CH5164840
CH5164840 (16) shows high binding affinity for N-terminal Hsp90a (Kd = 0.52 nM) and strong anti-proliferative activity against human cancer cell lines (HCT116 IC50 = 0.15 μM, NCI-N87 IC50 = 0.066 μM). CH5164840 (16) is orally active (t1/2 = 2.64 h) with potent antitumor efficacy.
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- CAS No.: 1052645-73-4
- Formule: C19H23N5O2S
- Masse moléculaire:385.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.15 μM
Compound: 16, CH5164840
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Antiproliferative activity against human HCT116 cells
Antiproliferative activity against human HCT116 cells
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[PMID: 22192591] |
| NCI-N87 | IC50 |
0.066 μM
Compound: 16, CH5164840
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Antiproliferative activity against human NCI-N87 cells overexpressing Her-2
Antiproliferative activity against human NCI-N87 cells overexpressing Her-2
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[PMID: 22192591] |
Chemical Information
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CAS No. 1052645-73-4
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Masse moléculaire 385.48
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Formule C19H23N5O2S
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SMILES
O=C(NCCCNC1=O)CCSC2=CC(C3=CC1=C(C)C=C3C)=NC(N)=N2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CH5164840 Related Classifications
HY-15990 Related Classifications
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