MAHS-3
MAHS-3 is a thymidylate synthase (TS) and dihydrofolate reductase (DHFR) inhibitor, with IC50 values of 5.279 μM and 52.60 μM against human targets, respectively. MAHS-3 exhibits broad-spectrum antiproliferative activity against cancer cells, induces cell cycle arrest, activates endogenous caspase-dependent apoptosis, reduces MMP levels, inhibits cell migration, increases intracellular NO levels, and promotes autophagy activity. MAHS-3 can be used in cancer-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C22H17ClN6O3
- 分子量:448.86
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
MMP-9 |
MMP-7 |
PARP-1 |
Caspase-7 |
Caspase-9 |
Bcl-2 |
Bax |
体外実験
MAHS-3 induces cell cycle arrest and upregulates the expression of p21 and p27; it activates endogenous caspase-dependent apoptosis and regulates the levels of Bax, Cas-7, Cas-9, Bcl-2 and PARP1[1].
MAHS-3 is a dual-target inhibitor that targets thymidylate synthase and dihydrofolate reductase, with IC50 values of 5.279 μM and 52.60 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 448.86
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分子式 C22H17ClN6O3
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SMILES
CC1=NN(C2=CC=CC=C2)C(N=C(CCl)N3CC4=NO[N+]([O-])=C4C5=CC=CC=C5)=C1C3=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MAHS-3 関連分類
HY-187513 関連分類
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Keywords
- MAHS-3
- MAHS3
- MAHS 3
- Dihydrofolate reductase (DHFR)
- Thymidylate Synthase
- MMP
- Caspase
- PARP
- Bcl-2 Family
- Apoptosis
- Autophagy
- intrinsic caspase-dependent apoptosis
- human dihydrofolate reductase
- non-small cell lung cancer
- matrix metalloproteinase-7
- thymidylate synthase
- G2/M-stage cell cycle arrest
- breast cancer cells
- leukemia
- leukemia cells
- colon cancer
- Inhibitor
- inhibitor
- inhibit