2. Gene
  3. BRAF - B-Raf proto-oncogene, serine/threonine kinase Gene

BRAF - B-Raf proto-oncogene, serine/threonine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Bos taurus
Gene ID: 536051 | Gene type: protein coding

About BRAF

Primary_assembly 4: 104,027,627-104,194,547 reverse strand.ARS-UCD1.2:CM008171.2

This gene has 3 transcripts (splice variants), 220 orthologues and 23 paralogues.

BRAF Products(13)

mRNA Protein Name
XM_005205916.4 XP_005205973.1 serine/threonine-protein kinase B-raf isoform X10
XM_024991190.1 XP_024846958.1 serine/threonine-protein kinase B-raf isoform X5
XM_024991193.1 XP_024846961.1 serine/threonine-protein kinase B-raf isoform X9
XM_024991191.1 XP_024846959.1 serine/threonine-protein kinase B-raf isoform X7
XM_005205918.2 XP_005205975.1 serine/threonine-protein kinase B-raf isoform X11
XM_024991189.1 XP_024846957.1 serine/threonine-protein kinase B-raf isoform X4
XM_024991186.1 XP_024846954.1 serine/threonine-protein kinase B-raf isoform X1
XM_024991187.1 XP_024846955.1 serine/threonine-protein kinase B-raf isoform X2
XM_024991188.1 XP_024846956.1 serine/threonine-protein kinase B-raf isoform X3
XM_024991194.1 XP_024846962.1 serine/threonine-protein kinase B-raf isoform X12
XM_005205917.4 XP_005205974.1 serine/threonine-protein kinase B-raf isoform X10
XM_005205911.4 XP_005205968.1 serine/threonine-protein kinase B-raf isoform X6
XM_024991192.1 XP_024846960.1 serine/threonine-protein kinase B-raf isoform X8

BRAF Protein Structure

RBD_BRAF

RBD_BRAF: cd17134 (152 - 230)

C1_B-Raf

C1_B-Raf: cd20871 (228 - 287)

STKc_Raf

STKc_Raf: cd14062 (461 - 708)

  • 0
  • 200
  • 400
  • 600
  • 797 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase B-raf

