CH5164840
CH5164840 (16) shows high binding affinity for N-terminal Hsp90a (Kd = 0.52 nM) and strong anti-proliferative activity against human cancer cell lines (HCT116 IC50 = 0.15 μM, NCI-N87 IC50 = 0.066 μM). CH5164840 (16) is orally active (t1/2 = 2.64 h) with potent antitumor efficacy.
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- CAS 番号: 1052645-73-4
- 分子式: C19H23N5O2S
- 分子量:385.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.15 μM
Compound: 16, CH5164840
|
Antiproliferative activity against human HCT116 cells
Antiproliferative activity against human HCT116 cells
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[PMID: 22192591] |
| NCI-N87 | IC50 |
0.066 μM
Compound: 16, CH5164840
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Antiproliferative activity against human NCI-N87 cells overexpressing Her-2
Antiproliferative activity against human NCI-N87 cells overexpressing Her-2
|
[PMID: 22192591] |
化学情報
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CAS 番号 1052645-73-4
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分子量 385.48
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分子式 C19H23N5O2S
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SMILES
O=C(NCCCNC1=O)CCSC2=CC(C3=CC1=C(C)C=C3C)=NC(N)=N2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CH5164840 関連分類
HY-15990 関連分類
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