Quinidine-d3
Quinidine-d3 is the deuterated-labeled Quinidine (HY-B1751H). Quinidine is an orally effective antiarrhythmic agent. Quinidine blocks the fast inward sodium current in a use-dependent manner, blocks IKr in a reverse use-dependent manner, and blocks the ultra-rapid delayed rectifier potassium current with an EC50 of 6.2 μM, while also inhibiting CYP2D6 and P-gp. Quinidine induces PARP cleavage, Caspase-3 activation, and increases the proportion of sub-G1 phase apoptotic (Apoptotic) cells. Quinidine can be used in research on ischemia/reperfusion-induced cardiac injury, drug-resistant leukemia, convulsions, and uterine sarcoma.
For research use only. We do not sell to patients.
- CAS No.: 1267657-68-0
- Formula: C20H21D3N2O2
- Molecular Weight:327.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
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IKr |
P-gp |
CYP2D6 |
PARP |
Caspase 3 |
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1267657-68-0
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Unlabeled CAS 56-54-2
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Molecular Weight 327.44
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Formula C20H21D3N2O2
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SMILES
O[C@H]([C@]1([H])[N@@]2C[C@@H]([C@@H](CC2)C1)C=C)C3=CC=NC4=C3C=C(OC([2H])([2H])[2H])C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lee SY, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environmental toxicology. 2011 Aug;26(4):424-31. [Content Brief]
[2]. Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103(3):1807-13. [Content Brief]
[3]. Moody DE, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol. 1990 Sep-Oct;14(5):311-7. [Content Brief]
[4]. Jamali H, et al. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. Neurosci Lett. 2020 Jun 11;729:134988. [Content Brief]
[5]. Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Quinidine-d3 Related Classifications
HY-B1751S Related Classifications
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Keywords
- Quinidine-d3
- 1267657-68-0
- Isotope-Labeled Compounds
- Sodium Channel
- Parasite
- P-glycoprotein
- Apoptosis
- Caspase
- Potassium Channel
- Cytochrome P450
- PARP
- Na channels
- Na+ channels
- P-gp
- Pgp
- Multidrug resistance protein 1
- MDR1
- ATP-binding cassette sub-family B member 1
- ABCB1
- Cluster of differentiation 243
- CD243
- KcsA
- CYPs
- poly ADP ribose polymerase
- CYP2D6
- IKr
- antiarrhythmic
- atrial effective refractory period
- hKv1.5 channels
- ischemia/reperfusion
- multidrug resistance
- rapid inward sodium current
- ultrarapid delayed rectifier potassium current
- Inhibitor
- inhibitor
- inhibit