Related Agents

Approval
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10201 Sorafenib 99.85% Yes
HY-14660 Dabrafenib Inhibitor 99.94% Yes
HY-12057 Vemurafenib 99.90% Yes
HY-15605 Encorafenib Inhibitor 99.93% Yes
HY-18652 Avutometinib Inhibitor 99.43% Unkown
HY-10201A Sorafenib tosylate 99.98% Yes
HY-10201S Sorafenib-d3 99.57% Unkown
HY-10201R Sorafenib (Standard) 99.71% Unkown
HY-10201AR Sorafenib tosylate (Standard) / Unkown
Clinical Phase
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Phase
HY-148439 Daraxonrasib Inhibitor 99.96% Phase 3
HY-112089 Naporafenib Inhibitor 99.92% Phase 3
HY-132844 Tunlametinib Inhibitor 99.53% Phase 3
HY-10320 Doramapimod Inhibitor 99.98% Phase 2
HY-109080 Belvarafenib Inhibitor 98.97% Phase 2
HY-18972 Plixorafenib Inhibitor 99.80% Phase 2
HY-114491 Rineterkib Inhibitor 98.79% Phase 2
HY-111940 LUT014 97.09% Phase 2
HY-114491A Rineterkib hydrochloride Inhibitor 99.81% Phase 2
HY-109080A Belvarafenib TFA Inhibitor ≥99.0% Phase 2
HY-51424 PLX-4720 Inhibitor 99.90% Phase 1
HY-12558 LY3009120 98.66% Phase 1
HY-15200 Agerafenib Inhibitor 99.78% Phase 1
HY-15610 GDC-0623 98.74% Phase 1
HY-18957 Lifirafenib Inhibitor 98.01% Phase 1
HY-159795 Claturafenib Inhibitor 99.95% Phase 1
HY-147405 Tinlorafenib Inhibitor 98.21% Phase 1
HY-15199 Agerafenib hydrochloride Inhibitor / Phase 1
HY-18957B Lifirafenib maleate Inhibitor / Phase 1
HY-19343 XL-281 Inhibitor / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991507 SCT200 Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (139)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50846 SCH772984 Inhibitor 99.83% Unkown
HY-10966 SB-590885 Inhibitor 99.77% Unkown
HY-101494 Temuterkib Inhibitor 99.94% Unkown
HY-158115 NST-628 Inhibitor 98.61% Unkown
HY-12661A AMG PERK 44 99.67% Unkown
HY-50864 GDC-0879 Inhibitor 99.49% Unkown
HY-147268 Exarafenib Inhibitor 99.68% Unkown
HY-153341 Tagarafdeg Degrader 99.41% Unkown
HY-11004 AZ 628 99.44% Unkown
HY-18832 AWL-II-38.3 Inhibitor 99.71% Unkown
HY-136420 SJF-0628 99.90% Unkown
HY-15767 TAK-632 Inhibitor 98.93% Unkown
HY-14177 Raf inhibitor 1 Inhibitor 98.03% Unkown
HY-137487 PROTAC BRAF-V600E degrader-1 Degrader 98.04% Unkown
HY-155736 MAPK-IN-2 Inhibitor 99.66% Unkown
HY-202699 SHOC2-RAS PPI-IN-1 Inhibitor 99.50% Unkown
HY-Y1322 Triphenyl phosphate 99.67% Unkown
HY-145120 Mosperafenib Inhibitor 98.29% Unkown
HY-17598 Rafoxanide 98.60% Unkown
HY-N9330 Broussoflavonol F Inhibitor 98.11% Unkown
HY-111758 PROTAC B-Raf degrader 1 Inhibitor 99.78% Unkown
HY-12846 CCT196969 Inhibitor 99.67% Unkown
HY-100510 RAF709 Inhibitor 99.92% Unkown
HY-18997 PLX7904 Inhibitor 98.72% Unkown
HY-10247 BRAF inhibitor Inhibitor 98.07% Unkown
HY-12787 L-779450 98.75% Unkown
HY-136567 TBAP-001 Inhibitor 98.97% Unkown
HY-77113 B-Raf IN 11 Inhibitor 99.46% Unkown
HY-107779 BI-882370 Inhibitor 98.55% Unkown
HY-12291 HG6-64-1 99.69% Unkown
HY-149464 ARN22089 Inhibitor 98.18% Unkown
HY-137346 DD-03-156 Degrader 99.90% Unkown
HY-181067 IK-595 Inhibitor 98.55% Unkown
HY-P10438 TAT-Braftide Inhibitor 99.52% Unkown
HY-148059 Uplarafenib Inhibitor 99.63% Unkown
HY-107415 PLX7922 Inhibitor 98.68% Unkown
HY-18227 B-Raf IN 1 Inhibitor 99.94% Unkown
HY-18507 AD57 Inhibitor 98.27% Unkown
HY-P10436 Braftide Inhibitor 99.51% Unkown
HY-10201S2 Sorafenib-13C,d3 98.35% Unkown
HY-117658 GSK-114 Inhibitor 99.52% Unkown
HY-153603 B-Raf IN 15 Inhibitor 98.0% Unkown
HY-142160 GNE-9815 Inhibitor 98.94% Unkown
HY-12847 CCT241161 99.77% Unkown
HY-144269 SHR902275 Inhibitor 99.80% Unkown
HY-149380 Vem-L-Cy5 Inhibitor 98.31% Unkown
HY-15605S Encorafenib-13C,d3 Inhibitor 98.14% Unkown
HY-RS01588 BRAF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117273 AZ304 Inhibitor 99.77% Unkown
HY-130617 Pomalidomide-amido-C1-Br / Unkown
HY-15198 KG5 Inhibitor 99.79% Unkown
