162037 CDDD11-8 Inhibitor 99.62% Unkown
HY-139329 CDK12-IN-6 Inhibitor 99.15% Unkown
HY-151069 TMX-2039 Inhibitor 99.42% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.94% Unkown
HY-13033 CDK-IN-2 Inhibitor 99.27% Unkown
HY-18944 FIT-039 Inhibitor 99.56% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.71% Unkown
HY-14372 BS-194 Inhibitor 99.13% Unkown
HY-16462 CDK9-IN-2 Inhibitor 98.72% Unkown
HY-12871 Atuveciclib Racemate Inhibitor 98.48% Unkown
HY-102039 CDK9-IN-8 Inhibitor 99.16% Unkown
HY-178861 dCDK9-202 Degrader 99.25% Unkown
HY-100950 ABC1183 Inhibitor 99.62% Unkown
HY-111388 SEL120-34A Inhibitor 99.49% Unkown
HY-111427 CDK8/19-IN-1 Inhibitor 98.08% Unkown
HY-168518 PROTAC CDK9 degrader-9 Degrader 99.25% Unkown
HY-126251 CDK9-IN-7 Inhibitor 98.05% Unkown
HY-100429 CAN508 Inhibitor 99.71% Unkown
HY-112811 PROTAC CDK9 degrader-2 Inhibitor 99.22% Unkown
HY-115728 PROTAC CDK9 degrader-4 Degrader 99.65% Unkown
HY-130852 CDK9-IN-11 Inhibitor 97.02% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.88% Unkown
HY-123955 Casein Kinase inhibitor A86 Inhibitor 99.26% Unkown
HY-119715 AG-012986 Inhibitor 99.78% Unkown
HY-155787 SHR5428 Inhibitor 99.80% Unkown
HY-50940A AT7519 TFA Inhibitor 99.75% Unkown
HY-176142 YX0798 Inhibitor 98.90% Unkown
HY-103646 CK7 Inhibitor 99.72% Unkown
HY-X0009A Tambiciclib dimaleate Inhibitor 99.53% Unkown
HY-176165 CDK9/EZH2-IN-1 Inhibitor 99.08% Unkown
HY-115714 CDK9-IN-12 Inhibitor 99.65% Unkown
HY-156084 LL-K9-3 Degrader 99.2% Unkown
HY-139328 CDK12-IN-5 Inhibitor 98.03% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-115729 PROTAC CDK9 ligand-1 Ligand 99.75% Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-143585 CDK9-IN-14 Inhibitor 99.91% Unkown
HY-130850 CDK9-IN-10 Inhibitor 98.09% Unkown
HY-161708 PROTAC FLT3/CDKs degrader-1 Degrader 98.00% Unkown
HY-12843 Bohemine Inhibitor 98.93% Unkown
HY-164906 TMX-2138 Degrader 98.99% Unkown
HY-112450 Olomoucine II Inhibitor 98.0% Unkown
HY-110368 BS-181 dihydrochloride Inhibitor / Unkown
HY-151436 ZLMT-12 Inhibitor / Unkown
HY-130001 CDK9-IN-9 Inhibitor / Unkown
HY-131063 CDK6/9-IN-1 Inhibitor / Unkown
HY-130980 N-Desmethyl FN-1501 Ligand / Unkown
HY-130981 FN-1501-propionic acid / Unkown
HY-182986 LS-Q2 Inhibitor / Unkown
HY-178733 A-1592668 Inhibitor / Unkown
HY-155153 CDK9-IN-24 Inhibitor / Unkown
HY-161709 FLT3/CDKs ligand-1 Degrader / Unkown
HY-183710 CDK9-IN-50 Inhibitor / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-177780 Cyclin K degrader 2 Degrader / Unkown
HY-111356 IIIM-290 Inhibitor / Unkown
HY-153718 KI-ARv-03 Inhibitor / Unkown
HY-162619 CDK9-IN-33 Inhibitor / Unkown
HY-168896 CDK9 autophagic degrader 1 Degrader / Unkown
HY-170978 PROTAC CDK9 degrader-11 Degrader / Unkown
HY-187016 CDK9 ligand-7 Ligand / Unkown
HY-173347 BLINK11 Inhibitor / Unkown
HY-179023 CDK9-IN-45 Inhibitor / Unkown
HY-181645 CDK12-IN-9 Inhibitor / Unkown
HY-150889 CDK9 ligand 1 Inhibitor / Unkown
