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Cat. No.: HY-187514

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MAHS-4

MAHS-4 is an inhibitor of thymidylate synthase (TS) and dihydrofolate reductase (DHFR), with IC₅₀ values of 1.918 μM and 83.53 μM, respectively. MAHS-4 inhibits thymidylate biosynthesis, reduces tetrahydrofolate pool maintenance, and interferes with extracellular matrix remodeling. MAHS-4 induces G2/M phase cell cycle arrest, activates endogenous caspase-dependent apoptosis, decreases MMP protein levels, inhibits cell migration, increases intracellular NO levels, and promotes autophagy activity. MAHS-4 is applicable for cancer-related research.

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화학식: C₂₂H₁₆ClFN₆O₃
분자량:466.85

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

MAHS-4 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

Caspase-7

Caspase-9

MMP-7

MMP-9

PARP-1

Bcl-xL

Bax

All Bcl-2 Family Isoforms :

All Caspase Isoforms :

All PARP Isoforms :

All MMP Isoforms :

In Vitro

MAHS-3 induces cell cycle arrest and upregulates the expression of p21 and p27; it activates endogenous caspase-dependent apoptosis and regulates the levels of Bax, Cas-7, Cas-9, Bcl-2 and PARP1^[1].
MAHS-4 exhibits dose-dependent antiproliferative activity in various cancer cell lines, shows cytostatic activity in some cancer cell lines, and has significantly higher cytotoxicity against breast cancer cells than normal cells and non-tumorigenic cells; moreover, it has better cancer cell selectivity than MAHS-3 (HY-187513)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 466.85
화학식 C₂₂H₁₆ClFN₆O₃
SMILES

CC1=NN(C2=CC=C(F)C=C2)C(N=C(CCl)N3CC4=NO[N+]([O-])=C4C5=CC=CC=C5)=C1C3=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Alotaibi FS, et al. Synthesis of N5-furoxan-functionalized pyrazolo[3,4-d]pyrimidinones as novel nonclassical DHFR/TS inhibitors with potential apoptotic and anti-migratory activity. Bioorganic chemistry. 2026 Jul 20;181:110269.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

MAHS-4

All Bcl-2 Family Isoforms

All Caspase Isoforms

All PARP Isoforms

All MMP Isoforms