MAHS-3
MAHS-3 is a thymidylate synthase (TS) and dihydrofolate reductase (DHFR) inhibitor, with IC50 values of 5.279 μM and 52.60 μM against human targets, respectively. MAHS-3 exhibits broad-spectrum antiproliferative activity against cancer cells, induces cell cycle arrest, activates endogenous caspase-dependent apoptosis, reduces MMP levels, inhibits cell migration, increases intracellular NO levels, and promotes autophagy activity. MAHS-3 can be used in cancer-related research.
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- Fòrmula: C22H17ClN6O3
- Peso molecular:448.86
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
|
MMP-9 |
MMP-7 |
PARP-1 |
Caspase-7 |
Caspase-9 |
Bcl-2 |
Bax |
MAHS-3 induces cell cycle arrest and upregulates the expression of p21 and p27; it activates endogenous caspase-dependent apoptosis and regulates the levels of Bax, Cas-7, Cas-9, Bcl-2 and PARP1[1].
MAHS-3 is a dual-target inhibitor that targets thymidylate synthase and dihydrofolate reductase, with IC50 values of 5.279 μM and 52.60 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 448.86
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Fòrmula C22H17ClN6O3
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SMILES
CC1=NN(C2=CC=CC=C2)C(N=C(CCl)N3CC4=NO[N+]([O-])=C4C5=CC=CC=C5)=C1C3=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAHS-3 Related Classifications
HY-187513 Related Classifications
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- MAHS-3
- MAHS3
- MAHS 3
- Dihydrofolate reductase (DHFR)
- Thymidylate Synthase
- MMP
- Caspase
- PARP
- Bcl-2 Family
- Apoptosis
- Autophagy
- intrinsic caspase-dependent apoptosis
- human dihydrofolate reductase
- non-small cell lung cancer
- matrix metalloproteinase-7
- thymidylate synthase
- G2/M-stage cell cycle arrest
- breast cancer cells
- leukemia
- leukemia cells
- colon cancer
- Inhibitor
- inhibitor
- inhibit