HY-170979 CDK9 ligand 3 Ligand / Unkown
HY-149495 CP-07 Degrader / Unkown
HY-185339 CDK9-IN-48 Inhibitor / Unkown
HY-183698 CDK9-IN-51 Inhibitor / Unkown
HY-149963 PROTAC CDK9 degrader-6 Inhibitor / Unkown
HY-176451 CDK9 degrader-1 Degrader / Unkown
HY-178452 PROTAC CDK4/6/9 degrader 1 Degrader / Unkown
HY-185340 CDK9-IN-49 Inhibitor / Unkown
HY-170815 CDK4/9-IN-1 Inhibitor / Unkown
HY-137478B KB-0742 hydrochloride Inhibitor / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown
HY-156083 CDK9-IN-28 Inhibitor / Unkown
HY-170942 CDK9/PARP-IN-1 Inhibitor / Unkown
HY-183699 CDK9-IN-52 Inhibitor / Unkown
HY-149870 PROTAC CDK9 degrader-8 Inhibitor / Unkown
HY-184694 CDK9 ligand 6 Ligand / Unkown
HY-180124 CDK8-IN-20 Inhibitor / Unkown
HY-178039 CDK9-IN-42 Inhibitor / Unkown
HY-123034 CDKI-83 Inhibitor / Unkown
HY-119831 Rohitukine Inhibitor / Unkown
HY-150562 CDK9-IN-19 Inhibitor / Unkown
HY-161768 VCC972839:01 Inhibitor / Unkown
HY-121081A BAY-1112054 hydrochloride Inhibitor / Unkown
HY-180912 HS-36 Inhibitor / Unkown
HY-181569 CDK9-IN-46 Inhibitor / Unkown
HY-180355 SY-5102 Inhibitor / Unkown
HY-180817 CDK2-IN-55 Inhibitor 98.91% Unkown
HY-173481 CDK9-IN-37 Inhibitor / Unkown
HY-175013 CDK6/9-IN-2 Inhibitor / Unkown
HY-179633 ZLMT-72 Inhibitor / Unkown
HY-156795 PROTAC CDK9/CycT1 Degrader-2 Inhibitor / Unkown
HY-172891 CDK9/HDAC1/HDAC3-IN-1 Inhibitor / Unkown
HY-147794 CDK9-IN-41 Inhibitor 98.84% Unkown
HY-178112 CDK2-IN-47 Inhibitor / Unkown
HY-161463 CDK2-IN-28 Inhibitor / Unkown
HY-181275 CDK9 ligand 4 Ligand / Unkown
HY-157980 CDK9-IN-32 Inhibitor / Unkown
HY-150573 CDK2-IN-12 Inhibitor / Unkown
HY-139327 CDK12-IN-4 Inhibitor / Unkown
HY-149962 PROTAC CDK9 degrader-5 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-145408 CDK7/9-IN-1 Inhibitor / Unkown
HY-161595 CDK5-IN-4 Inhibitor / Unkown
HY-182470 AG-012986 dihydrochloride Inhibitor / Unkown
HY-168845 CDK2/9-IN-1 Inhibitor / Unkown
HY-179375 LCI133 Inhibitor / Unkown
HY-181231 PROTAC CDK9 degrader-12 Degrader / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-182810 CDK9 ligand 5 Ligand / Unkown
HY-153426 CDK9-IN-23 Inhibitor / Unkown
HY-184693 PROTAC CDK9 degrader-13 Degrader / Unkown
HY-178516 PROTAC CDK4/6/9 degrader 2 Degrader / Unkown
HY-173348 BLINK15 Inhibitor / Unkown
HY-164619 CDK9-IN-34 Inhibitor / Unkown
HY-108375 CDK9 ligand-Linker Conjugate 1 Ligand / Unkown
HY-161379 CLZX-205 Inhibitor / Unkown
HY-176736 CDK9-IN-40 Inhibitor / Unkown
HY-136841 SLM6 Inhibitor / Unkown
HY-147771 ZLWT-37 Inhibitor / Unkown
HY-173065 CDK9-IN-36 Inhibitor / Unkown
HY-150948 CDK12 ligand-2 Ligand / Unkown
HY-151984 CDK9-IN-22 Inhibitor / Unkown
HY-178499 CDK9-IN-44 Inhibitor / Unkown
HY-119120 JTK-101 Inhibitor / Unkown
HY-123826 CCT68127 Inhibitor / Unkown
HY-101212A (2S,3R)-Fadraciclib Inhibitor / Unkown
HY-11001A PHA-793887 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk9 NCBI NCBI:1025