CH5164840
CH5164840 (16) shows high binding affinity for N-terminal Hsp90a (Kd = 0.52 nM) and strong anti-proliferative activity against human cancer cell lines (HCT116 IC50 = 0.15 μM, NCI-N87 IC50 = 0.066 μM). CH5164840 (16) is orally active (t1/2 = 2.64 h) with potent antitumor efficacy.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1052645-73-4
- Fòrmula: C19H23N5O2S
- Peso molecular:385.48
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.15 μM
Compound: 16, CH5164840
|
Antiproliferative activity against human HCT116 cells
Antiproliferative activity against human HCT116 cells
|
[PMID: 22192591] |
| NCI-N87 | IC50 |
0.066 μM
Compound: 16, CH5164840
|
Antiproliferative activity against human NCI-N87 cells overexpressing Her-2
Antiproliferative activity against human NCI-N87 cells overexpressing Her-2
|
[PMID: 22192591] |
Chemical Information
-
No. CAS 1052645-73-4
-
Peso molecular 385.48
-
Fòrmula C19H23N5O2S
-
SMILES
O=C(NCCCNC1=O)CCSC2=CC(C3=CC1=C(C)C=C3C)=NC(N)=N2
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CH5164840 Related Classifications
HY-15990 Related Classifications
Powered by Bioz