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Cat. No.: HY-187513

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MAHS-3

MAHS-3 is a thymidylate synthase (TS) and dihydrofolate reductase (DHFR) inhibitor, with IC₅₀ values of 5.279 μM and 52.60 μM against human targets, respectively. MAHS-3 exhibits broad-spectrum antiproliferative activity against cancer cells, induces cell cycle arrest, activates endogenous caspase-dependent apoptosis, reduces MMP levels, inhibits cell migration, increases intracellular NO levels, and promotes autophagy activity. MAHS-3 can be used in cancer-related research.

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화학식: C₂₂H₁₇ClN₆O₃
분자량:448.86

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

MAHS-3 Chemical Structure

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

MMP-9

MMP-7

PARP-1

Caspase-7

Caspase-9

Bcl-2

Bax

All MMP Isoforms :

All Caspase Isoforms :

All PARP Isoforms :

All Bcl-2 Family Isoforms :

In Vitro

MAHS-3 induces cell cycle arrest and upregulates the expression of p21 and p27; it activates endogenous caspase-dependent apoptosis and regulates the levels of Bax, Cas-7, Cas-9, Bcl-2 and PARP1^[1].
MAHS-3 is a dual-target inhibitor that targets thymidylate synthase and dihydrofolate reductase, with IC₅₀ values of 5.279 μM and 52.60 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 448.86
화학식 C₂₂H₁₇ClN₆O₃
SMILES

CC1=NN(C2=CC=CC=C2)C(N=C(CCl)N3CC4=NO[N+]([O-])=C4C5=CC=CC=C5)=C1C3=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Alotaibi FS, et al. Synthesis of N5-furoxan-functionalized pyrazolo[3,4-d]pyrimidinones as novel nonclassical DHFR/TS inhibitors with potential apoptotic and anti-migratory activity. Bioorganic chemistry. 2026 Jul 20;181:110269.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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상품명:
CAS No.:
Species:
Purity:
수량:

MAHS-3

All MMP Isoforms

All Caspase Isoforms

All PARP Isoforms

All Bcl-2 Family Isoforms