HY-164474 DS03090629 Inhibitor / Unkown
HY-10966R SB-590885 (Standard) Inhibitor 99.55% Unkown
HY-10201S1 Sorafenib-d4 99.9% Unkown
HY-108887 Anticancer agent 124 Inhibitor / Unkown
HY-126298 RAF mutant-IN-1 Inhibitor / Unkown
HY-10201S4 Sorafenib-d3 tosylate Inhibitor / Unkown
HY-103086 INU-152 Inhibitor / Unkown
HY-115933 EGFR/BRAF-IN-1 Inhibitor / Unkown
HY-117707 EBI-907 Inhibitor / Unkown
HY-12057S Vemurafenib-d5 / Unkown
HY-12057S1 Vemurafenib-d7 / Unkown
HY-123799 SB-699393 Inhibitor / Unkown
HY-126180 BAY-866 Inhibitor / Unkown
HY-135216 Antiproliferative agent-54 Inhibitor / Unkown
HY-137488 PROTAC BRAF-V600E degrader-2 Inhibitor / Unkown
HY-13810 PF-04880594 Inhibitor / Unkown
HY-142820 B-Raf IN 5 Inhibitor / Unkown
HY-142830 B-Raf IN 6 Inhibitor / Unkown
HY-144271 RAF-IN-1 Inhibitor / Unkown
HY-146442 BRAF V600E/CRAF-IN-1 Inhibitor / Unkown
HY-146443 BRAF V600E/CRAF-IN-2 Inhibitor / Unkown
HY-146491 VEGFR-2/BRAF-IN-1 / Unkown
HY-146492 VEGFR-2/BRAF-IN-2 / Unkown
HY-147825 EGFR/BRAFV600E-IN-1 / Unkown
HY-147852 B-Raf IN 7 Inhibitor / Unkown
HY-147853 B-Raf IN 8 Inhibitor / Unkown
HY-147854 B-Raf IN 9 / Unkown
HY-149415 Multi-kinase-IN-5 Inhibitor / Unkown
HY-149517 EGFR/BRAFV600E-IN-2 / Unkown
HY-14979 ML786 Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-150250 B-Raf IN 13 Inhibitor / Unkown
HY-150639 Everafenib Inhibitor / Unkown
HY-153914 B-Raf IN 14 Inhibitor / Unkown
HY-155942 B-Raf IN 19 Inhibitor / Unkown
HY-156554 Raf inhibitor 3 Inhibitor / Unkown
HY-156590 B-Raf IN 16 Inhibitor / Unkown
HY-158027 B-Raf IN 17 Inhibitor / Unkown
HY-16063 ARQ-736 Inhibitor / Unkown
HY-162460 ERK1/2 inhibitor 10 Inhibitor / Unkown
HY-162873 MEK/RAF-IN-1 Inhibitor / Unkown
HY-164400 SIJ1777 / Unkown
HY-164428 AE 51310 Inhibitor / Unkown
HY-164492 LSN3074753 Inhibitor / Unkown
HY-168013 KRASG12C IN-14 Inhibitor / Unkown
HY-168125 JNK-IN-18 Inhibitor / Unkown
HY-168442 KRAS inhibitor-40 Inhibitor / Unkown
HY-168512 BRAFV600E-IN-1 Inhibitor / Unkown
HY-169869 pan-Raf/RTK inhibitor 1 Inhibitor / Unkown
HY-173164 EGFR/BRAFV600E-IN-4 / Unkown
HY-174274 ERK2-IN-6 Inhibitor / Unkown
HY-175435 CST905 Degrader / Unkown
HY-175726 BRAF ligand-Linker Conjugate 1 / Unkown
HY-175831 BRAFV600E-IN-2 Inhibitor / Unkown
HY-17598R Rafoxanide (Standard) / Unkown
HY-178995 BRAFV600E-IN-3 Inhibitor / Unkown
HY-179012 CDC20/HSP90-IN-1 / Unkown
HY-179098 Multi-target kinase-IN-8 / Unkown
HY-179505 OPN-9652 Inhibitor 98.84% Unkown
HY-179559 OPN-9643 Inhibitor / Unkown
HY-180154 EGFR/BRAFV600E-IN-6 / Unkown
HY-180161 B-Raf-IN-20 Inhibitor / Unkown
HY-180419 SF-3-030 / Unkown
HY-181061 COX/5-LO-IN-2 / Unkown
HY-181130 Anticancer agent 299 Inhibitor / Unkown
HY-181131 Anticancer agent 300 Inhibitor / Unkown
HY-181913 KRAS G12C-IN-76 Inhibitor / Unkown
HY-181978 GIT1-IN-1 / Unkown
HY-182763 EGFR/BRAFV600E-IN-7 / Unkown
HY-18318 Takeda-6D Inhibitor 99.41% Unkown
HY-183674 MEK-IN-10 / Unkown
HY-18507A AD57 hydrochloride Inhibitor / Unkown
HY-18652A Avutometinib potassium Inhibitor / Unkown
HY-E70649 BRAF V600E Recombinant Human Active Protein Kinase / Unkown
HY-N13841 2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose / Unkown
HY-P11706 MS1 peptide / Unkown
HY-RS01589 Braf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01590 Braf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120676 B-Raf IN 18 Inhibitor / Unkown
HY-14177A Raf inhibitor 1 dihydrochloride Inhibitor 99.29% Unkown
HY-164524 SBI-0640726 Inhibitor / Unkown
HY-164529 SJ-C1044 Inhibitor 98.63% Unkown
HY-164530 SKLB646 Inhibitor / Unkown
HY-177946 RAF-IN-4 Inhibitor / Unkown
HY-180329 CG 858-Neg / Unkown
HY-18817 AFG210 Inhibitor / Unkown
HY-41747 BRAF ligand-1 Ligand / Unkown
HY-51424S PLX-4720-d7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens BRAF NCBI NCBI:673