MAHS-4
MAHS-4 is an inhibitor of thymidylate synthase (TS) and dihydrofolate reductase (DHFR), with IC50 values of 1.918 μM and 83.53 μM, respectively. MAHS-4 inhibits thymidylate biosynthesis, reduces tetrahydrofolate pool maintenance, and interferes with extracellular matrix remodeling. MAHS-4 induces G2/M phase cell cycle arrest, activates endogenous caspase-dependent apoptosis, decreases MMP protein levels, inhibits cell migration, increases intracellular NO levels, and promotes autophagy activity. MAHS-4 is applicable for cancer-related research.
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- Formel: C22H16ClFN6O3
- Molecular Weight:466.85
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Alle Caspase Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
|
Caspase-7 |
Caspase-9 |
MMP-7 |
MMP-9 |
PARP-1 |
Bcl-xL |
Bax |
MAHS-3 induces cell cycle arrest and upregulates the expression of p21 and p27; it activates endogenous caspase-dependent apoptosis and regulates the levels of Bax, Cas-7, Cas-9, Bcl-2 and PARP1[1].
MAHS-4 exhibits dose-dependent antiproliferative activity in various cancer cell lines, shows cytostatic activity in some cancer cell lines, and has significantly higher cytotoxicity against breast cancer cells than normal cells and non-tumorigenic cells; moreover, it has better cancer cell selectivity than MAHS-3 (HY-187513)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 466.85
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Formel C22H16ClFN6O3
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SMILES
CC1=NN(C2=CC=C(F)C=C2)C(N=C(CCl)N3CC4=NO[N+]([O-])=C4C5=CC=CC=C5)=C1C3=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MAHS-4 Related Classifications
HY-187514 Related Classifications
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- MAHS-4
- MAHS4
- MAHS 4
- Dihydrofolate reductase (DHFR)
- Thymidylate Synthase
- Bcl-2 Family
- Caspase
- PARP
- MMP
- Autophagy
- Apoptosis
- thymidylate synthase
- renal cancer
- prostate cancer
- non-small cell lung cancer
- human dihydrofolate reductase
- breast cancer cells
- intrinsic caspase-dependent apoptosis
- G2/M-stage cell cycle arrest
- leukemia
- matrix metalloproteinase-7
- Inhibitor
- inhibitor
- inhibit