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エトポシド

(別名: VP 16; Etoposide)
180 Cited Publications
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Based on 180 publication(s) in Google Scholar

Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy.

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  • 純度: 99.93%
  • CAS 番号: 33419-42-0
  • 分子式: C29H32O13
  • 分子量:588.56
  • 保管条件:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Etoposide Chemical Structure
    Etoposide 構造式
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
  • Experimental Validation Results for Etoposide
CAS 番号: 33419-42-0
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  • Etoposide Chemical Structure
    Etoposide Chemical Structure
    1/16
  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in:

    MedChemExpress Validation
    HeLa cells were cultured in 6 cm dishes to approximately 70% confluence and then treated with Etoposide (HY-13629) at concentration of 30 μM for 2 h and 4 h, respectively. Phospho-ATM (Ser1981) protein expression was subsequently analyzed by Western blot. The results demonstrated that Etoposide induced DNA damage in HeLa cells, indicated by phosphorylation of ATM (Ser1981). Primary antibodies used: Phospho-ATM (Ser1981) Antibody (HY-P87805) and GAPDH Antibody (HY-P80954A).

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Mar 7;134(10):e172716. [Abstract]

    Customer Validation
     The given cell lines were treated with 250 nM osimertinib (Osim), 1.25 μM Etoposide (VP-16), 125 nM Doxorubicin (DXR), 5 nM Paclitaxel, 10 μM Cisplatin, 25 μM Carboplatin, 25 nM Gemcitabine, 20 nM 5-Fluorouracil (5-FU), 25 μM Cyclophosphamide, 25 μM Capecitabine, or 10 nM Vincristine alone or in combination for 3 days. Cell numbers were then measured using the SRB assay.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 Nov 8;31(11):1820-1836.e10. [Abstract]

    Customer Validation
     Immunoblot and immunoprecipitation of lysates of HEK293T cells transfected with plasmids encoding Flag-UreC and exposed to etoposide (100 μg/ml) for 4 h.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Oncogene. 2023 Mar;42(13):967-979. [Abstract]

    Customer Validation
     Etoposide (VP16; 5 mg/kg; s.c.; every two days for 8 days) strongly suppresses tumor growth in mice.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: J Pharm Pharmacol. 2023 Apr 7;75(4):523-532. [Abstract]

    Customer Validation
     Irinotecan (CPT11; 20 μM; 48 h) or Etoposide (VP16; 20 μM; 48 h) induces MDA-MB-231 cells cycle arrest significantly.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]

    Customer Validation
     Cell sensitivity to Etoposide (ETO). Cancer cells are treated with etoposide at gradient concentrations for 48 hr.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]

    Customer Validation
     BCL6 mRNA expression in Etoposide (ETO)-resistant and -sensitive cells. Cells are treated with Etoposide at their respective 1/2 IC50s for 24 hr.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]

    Customer Validation
     Etoposide induced BCL6 protein expression in a time-dependent manner. ETO-resistant or -sensitive cells are treated with etoposide at their respective 1/4 IC50s for 2, 4, or 6 days.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]

    Customer Validation
     STAT1 protein and its phosphorylation levels by immunoblotting analysis. Etoposide (ETO)-resistant and -sensitive cells are treated with Etoposide at their respective 1/2 IC50s for indicated time points.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]

    Customer Validation
     Etoposide activated mTOR signaling components in Etoposide-resistant Capan-2 and PANC28 cells. Cells were treated with etoposide at their respective 1/2 IC50s for 6 or 12 hr. A long-term treatment with Etoposide activated mTOR signaling components in ETO-resistant cells. Capan-2 and PANC28 cells are treated with 10 μM Etoposide for 2 or 4 days.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Protein Cell. 2022 Jan;13(1):47-64. [Abstract]

    Customer Validation
     FISH of telomeres on metaphase spreads to detect chromosome end-to-end fusions in 6 kb-HeLa treated with VP-16. Control (Scr) or cGAS-depleted cells (gcGAS-1, gcGAS-2) are either harvested immediately following treatment (VP-16, 2 μM, 1 h) or released for 4 h (Release 4 h) during mitosis.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2021 Mar 12;12(3):265. [Abstract]

    Customer Validation
     Inhibition of PRDX1 increased the sensitivity of HCT116 cells to Etoposide-induced apoptosis: HCT116 cells infected with lentivirus expressing the indicated shRNAs were treated with 50 μM Etoposide for 0-6 h.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Hepatology. 2020 May;71(5):1660-1677. [Abstract]

    Customer Validation
     Exposure to Etoposide (Eto), another DNA-damaging agent, induces PDIA3P1 expression, suggesting that PDIA3P1 may be up-regulated by DNA-damaging agents.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2020 Sep 28;7(21):2001364. [Abstract]

    Customer Validation
     Lnc‐Ip53 attenuated the DNA damage- and oxidation stress-induced p53 acetylation at K382. Cells are incubated with 50 µM Etoposide (Eto) for 5 h.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2020 Sep 28;7(21):2001364. [Abstract]

    Customer Validation
     Lnc‐Ip53 attenuated the DNA damage‐ and oxidation stress‐triggered increase of CDKN1A and PUMA. Cells are incubated with 50 µM Etoposide (Eto) for 6 h.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jul 25;10(21):9477-9494. [Abstract]

    Customer Validation
     Fibroblasts and HT-1080 cells are treated with 20 µM Etoposide or DMSO (vehicle group) for 2, 4, 8, 16, 24 and 36 h.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jul 25;10(21):9477-9494. [Abstract]

    Customer Validation
     When cells are treated with 20 µM Etoposide or DMSO (vehicle group) for 4 h, western blots (WB) shows elevated expression of γH2AX, a marker of double-strand breaks (DSBs), in the Etoposide group.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jul 25;10(21):9477-9494. [Abstract]

    Customer Validation
     When cells are treated with 20 µM Etoposide, an obvious increased green focus of RAD51 is observed in the treated fibroblasts using immunofluorescence (IF) staining.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2020 Nov 6;12(11):e12525. [Abstract]

    Customer Validation
     Immunoblot of PARP1 cleavage of PeTa cells after 6 days of indicated treatment. Etoposide (10 μM; for 24 h) serves as positive control for apoptosis, and H3 serves as loading control.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Aging Cell. 2020 Jul;19(7):e13171. [Abstract]

    Customer Validation
     RPE p16‐mCherry cells were treated with DMSO, Etoposide (20 μM), H2O2 (200 μM), or serum starved for 24 hr.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Leuk Lymphoma. 2018 Jan;59(1):162-170. [Abstract]

    Customer Validation
     WT1 and caspase-3 protein levels are detected in two primary AML blasts treated with 100 μM Eto for 24 h.

  • 1/16

    Etoposide purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2017 Nov 1:408:43-54. [Abstract]

    Customer Validation
     Western blot analysis of p-p70S6k, p70S6k, p-AKT and AKT after 6 h of treatment with 20 μM RAD001. Levels of p-p70S6k and p-AKT are quantified by densitometric analysis and a corresponding histogram is constructed as relative to p70S6k or AKT and α-tubulin. The lower panel shows a representative Western blot.

  • Etoposide